The aim of this paper is to recall the concept of total cost of ownership (TCO) of industrial asset to highlight its relevance in asset management. Nowadays, being able to evaluate the TCO of assets is more and more recognized by companies and researchers as a basis for taking informed decision making both for investments and managerial issues, nevertheless its importance within asset management strategy still remains generally undervalued. Based on a literature review, the paper defines a framework that categorizes the benefits and potential applications that a TCO model can have for different stakeholders. Together with that, industry related issues that influence its adoption are also considered. Based on that, empirical evidences are analyzed through a multiple case study to understand if those benefits are recognized in practice and which are the limitations, if any, for the practical adoption of a TCO model that should allow exploiting such benefits.