An association between belief in life after death and serum oxytocin in older people in rural Japan

Imamura, Yoshiomi; Mizoguchi, Yoshikazu; Nabeta, Hiromi; Haraguchi, Yoshinori; Matsushima, Jun; Kojima, Naoki; Kawashima, Toshiro; Yamada, Shigeto; Monji, Akira

doi:10.1002/gps.4453

Cited by 20 publications

(39 citation statements)

References 43 publications

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“…Baseline serum oxytocin levels were higher in women (0.123 ± 0.130 ng/ml) than in men (0.042 ± 0.052 ng/ml) as reported previously ( Imamura et al , 2017 ; Marazziti et al , 2019 ). The educational background was slightly higher in men (11.43 ± 2.53 years) than in women (9.41 ± 1.63 years).…”

Section: Resultssupporting

confidence: 84%

“…This study was a longitudinal study. The survey was conducted in Kurokawa-cho, Imari, Saga Prefecture, Japan, among people aged 65 years and older as reported previously ( Nabeta et al , 2014 ; Matsushima et al , 2015 ; Imamura et al , 2017 ). Kurokawa-cho is in northwestern Saga Prefecture and is a rural town somewhat removed from urban areas.…”

Section: Methodsmentioning

confidence: 99%

“…All samples were analysed in duplicate. The serum oxytocin was analysed using a commercially available peptide enzyme immunoassay (Peninsula Laboratories International, Belmont, CA, USA) with an extraction-free protocol as reported previously ( Afinogenova et al , 2016 ; Imamura et al , 2017 ; Schmelkin et al , 2017 ; Aita et al , 2019 ). A robust correlation has been reported between extracted serum oxytocin levels and unextracted serum oxytocin levels ( Lawson et al , 2013 ).…”

Section: Methodsmentioning

confidence: 99%

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Oxytocin and elderly MRI-based hippocampus and amygdala volume: a 7-year follow-up study

Orihashi

Mizoguchi

Imamura

et al. 2020

Brain Communications

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Oxytocin is deeply involved in human relations. In recent years, it is becoming clear that oxytocin is also involved in social cognition and social behavior. Oxytocin receptors are also thought to be present in the hippocampus and amygdala, and the relationship between oxytocin and the structure and function of the hippocampus and amygdala has been reported. However, few studies have investigated oxytocin and its relationship to hippocampus and amygdala volume in elderly people. The aim of this study is to investigate the association between serum oxytocin levels and hippocampus and amygdala volume in elderly people. The survey was conducted twice in Kurokawa-cho, Imari, Saga Prefecture, Japan, among people aged 65 and older. We collected data from 596 residents. Serum oxytocin level measurements, brain MRI, Mini-Mental State Examination and Clinical Dementia Rating were performed in Time 1 (2009–2011). Follow-up brain MRI, Mini-Mental State Examination and Clinical Dementia Rating were performed in Time 2 (2016–2017). The interval between Time 1 and Time 2 was about 7 years. Fifty-eight participants (14 men, mean age 72.36 ± 3.41 years, oxytocin 0.042 ± 0.052 ng/ml; 44 women, mean age 73.07 ± 4.38 years, oxytocin 0.123 ± 0.130 ng/ml) completed this study. We analyzed the correlation between serum oxytocin levels (Time 1) and brain volume (Time 1, Time 2, and Time 1–2 difference) using voxel-based morphometry implemented with Statistical Parametric Mapping. Analysis at the cluster level (family-wise error; P < 0.05) showed a positive correlation between serum oxytocin levels (Time 1) and brain volume of the region containing the left hippocampus and amygdala (Time 2). This result suggests that oxytocin in people aged 65 and older may be associated with aging-related changes in hippocampus and amygdala volume.

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Section: Resultssupporting

confidence: 84%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Oxytocin and elderly MRI-based hippocampus and amygdala volume: a 7-year follow-up study

Orihashi

Mizoguchi

Imamura

et al. 2020

Brain Communications

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“…Previously, in most cases, no sex differences were found [36-39], but there is also evidence of elevated levels in men [40]. Only one study [41] reported higher OT levels in older women than in men.…”

Section: Discussionmentioning

confidence: 99%

Sex-Related Differences in Plasma Oxytocin Levels in Humans

Marazziti¹,

Baroni²,

Mucci³

et al. 2019

CPEMH

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Background: Increasing evidence supports a key role of Oxytocin (OT) as a modulator of social relationships in mammals. Objective: The aim of the present study was to investigate possible sex-related differences in plasma OT levels in human beings. Methods: Forty-five healthy men and 45 women (mean age: 34.9 ± 6.2 years), were included in the study. Plasma preparation, peptide extraction and OT radioimmunoassay were carried out according to standardized methods. Results: The results showed that OT plasma levels (pg ̸ ml, mean ± SD) were significantly higher in women than in men (4.53 ± 1.18 vs 1.53 ± 1.19, p ˂ 0.001). Conclusions: The present finding demonstrates sex-related differences in plasma OT levels in humans. It is tempting to hypothesize that such differences might be related to behaviours, attitudes, as well as susceptibility to stress response, resilience and social emotions specific of women and men.

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“…All samples were analyzed in duplicate. Measurements were performed according to the manufacturer's instructions and based on our experiences as previously reported [50][51][52][53] .…”

Section: Assessment Of Cognitive Functionmentioning

confidence: 99%

Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study

Mizoguchi

Yao

Imamura

et al. 2020

Sci Rep

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The beneficial effects of brain-derived neurotrophic factor (BDNF)—a member of the neurotrophin family—on cognitive function or dementia are well established in both rodents and human beings. In contrast, little is known about the association of proBDNF—a precursor protein with opposing neuronal effects of BDNF—with cognitive function in non-demented older adults. We analyzed brain magnetic resonance imaging findings of 256 community-dwelling older adults (mean age of 68.4 years). Serum BDNF and proBDNF levels were measured by quantitative enzyme-linked immunosorbent assay. Logistic regression analysis revealed that older age, less physical activity, hippocampal atrophy, and lower BDNF levels were independently associated with memory impairment determined by the Rivermead Behavioral Memory Test. Path analysis based on structural equation modeling indicated that age, sport activity, hippocampal atrophy and BDNF but not proBDNF were individually associated with Rivermead Behavioral Memory Test scores. These findings suggest that impaired BDNF function, in addition to physical inactivity and hippocampal atrophy, is associated with age-related memory impairment. Therefore, BDNF may be a potential target for dementia prevention.

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An association between belief in life after death and serum oxytocin in older people in rural Japan

Cited by 20 publications

References 43 publications

Oxytocin and elderly MRI-based hippocampus and amygdala volume: a 7-year follow-up study

Oxytocin and elderly MRI-based hippocampus and amygdala volume: a 7-year follow-up study

Sex-Related Differences in Plasma Oxytocin Levels in Humans

Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study

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