An association between time-varying serum albumin level and the mortality rate in maintenance haemodialysis patients: a five-year clinical cohort study

Chen, Jin‐Bor; Cheng, Ben-Chung; Yang, Chih‐Jen; Moi, Sin-Hua

doi:10.1186/s12882-016-0332-5

Cited by 24 publications

(31 citation statements)

References 12 publications

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“…Initially, the exercise and control groups did not show a significant difference with regard to qualitative and quantitative variables as well as muscle capacity and albumin levels. Almost half of the patients in this study had albumin levels lower than 4 g/dL and for each 0.1 g/dL of albumin lower than 4 g/dL, the mortality rate significantly increased (18,19). As for their muscle capacity, most of the patient's grip strength was lower than normal standards.…”

Section: Discussionmentioning

confidence: 70%

The Effect of Intradialytic Isometric Resistance Training on Muscle capacity and Serum Albumin Levels in Hemodialysis Patients

2018

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Background: Muscle wasting and protein malnutrition is a common problem in hemodialysis patients and has different complications such as a reduced quality of life, longer hospital stays, and higher mortality rates. The aim of this study was to evaluate the effect of 8 weeks of intradialytic isometric training on muscle capacity and serum albumin levels in hemodialysis (HD) patients. Methods: In a clinical trial, 34 patients were randomly allocated into 2 groups: exercise group (EX) (n = 17) and control group (n = 17). The training program was conducted twice a week for 2 months (24 sessions). Forearm endurance, leg raise endurance, and grip strength were measured for muscle capacity aspect and serum albumin levels, which were evaluated before and post-intervention. Results: There was no significant difference between the groups in terms of demographic variables (P and gt; 0.05). After the intervention, the muscle capacity variable presented a significant difference between the exercise group and the control group (P and lt; 0.001). As for the albumin levels, there was no significant difference between the 2 groups. Conclusions: The results showed that exercise during hemodialysis could increase muscle capacity and could be helpful for maintaining the albumin levels in hemodialysis patients.

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Section: Discussionmentioning

confidence: 70%

The Effect of Intradialytic Isometric Resistance Training on Muscle capacity and Serum Albumin Levels in Hemodialysis Patients

2018

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“…In addition, the overlapping clinical factors in the interaction models, DM, age, and albumin levels, and CT ratio, were associated with mortality in CKD, which has been reported by several studies. 26 – 30 …”

Section: Discussionmentioning

confidence: 99%

Higher-order clinical risk factor interaction analysis for overall mortality in maintenance hemodialysis patients

Yang

Moi

Chuang

et al. 2020

Therapeutic Advances in Chronic Disease

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Background and Aims: In Taiwan, approximately 90% of patients with end-stage renal disease receive maintenance hemodialysis. Although studies have reported the survival predictability of multiclinical factors, the higher-order interactions among these factors have rarely been discussed. Conventional statistical approaches such as regression analysis are inadequate for detecting higher-order interactions. Therefore, this study integrated receiver operating characteristic, logistic regression, and balancing functions for adjusting the ratio in risk classes and classification errors for imbalanced cases and controls using multifactor-dimensionality reduction (MDR-ER) analyses to examine the impact of interaction effects between multiclinical factors on overall mortality in patients on maintenance hemodialysis. Meterials and Methods: In total, 781 patients who received outpatient hemodialysis dialysis three times per week before 1 January 2009 were included; their baseline clinical factor and mortality outcome data were retrospectively collected using an approved data protocol (201800595B0). Results: Consistent with conventional statistical approaches, the higher-order interaction model could indicate the impact of potential risk combination unique to patients on maintenance hemodialysis on the survival outcome, as described previously. Moreover, the MDR-based higher-order interaction model facilitated higher-order interaction effect detection among multiclinical factors and could determine more detailed mortality risk characteristics combinations. Conclusion: Therefore, higher-order clinical risk interaction analysis is a reasonable strategy for detecting non-traditional risk factor interaction effects on survival outcome unique to patients on maintenance hemodialysis and thus clinically achieving whole-scale patient care.

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“…In large observational studies, strongest association with reduced mortality was seen in groups having serum albumin ≥ 40g/L [7,11]. Lower serum albumin levels have also been associated with peripheral vascular disease, chronic obstructive pulmonary disease, cancer and patients using temporary catheters [12].…”

Section: Discussionmentioning

confidence: 99%

“…Despite improvements in dialysis technology, the mortality rates remain high in the dialysis population compared to the age-matched general population [3]. Large observational studies have identified short HSD, high ultrafiltration rates (UFR) and high intradialytic weight gain (IDWG) as important independent markers of mortality and adverse cardiovascular outcomes [4-7].…”

Section: Introductionmentioning

confidence: 99%

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Hemodialysis Session Duration, Ultrafiltration Rate, Interdialytic Weight Gain and their Association with Albumin in Patients on Intermittent Hemodialysis in a Regional Dialysis Unit: A Cross-sectional Study

Ahmed

Abdalla

Satti

et al. 2018

Cureus

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Aim Several studies suggest that a low pre-dialysis serum albumin level (<40g/L) is associated with increased mortality in dialysis patients. The objective of this study was to assess if hemodialysis session duration (HSD), ultrafiltration rate (UFR) and interdialytic weight gain percentage (IDWG%) are associated with pre-dialysis serum albumin levels (markers of all-cause mortality), thus influencing mortality. Method This is a cross-sectional analytical study in which data were collected from a regional cohort of 59 prevalent chronic hemodialysis patients using a national electronic database (eMED). Continuous data were analyzed using a regression model to assess for an association between HSD, IDWG% and UFR with albumin levels. Results Fifty-six patients were included in the study. Multiple linear regression models demonstrated a cross-sectional association between longer HSD and higher serum albumin levels and a statistically significant positive correlation ( r = 0.353; p < 0.05). No significant association of UFR ( p = 0.169) and IDWG% ( p = 0.549) with albumin was observed. Mean albumin was 38.07 ± 3.96 g/L in the HSD <240 min group compared to 40.50 ± 2.83g/L in the HSD ≥240 min group which was statistically significant ( p < 0.05). Conclusion Longer HSD has a cross-sectional association with higher pre-dialysis serum albumin with patients having HSD ≥240 min demonstrating the highest levels of serum albumin. Our study suggests longer HSD may improve mortality in the dialysis population.

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An association between time-varying serum albumin level and the mortality rate in maintenance haemodialysis patients: a five-year clinical cohort study

Cited by 24 publications

References 12 publications

The Effect of Intradialytic Isometric Resistance Training on Muscle capacity and Serum Albumin Levels in Hemodialysis Patients

The Effect of Intradialytic Isometric Resistance Training on Muscle capacity and Serum Albumin Levels in Hemodialysis Patients

Higher-order clinical risk factor interaction analysis for overall mortality in maintenance hemodialysis patients

Hemodialysis Session Duration, Ultrafiltration Rate, Interdialytic Weight Gain and their Association with Albumin in Patients on Intermittent Hemodialysis in a Regional Dialysis Unit: A Cross-sectional Study

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