An association between transient hypokalemia and severe acute oxaliplatin-related toxicity predominantly in women

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo

“…In contrast, oxaliplatin was widely ineffective at the given concentration, which was probably based on the occurrence of very strong adverse effects, which also made the early sacrifice due to the bad physical condition of the treated mice necessary. Enhanced sensitivity of females to oxaliplatin has been also reported for patients, 33–35 indicating gender differences for this drug due to yet unexplored reasons.…”

Oxaliplatin Induced Digital Ischemia and Necrosis

“…Despite its cytotoxic potency on DNA, this molecule has favorable toxicity profile. Most common side effects of this drug include neutropenia, fatigue, skin rash, ototoxicity, hypokalemia, and chemotherapy-induced peripheral neuropathy [ 7 ]. Peripheral neuropathy is a characteristic toxicity related to oxaliplatin usage that occurs in 15%–60% of patients.…”

Glucose conjugated platinum(II) complex: Antitumor superiority to oxaliplatin, combination effect and mechanism of action

“…Oxaliplatin, or the oxaliplatin-based FOLFOX (Oxaliplatin/FA/5-FU combination) combination therapy, remains the mainstay of first-line treatment for colon cancer. However, the drug resistance and severe side effects of oxaliplatin-based chemotherapy are still challenging propositions that encourage and attract scientists to explore new strategies and discover more promising, new generation of platinum antitumor agents [2,3].…”