An Association Between Trichomonas vaginalis and High-Risk Human Papillomavirus in Rural Tanzanian Women Undergoing Cervical Cancer Screening

Lazenby, Gweneth B.; Taylor, Peyton T.; Badman, Barbara S.; Mchaki, Emil; Korte, Jeffrey E.; Soper, David E.; Pierce, Jennifer Young

doi:10.1016/j.clinthera.2013.11.009

Cited by 82 publications

(84 citation statements)

References 26 publications

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“…Lazenby et al [27] discovered more than sixfold higher risk of women with TV being infected with HPV type 16 infection. We saw an association of TV with ASCUS and LSIL which was similar to the findings of a Belgian study where such associations were seen among women with high-risk HPV infection [28].…”

Section: Discussionmentioning

confidence: 99%

Reproductive Tract infections and Premalignant Lesions of Cervix: Evidence from Women Presenting at the Cancer Detection Centre of the Indian Cancer Society, Delhi, 2000–2012

Dey

Pahwa

Mishra

et al. 2016

J Obstet Gynecol India

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Objectives Burden of cervical cancer (CC) is highest for women in low-and middle-income countries (LMICs).Human papillomavirus (HPV) is implicated as the necessary cause of CC although a number of other factors aid the long process of CC development. One among them is the presence of reproductive tract infections (RTIs). This study investigated the associations between RTIs and CC from India. Methods This study utilized secondary data from the Cancer Detection Centre of the ICS, Delhi. Data were accessed from MS access database and were analyzed using MS Excel and SPSS 16.0. Multivariate analysis using unconditional logistic regression produced odds ratios (ORs) and 95 % confidence intervals (CIs). Results This study used data from 11,427 women over a period of 2000-2012. Women with RTIs had Candida, Trichomonas vaginalis (TV) or coccoid infections with all having similar prevalence (*4-5 %). 9.4 % of women had premalignant lesions of cervix; ASCUS was most common (7.9 %) followed by LSIL (1.3 %). TV was significantly associated with ASCUS, LSIL and all premalignant lesions

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Section: Discussionmentioning

confidence: 99%

Reproductive Tract infections and Premalignant Lesions of Cervix: Evidence from Women Presenting at the Cancer Detection Centre of the Indian Cancer Society, Delhi, 2000–2012

Dey

Pahwa

Mishra

et al. 2016

J Obstet Gynecol India

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“…High-risk HPVs, including HPV-16 and HPV-18, are able to induce cervical cancers and also contribute to a high proportion of other anogenital and oropharyngeal cancers (8), whereas low-risk HPVs, such as HPV-6 and HPV-11, induce anogenital warts and recurrent respiratory papillomatosis (9). Previous studies have focused on the association between HPV infection and gynecologic disease, and have demonstrated that numerous women with vaginitis also have HPV infection (10,11). For example, the study by Weihua (12) used fluorescent quantitative polymerase chain reaction (qPCR) to demonstrate that HPV-11 levels were high in patients with vaginitis, and a meta-analysis by Banura et al (13) showed that women with HPV infections were at a greater risk of developing bacterial vaginitis.…”

Section: Introductionmentioning

confidence: 99%

Effects of siRNA-mediated suppression of HPV-11 L1 expression on the proliferation and apoptosis of vaginal epithelial cells

Zeng

Yang

Wang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the effects of human papillomavirus (HPV) infection on the gynecological disease of vaginitis and to demonstrate how the small interfering RNA (siRNA) method may be used for HPV prevention in the clinic. Human vaginal epithelial cells were transfected with HPV-11 L1 expression vector and siRNA-HPV-11 L1 vectors and a control group was transfected with scrambled siRNA. Cell proliferation in each group was analyzed using the MTT assay and the expression of apoptosis-associated proteins was measured by western blot analysis. Compared with the control group, HPV-11 L1 mRNA and protein levels were significantly increased following transfection with the HPV-11 L1 expression vector in cells (P<0.05), but this result was significantly reversed by silencing of HPV-11 L1 (P<0.05). In addition, cell proliferation in the HPV-11 group was lower than that in the control group; however, cell proliferation was significantly increased in cells transfected with silenced L1 compared with that in the control group (P<0.05). Furthermore, silencing of HPV-11 L1 significantly decreased caspase-3 and caspase-9 expressions in cells, whereas the expression was increased in the HPV-11 L1 group (P<0.05). The present study suggested that siRNA-mediated silencing of HPV-11 L1 may have potential therapeutic applications for treating gynecological diseases associated with HPV-11 infection.

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“…Moreover, infection with T. vaginalis in pregnant women has been associated with premature rupture of membranes, premature labor, abortion, low birth weight, and increased infant mortality (Cotch et al 1997;Cherpes et al 2006). Another serious aspect of trichomoniasis is its relationship with an increased risk for human immunodeficiency virus (HIV) and human papillomavirus (HPV) infections (Minkoff et al 1984;McClelland et al 2007;Lazenby et al 2014;Van Der Pol et al 2008). It can also cause prostatitis, balanoposthitis, epididymitis, reduced sperm function, infertility, and higher risk of prostate cancer in men (Harp and Chowdhury 2011;Petrin et al 1998;Cudmore et al 2004;Twu et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Trichomoniasis in older individuals: a preliminary report from Iran

et al. 2016

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Infection with Trichomonas vaginalis is one of the most common sexually transmitted diseases (STDs) in humans. The prevalence of infection in Iran has been reported 0.009-8 % depending on deferent socio-cultural conditions. This study aimed to determine the frequency of T. vaginalis according to age in patients referred to clinics, hospitals and medical diagnostic laboratories in Karaj city, Iran. For this purpose, fifty positive samples were collected from July 2012 to June 2014 from clinics, medical diagnostic laboratories and hospitals, then transferred to laboratory of parasitology and cultured in TYM medium. The results showed that all isolates were successfully cultured. Among 50 positive specimens, 43 cases were female and 7 cases male. The most positive cases (34 %) belonged to the ages over 50 year's group. The lowest positive cases (2 %) belonged to the ages of less than 20 years group. In Conclusion, unlike other STDs, which have a higher prevalence among adolescents and young adults, the rates of trichomoniasis are more evenly distributed among sexually active women of all age groups. However, frequency of this infection in women aged over 50 years (age of menopause) is notable and complementary studies are needed.

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An Association Between Trichomonas vaginalis and High-Risk Human Papillomavirus in Rural Tanzanian Women Undergoing Cervical Cancer Screening

Cited by 82 publications

References 26 publications

Reproductive Tract infections and Premalignant Lesions of Cervix: Evidence from Women Presenting at the Cancer Detection Centre of the Indian Cancer Society, Delhi, 2000–2012

Reproductive Tract infections and Premalignant Lesions of Cervix: Evidence from Women Presenting at the Cancer Detection Centre of the Indian Cancer Society, Delhi, 2000–2012

Effects of siRNA-mediated suppression of HPV-11 L1 expression on the proliferation and apoptosis of vaginal epithelial cells

Trichomoniasis in older individuals: a preliminary report from Iran

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