2003
DOI: 10.2337/diabetes.52.5.1137
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An Association of Autoantibody Status and Serum Cytokine Levels in Type 1 Diabetes

Abstract: At onset of type 1 diabetes, the islet autoantibody status of patients has been reported to predict progression of the disease. We therefore tested the hypothesis that the systemic immunoregulatory balance, as defined by levels of circulating cytokines and chemokines, is associated with islet autoantibody status. In 50 patients with recent-onset type 1 diabetes, antibodies to GAD and insulinoma-associated antigen 2 (IA-2) were analyzed by radioimmunoassay; cytoplasmic islet cell antibodies were determined by i… Show more

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Cited by 74 publications
(59 citation statements)
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“…In vivo, the observed decrease in L-cell numbers could be due to direct toxic action of streptozotocin plus accompanying glucose toxicity as there was no evidence of intestinal lymphocyte infiltration. However, our in vitro observations indicate susceptibility of L-cells to cytokines and thus elevated concentrations of pro-inflammatory cytokines and glucose observed in circulation in type 1 diabetes (Lechleitner et al 2000, Hanifi-Moghaddam et al 2003, Chatzigeorgiou et al 2010 could affect L-cell function and survival. Elevated level of TNFa after a single high-dose streptozotocin treatment has been reported recently (Ho et al 2014), but further investigations are required to assess cytokine levels after multiple low-dose streptozotocin treatment.…”
Section: Discussionmentioning
confidence: 72%
“…In vivo, the observed decrease in L-cell numbers could be due to direct toxic action of streptozotocin plus accompanying glucose toxicity as there was no evidence of intestinal lymphocyte infiltration. However, our in vitro observations indicate susceptibility of L-cells to cytokines and thus elevated concentrations of pro-inflammatory cytokines and glucose observed in circulation in type 1 diabetes (Lechleitner et al 2000, Hanifi-Moghaddam et al 2003, Chatzigeorgiou et al 2010 could affect L-cell function and survival. Elevated level of TNFa after a single high-dose streptozotocin treatment has been reported recently (Ho et al 2014), but further investigations are required to assess cytokine levels after multiple low-dose streptozotocin treatment.…”
Section: Discussionmentioning
confidence: 72%
“…Another possibility is the induction of antibody reactivity against GAD and the development of full-blown diabetes, mediated by IL-18 and other proinflammatory cytokines. In particular, IL-18 is presumed to play a pathogenetic role in T1DM, specifically because this cytokine appears to be involved in acceleration of the development of overt disease [152,[158][159][160] . IL-18 can induce both Th1 and Th2 responses, depending on the surrounding cytokines [161] , and this cytokine plays a pathogenic role in several diseases [161] , including acute hepatic injury [162] .…”
Section: Direct Effects Of Hcv and Irmentioning
confidence: 99%
“…Experimental data from T1D patients and animal models also suggests a role for MIF in T1D development [9][10][11][12]. We have performed the most comprehensive screening of the MIF gene and its surrounding genomic region to date to identify variants and obtain allele frequencies for our population.…”
Section: Discussionmentioning
confidence: 99%