An association of serum vitamin D concentrations &lt; 40 nmol/L with acute respiratory tract infection in young Finnish men

Laaksi, Ilkka; Ruohola, Juha-Petri; Tuohimaa, Pentti; Auvinen, Anssi; Haataja, Riina; Pihlajamäki, Harri; Ylikomi, Timo

doi:10.1093/ajcn/86.3.714

Cited by 367 publications

(282 citation statements)

References 17 publications

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“…14 Cathelicidin transcription is particularly dependent on sufficient circulating levels of 25(OH)D. 14,33 The findings of the present study are consistent with these biologic principles and other epidemiologic reports linking low serum 25(OH)D levels to increased risks of infection in the nondialysis population. 34,35 The present study makes an important contribution to the literature by demonstrating this association in the chronic dialysis population and provides another plausible mechanism for the well known impaired immunity in these patients. The exact mechanisms by which 25(OH)D may protect against CVD have not been fully delineated.…”

Section: Discussionsupporting

confidence: 62%

Low Vitamin D and High Fibroblast Growth Factor 23 Serum Levels Associate with Infectious and Cardiac Deaths in the HEMO Study

Chonchol

Greene

Zhang

et al. 2016

Journal of the American Society of Nephrology

136

125

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In contrast, the highest FGF23 quartile was associated with a higher risk of infectious events (HR, 1.57 versus the lowest quartile; 95% CI, 1.13-2.18), cardiac events (HR, 1.49; 95% CI, 1.06-2.08), and allcause mortality (HR, 1.50; 95% CI, 1.07-2.12) in fixed-covariate Cox models. The addition of inflammation markers into the statistical models did not attenuate these associations. Thus, disordered mineral metabolism may affect outcomes in chronic hemodialysis patients. Cardiac events are the major cause of death in hemodialysis patients, accounting for approximately 40-50% of deaths. 1,2 Similarly, infections remain a very common cause of morbidity and mortality. [3][4][5] Several nontraditional risk factors may contribute to these two important clinical outcomes in this high-risk population, such as CKDassociated mineral and bone disorder 6 which includes a wide range of abnormalities in vitamin D metabolism 7-9 and phosphate homeostasis. 10,11 Lower serum levels of both 25-hydrovitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH) 2 D) have been associated with increased mortality within 90 days of initiating hemodialysis. 8 However, no studies have evaluated annual repeated measures of vitamin D analytes in

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Section: Discussionsupporting

confidence: 62%

Low Vitamin D and High Fibroblast Growth Factor 23 Serum Levels Associate with Infectious and Cardiac Deaths in the HEMO Study

Chonchol

Greene

Zhang

et al. 2016

Journal of the American Society of Nephrology

136

125

View full text Add to dashboard Cite

show abstract

“…The principal physiological function of 1,25(OH) 2 D 3 is enhancing the absorption of calcium and phosphate from the intestinal tract, therefore positively regulating bone formation [9][10][11] . To date, several lines of epidemiological and experimental findings have supported the links of vitamin D with various conditions or diseases beyond bone health [3] , including muscle function [12,13] , autoimmune diseases [14] , cancer [15,16] , cardiovascular diseases (CVD) [17][18][19] , hypertension [20,21] , diabetes [22] , inflammatory diseases [23] , and all-cause mortality [24] , etc.…”

Section: General Roles Of Vitamin D In Physiological Conditions and Dmentioning

confidence: 99%

Role of vitamin D in immune responses and autoimmune diseases, with emphasis on its role in multiple sclerosis

Zhang

2010

Neurosci. Bull.

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“…Previous studies have reported associations between low serum 25(OH)D concentration and increased occurrence of RTI (2,18,19) . However, other studies performed in selected populations have not found a significant association (20,21) .…”

mentioning

confidence: 95%

Association between serum 25-hydroxyvitamin D concentration and symptoms of respiratory tract infection in a Norwegian population: the Tromsø Study

Robertsen

Grimnes

Melbye

2013

Public Health Nutr.

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Objective: Previous studies have suggested anti-infection effects of vitamin D, although the associations reported between vitamin D (serum 25-hydroxyvitamin D (25(OH)D) concentration) and respiratory tract infection (RTI) are conflicting. The main aim of the present study was to explore this association in a Norwegian population. Design: We examined the association between serum 25(OH)D and recent RTI symptoms in 6350 middle-aged and elderly participants in the Tromsø Study 6. The main outcome measurement was self-reported RTI symptoms in the previous week. Setting: Tromsø, Norway, 698N. Subjects: Six thousand three hundred and fifty middle-aged and elderly residents of Tromsø. Results: Of the 6350 included, 791 (12?5 %) reported RTI symptoms in the previous week. We classified serum 25(OH)D concentrations into quartiles and adjusted the data for current smoking habit and month of attendance. The prevalence of RTI symptoms did not increase with decreasing serum 25(OH)D level, was highest in quartile 3 (15?0 %) followed by quartile 4 (12?4 %), and was lowest in quartiles 1 and 2 (11?1 % and 11?4 %). There was no trend for increasing duration of illness with decreasing serum 25(OH)D. The prevalence of RTI symptoms was not significantly associated with the intake of fish, n-3 capsules or vitamin and/or mineral supplements, or sun exposure. Only use of cod-liver oil or fish oil capsules daily or sometimes was significantly associated with fewer RTI symptoms during the preceding 7 d (P 5 0?04). Conclusions: Low serum 25(OH)D was not associated with increased prevalence of recent RTI symptoms. Our findings do not support the idea that vitamin D supplementation can reduce the incidence of RTI in Norway.

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An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men

Abstract: Clinical trials of vitamin D supplementation are needed to investigate whether it enhances immunity to microbial infections.

Cited by 367 publications

References 17 publications

Low Vitamin D and High Fibroblast Growth Factor 23 Serum Levels Associate with Infectious and Cardiac Deaths in the HEMO Study

Low Vitamin D and High Fibroblast Growth Factor 23 Serum Levels Associate with Infectious and Cardiac Deaths in the HEMO Study

Role of vitamin D in immune responses and autoimmune diseases, with emphasis on its role in multiple sclerosis

Association between serum 25-hydroxyvitamin D concentration and symptoms of respiratory tract infection in a Norwegian population: the Tromsø Study

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