An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese

Molecular Docking Analysis of Four Drugs (Phenytoin, Amoxicillin, Aceclofenac and Ciprofloxacin) and Their Association With Four Human Leukocyte Antigen (HLA) Alleles

“…The most common drugs that cause SJS and TEN include abacavir, aceclofenac, albendazole, allopurinol, aminopenicillin, amlodipine, amoxycillin, barbiturates, carbamazepine, cephalosporin, chloroquine, ciprofloxacin, cotrimoxazole, dapsone, diclofenac, doxycycline, ethambutol, erythromycin, felbamate, fluconazole, fluoroquinolone, homeopathic medicines, ibuprofen, isoniazid, ketoprofen, lamotrigine, levofloxacin, naproxen, nevirapine, oxicam, paracetamol, phenytoin, piroxicam, promethazine, rifampicin, rofecoxib, sulfasalazine, sulfadiazine, sulfadoxine, sulindac, thiacetazone, valdecoxib and vancomycin [1,2,3,[8][9][10][11]. Based on the literature survey, four drugs were selected: (a) an anti-epileptic/anti-convulsant drug (phenytoin, PHT), (b) antibiotic drugs (amoxicillin (AMX) and ciprofloxacin (CIP)) and (c) a nonsteroidal anti-inflammatory drug (aceclofenac (ACE)).…”