An Assumed Vertical Transmission of SARS-CoV-2 During Pregnancy: A Case Report and Review of Literature

Mohakud, Nirmal Kumar; Yerru, Hari; Rajguru, Monalisha; Ss, Naik

doi:10.7759/cureus.10659

Cited by 6 publications

(8 citation statements)

References 12 publications

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“…To correctly diagnose COVID-19 in a child, apart from obtaining a nasopharyngeal smear, chest imaging and rectal swab can be performed [75]. In the case report, Mohakund et al [76] confirmed COVID-19 infection in a newborn based on a sample collected at 12 h of life. The newborn required resuscitation and mechanical ventilation, but no changes were found on the chest X-ray.…”

Section: Intrauterine and Transplacentar Transmissionmentioning

confidence: 99%

“…The newborn required resuscitation and mechanical ventilation, but no changes were found on the chest X-ray. Before delivery, COVID-19 infection was also confirmed in the mother of the baby [76]. Moreover, in the case of intrauterine viral transmission from mother to child, attention should be paid to the level of IgM for SARS-CoV-2 and the cytokine IL-6 in the serum of newborns [77].…”

Section: Intrauterine and Transplacentar Transmissionmentioning

confidence: 99%

See 1 more Smart Citation

Pregnancy and Childbirth in the COVID-19 Era—The Course of Disease and Maternal–Fetal Transmission

Mazur-Biały

Kołomańska-Bogucka

Tim

et al. 2020

JCM

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From the beginning of the Coronavirus Disease 2019 (COVID-19) pandemic, special attention has been paid to pregnant women and to monitoring comorbidities, such as gestational diabetes and hypertension, which could increase their risk of disease and death. The purpose of this review is to synthesize the available knowledge on the course of COVID-19 in pregnant women as well as the risk of maternal–fetal transmission. The study indicated that the course of COVID-19 is worse in pregnant women who are more often admitted to intensive care units or who require mechanical ventilation than nonpregnant women with COVID-19. Some symptoms, such as dyspnea and cough, were similar to those observed in nonpregnant women, but fever, headache, muscle aches, chills, and diarrhea were less frequent. A study revealed that premature delivery and cesarean section were more common in pregnant women diagnosed with COVID-19. In addition, recent studies confirm the possibility of intrauterine maternal–fetal transmission by positive genetic tests and the presence of IgM in newborns just after delivery; at the moment, the probability of transmission through mother’s milk is inconclusive. Considering all the above, a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is an important factor that threatens the health and life of both the mother and the fetus, but further studies are still needed.

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Section: Intrauterine and Transplacentar Transmissionmentioning

confidence: 99%

Section: Intrauterine and Transplacentar Transmissionmentioning

confidence: 99%

Pregnancy and Childbirth in the COVID-19 Era—The Course of Disease and Maternal–Fetal Transmission

Mazur-Biały

Kołomańska-Bogucka

Tim

et al. 2020

JCM

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“…Although the virus has been found to have multiple routes of transmission, limited data exist on whether the vertical transmission of SARS-CoV-2 can occur from asymptomatic infected mothers to their newborns during pregnancy. Recent systematic reviews and case reports have not yet definitively verified the rate of vertical transmission during pregnancy [ 1 - 4 ]. We report a full-term newborn with positive SARS-CoV-2 reverse transcriptase-polymerase chain reaction (RT-PCR) 24 hours after delivery by an asymptomatic COVID-19 positive pregnant mother.…”

Section: Introductionmentioning

confidence: 99%

Possible Vertical Transmission From an Unsuspected SARS-CoV-2-Infected Mother to Her Newborn

Naseh¹,

Ashrafzadeh²

2021

Cureus

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Although the Coronavirus Disease 2019 (COVID-19) has been found to have multiple routes of transmission, limited data exist on whether the vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur from asymptomatic infected mothers to their newborns during pregnancy. We report a full-term newborn girl who was found to be positive for COVID-19 at 24 hours of life and subsequently symptomatic with fever, tachycardia, tachypnea, elevated lactate dehydrogenase, and elevated total bilirubin. The newborn was delivered by a mother who was not suspected of having COVID-19 before giving birth, but who developed fever and dyspnea five hours after delivery and was found to be positive for COVID-19. Upon further history collection, the mother reported recent mild nasal congestion in the days prior to delivery. This case highlights that the vertical transmission of COVID-19 to a newborn may occur late during the third trimester from a mother who was not suspected of having the infection. All pregnant women may need to be screened for COVID-19 symptoms, including non-specific symptoms, prior to admission for labor and delivery floors in order to perform diagnostic tests and recommended safety precautions to keep newborns and hospital personnel safe.

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“…Un total de 22 madres embarazadas fueron incluidas en los estudios de caso clínico, de las cuales, 21 dieron resultado positivo a la prueba PCR nasofaríngea diagnosticando COVID-19. Las 22 mujeres eran primigestas; 14,16,18,20,22,24 tres padecían hipotiroidismo; 14,15,18 4% anorexia 14 y 4% anemia.…”

Section: Factores De Riesgo De La Transmisión Verticalunclassified

Frecuencia y factores de riesgo asociados a la transmisión vertical de COVID-19 en neonatos. Una revisión sistemática

Vidal-Cuevas

Rosado-Pérez

2022

CyRS

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Introducción. La COVID-19 es la enfermedad producida por el SARS-CoV-2 y se contagia debido al contacto con una persona infectada. Durante la pandemia se registraron casos de recién nacidos con SARS-CoV-2, así como mujeres embarazadas que dieron positivo a las pruebas de detección del virus. Sin embargo, no existe información consistente respecto a la posible transmisión vertical de COVID-19 ni sobre los factores asociados. Objetivo. Presentar una síntesis del conocimiento sobre la frecuencia y factores de riesgo de la transmisión vertical de COVID-19 en neonatos, a través de una revisión sistemática. Método. Se realizó una búsqueda sistemática en las plataformas de documentos científicos PubMed, Scopus, Web of Science, LILACS, SciELO y Tesiunam, con las siguiestas palabras clave y siguiente de búsqueda: ("Neonate" OR "Pregnancy") AND ("COVID-19" [Mesh] OR "coronavirus") AND ("Vertical transmission") AND ("PCR") entre las publicaciones disponibles hasta el 2 de enero del 2022. Resultados. Se encontraron 279 artículos de los cuales 26 cumplieron con los criterios de elegibilidad, 12 estudios de cohorte y 14 casos clínicos, para la revisión sistemática. En este sentido, los estudios analizados sumaron un total de 1777 madres embarazadas que dieron positivo a las pruebas PCR de COVID-19; al finalizar el embarazo se reportó un nacimiento de 1775 neonatos, de los cuales 2.1% dieron positivo para SARS-CoV2. Para los casos clínicos se analizaron 22 madres embarazadas, de las cuales, seis eran primigestas, tres padecían hipotiroidismo, una anorexia y una anemia; sin embargo, estas características previas no son suficientes para relacionarlas y catalogarlas como un factor de riesgo. Conclusión. Nuestros resultados sugieren que la frecuencia de la transmisión vertical de COVID-19 es de dos por cada cien mujeres embarazas; sin embargo, es necesario llevar a cabo más estudios para confirmar los resultados.

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An Assumed Vertical Transmission of SARS-CoV-2 During Pregnancy: A Case Report and Review of Literature

Cited by 6 publications

References 12 publications

Pregnancy and Childbirth in the COVID-19 Era—The Course of Disease and Maternal–Fetal Transmission

Pregnancy and Childbirth in the COVID-19 Era—The Course of Disease and Maternal–Fetal Transmission

Possible Vertical Transmission From an Unsuspected SARS-CoV-2-Infected Mother to Her Newborn

Frecuencia y factores de riesgo asociados a la transmisión vertical de COVID-19 en neonatos. Una revisión sistemática

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