An Astroblastoma Mimicking a Cavernous Malformation

Tumialán, Luis M.; Brat, Daniel J.; Fountain, Arthur J.; Barrow, Daniel L.

doi:10.1227/01.neu.0000255336.80285.70

Cited by 19 publications

(16 citation statements)

References 22 publications

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“…These features resemble a CCM. This case together with other reports [10][11][12][13][14] might suggest an oncogenetic feature of glioblastoma. This indicates that some gliomas may develop from CCM.…”

Section: Discussionsupporting

confidence: 84%

“…This indicates that some gliomas may develop from CCM. Recently, many reports [10][11][12][13][14][15][16][17] have indicated that there may be a relationship between CCM and intracranial tumors such as glioma, meningioma, and schwannoma. There also have been some reports of glioblastoma presenting as suspected arteriovenous malformation [1,10] .…”

Section: Discussionmentioning

confidence: 99%

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Cerebral glioblastoma mimicking a cavernous malformation: A case report and literature review

Zhang

Zuo

2017

Transl. Neurosci. Clin.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Cerebral glioblastoma mimicking a cavernous malformation: A case report and literature review

Zhang

Zuo

2017

Transl. Neurosci. Clin.

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“…Hemorrhagic appearance is not uncommon; there are three reported cases in which radiologic presentation was confused with vascular etiologies because the initial presentation was acute hemorrhage. [12231] Differential diagnoses in imaging are ependymoma, primitive neuroectodermic tumor, and atypical rhabdoid-teratoid tumor. [4]…”

Section: Discussionmentioning

confidence: 99%

High-grade astroblastoma in a child: Report of one case and review of literature

Vh¹,

Aa²,

Fp³

et al. 2014

Surg Neurol Int

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Background:Astroblastoma is a rare glial neoplastic lesion that affects children and adolescents; its histogenesis remains uncertain. It is considered to account for 0.5% of all glial neoplasms, and two different subtypes have been defined based upon histologic characteristics.Case Description:We present the case of a 9-year-old girl who presented with headache, motor symptoms, and seizures few days before she was admitted to our institution. Computed tomography (CT) and magnetic resonance imaging (MRI) scans showed an intra-axial heterogeneous frontoparietal lesion with a striking “bubbly” appearance in MRI T2-weighted sequences and features of intracranial hypertension. Gross total resection of the tumor was achieved and the histopathologic diagnosis revealed high-grade astroblastoma. We reviewed the current published cases of astroblastoma to highlight the demographic, clinical, radiologic, and pathologic data.Conclusion:Astroblastomas are a distinct clinicopathologic entity, with well-described radiologic, pathologic, and cytogenetic features. Its recurrence is high and efforts must be made to elucidate the role and usefulness of radiotherapy and chemotherapy in these tumors.

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“…Acute hemorrhage as the initial presentation of astroblastoma is a rare occurrence [12]. Brain tumors in general are an uncommon cause of acute brain hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

“…Primary brain tumors such as glioblastoma and anaplastic astrocytoma may also be associated with brain hemorrhage, although less frequently than metastatic lesions [14]. Only one previous report has described hemorrhage in association with astroblastoma (low-grade), which was initially thought to be a cavernous malformation based on imaging studies [12]. As mentioned earlier, the patient in this report experienced significant postoperative complications including venous thromboses in both the upper and lower extremities prompting low-dose heparin therapy and the insertion of an inferior vena cava filter.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Astroblastoma Presenting as Massive, Sudden-Onset, Intraparenchymal Hemorrhage

Johnson¹,

Bonnin²,

Boaz

et al. 2010

Pediatr Neurosurg

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Astroblastoma is a rare primary glial tumor of children and young adults, typically located in the cerebral hemispheres and presenting as a well-circumscribed, nodular, often cystic enhancing mass. The existence of astroblastoma as a distinct clinicopathologic entity has long been debated but is recognized in the 2007 WHO classification of CNS tumors. The grading of these tumors remains unsettled. Currently, no grade has been established and there are no clearly defined diagnostic criteria for low- or high-grade tumors. Astroblastomas in general are thought to have a favorable outcome with low rates of recurrence following gross total resection. We report a case of astroblastoma with ‘high-grade/anaplastic’ histology in a 12-year-old, previously healthy girl. The patient experienced severe, sudden-onset headache, and quickly became comatose. Head CT showed a massive intraparenchymal hemorrhage in the right frontal lobe with surrounding edema. She underwent emergent posterior frontal craniotomy for decompression and hematoma evacuation. Pathologic examination revealed a sharply demarcated hemorrhagic heterogeneous glial tumor with focal papillary architecture, densely hyalinized blood vessels, and intensely GFAP-positive perivascular cells. The tumor showed unequivocal high-grade features including an elevated proliferative index. The diagnosis of anaplastic astroblastoma was rendered. The patient expired on postoperative day 30. This case illustrates the potential poor outcome of high-grade astroblastoma and highlights the morphologic heterogeneity of this rare neoplasm.

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An Astroblastoma Mimicking a Cavernous Malformation

Cited by 19 publications

References 22 publications

Cerebral glioblastoma mimicking a cavernous malformation: A case report and literature review

Cerebral glioblastoma mimicking a cavernous malformation: A case report and literature review

High-grade astroblastoma in a child: Report of one case and review of literature

Anaplastic Astroblastoma Presenting as Massive, Sudden-Onset, Intraparenchymal Hemorrhage

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