This paper presents two kinds fully differential operational transconductance amplifier (OTA) circuit, one is a flipped voltage follower circuit structure (OTA1), the other is a source follow circuit structure (OTA2). The two OTAs' transconductance can all be accurately set by the control voltage. Two Gm-C Low-Pass Filters are designed respectively based on the two OTAs, the filters are the 4th order Butterworth low-pass filter by 2 Biquads,and their cutoff frequency are 100kHz. Simulation is designed in Cadence using SMIC 0.13μm CMOS technology, the supply voltage is 1.2V, the bias current is set to 7.2μA and the common mode voltage is set to 0.6V. The results show that the transconductance values have good linearity in specified range of the input voltage, and the Gm-C filters can all meet the design requirements.