Krein approach is used to study the particle creation during quasi-de Sitter inflation in different background space-times. In the conventional method for calculating the created particles spectrum, the background space-time is automatically considered flat. Selecting a flat background poses two fundamental problems: First, the method of calculating is not covariant relative to the curved space-time. Second, the number of created particles becomes negative. Krein approach can be considered as a covariant method to calculate two-point functions in curved space-time. So we extend this method for particle creation during early cosmic inflation. As a new proposal, we choose the background vacuum based on the smallest number of created particles in that space-time. The calculations in covariant approach will show that in order to solve the above second mentioned problem, the background space-time must be non-flat and the number of particles in the background must be minimum.