An atlas of the heterogeneous viscoelastic brain with local power-law attenuation synthesised using Prony-series

Oisin, Morrison,; Destrade, Michel; Tripathi, B. B.

doi:10.1016/j.actbio.2023.07.040

Cited by 2 publications

(1 citation statement)

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“…Since the theory of this model is linear viscosity hypothesis, it cannot fully describe the nonlinear viscoelastic behavior of various biological soft tissues ( Shetye et al, 2014 ). However, Prony series is widely used and proved to be a constitutive equation that can effectively express the viscoelasticity of materials ( Grega et al, 2020 ; Shearer et al, 2020 ; Li et al, 2021 ; Morrison et al, 2023 ). In this study, R 2 and NRMSE obtained by fitting the experimental data of stress relaxation of patellar tendon before and after treatment showed that Prony series had a good fitting effect and was suitable for this study.…”

Section: Discussionmentioning

confidence: 99%

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

Liu,

Deng,

Liang

et al. 2024

Front. Bioeng. Biotechnol.

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Background: The treatment of patellar tendon injury has always been an unsolved problem, and mechanical characterization is very important for its repair and reconstruction. Elastin is a contributor to mechanics, but it is not clear how it affects the elasticity, viscoelastic properties, and structure of patellar tendon.Methods: The patellar tendons from six fresh adult experimental pigs were used in this study and they were made into 77 samples. The patellar tendon was specifically degraded by elastase, and the regional mechanical response and structural changes were investigated by: (1) Based on the previous study of elastase treatment conditions, the biochemical quantification of collagen, glycosaminoglycan and total protein was carried out; (2) The patellar tendon was divided into the proximal, central, and distal regions, and then the axial tensile test and stress relaxation test were performed before and after phosphate-buffered saline (PBS) or elastase treatment; (3) The dynamic constitutive model was established by the obtained mechanical data; (4) The structural relationship between elastin and collagen fibers was analyzed by two-photon microscopy and histology.Results: There was no statistical difference in mechanics between patellar tendon regions. Compared with those before elastase treatment, the low tensile modulus decreased by 75%–80%, the high tensile modulus decreased by 38%–47%, and the transition strain was prolonged after treatment. For viscoelastic behavior, the stress relaxation increased, the initial slope increased by 55%, the saturation slope increased by 44%, and the transition time increased by 25% after enzyme treatment. Elastin degradation made the collagen fibers of patellar tendon become disordered and looser, and the fiber wavelength increased significantly.Conclusion: The results of this study show that elastin plays an important role in the mechanical properties and fiber structure stability of patellar tendon, which supplements the structure-function relationship information of patellar tendon. The established constitutive model is of great significance to the prediction, repair and replacement of patellar tendon injury. In addition, human patellar tendon has a higher elastin content, so the results of this study can provide supporting information on the natural properties of tendon elastin degradation and guide the development of artificial patellar tendon biomaterials.

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Section: Discussionmentioning

confidence: 99%

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

Liu,

Deng,

Liang

et al. 2024

Front. Bioeng. Biotechnol.

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Comparative Biomechanical Studies of Goat and Human Brain Applicable for Surgical Training

Gautam,

Narwal,

Kaushik

et al. 2024

Preprint

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Background Haptics-based neurosurgical simulators play a paramount role in surgical training. The reliability of these simulators depends on the accurate mechanical response of brain tissue. However, no study has yet provided a comprehensive mechanical map of the whole brain, which is crucial for an in-depth understanding of brain mechanics. Methods In our study, we elucidated the viscoelastic behaviour of the whole brain in 12 goat brains and one human brain using dynamic nanoindentation. This involved comparing the mechanical properties of corresponding goat brain regions to human brain regions. Results The cortex gray matter (GM) in the goat brain was approximately 30% stiffer than its white matter (WM), whereas deep GM in the thalamus was 23% stiffer than the deep WM in the corpus callosum. Interestingly, the human brain GM was up to 150% stiffer than the goat brain GM; however, the human brain WM stiffness showed the same range as that of goat brain WM. The stiffness of the midbrain, pons, and medulla oblongata of the brain stem in humans and goats showed no significant difference. The loss moduli did not vary significantly across the brain. Additionally, the formalin fixation doubled the brain tissue stiffness. Conclusion Our study revealed a significant regional heterogeneity in the mechanical characteristics of brain tissue. We found that the GM was consistently stiffer than WM in both goat and human brains and that the human brain GM was stiffer than the goat brain GM. These findings have important implications for understanding brain biomechanics and for developing reliable and comprehensive neurosurgical training platforms.

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An atlas of the heterogeneous viscoelastic brain with local power-law attenuation synthesised using Prony-series

Cited by 2 publications

References 138 publications

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

Comparative Biomechanical Studies of Goat and Human Brain Applicable for Surgical Training

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