Infrastructure networks are critical components of contemporary society, and numerous approaches have been suggested for the selection of strategies to protect these networks. However, for uncertain environments, research on attack and defense game models for infrastructure networks is limited. Therefore, after reviewing the existing approaches, a method based on interval-valued intuitionistic fuzzy set (IVIFS) theory is proposed for attack and defense games in critical infrastructure networks. First, we present the process of constructing the game model proposed in this paper, which mainly includes the formulation of the cost model, the strategies, and the method of generating IVIFS payoffs. Next, the Nash equilibria of the game are identified by a pair of nonlinear programming models based on IVIFS theory. Finally, experiments are conducted on a target scale-free network, and an investigation into the variation patterns of the Nash equilibria under different circumstances is also conducted. We provide explanations for these variation patterns by considering payoffs from the perspective of mathematical programming models. Furthermore, we find that compared to the existing attack and defense game model with crisp payoffs, the model proposed in this paper leads to superior Nash equilibria. Our work is a preliminary attempt to analyse attack and defense games for infrastructure networks based on IVIFS theory, providing a method for assessing payoffs in uncertain environments for the attacker and defender. This topic deserves further study.