An attempt to replace an ivermectin-resistant Cooperia spp. population by a susceptible one on grazing pastures based on epidemiological principles and refugia management

Fiel, César; Steffan, Pedro; Muchiut, Sebastián; Fernández, A.; Bernat, G.; Riva, Eliana; Lloberas, Mercedes; Almada, A.; Homer, David

doi:10.1016/j.vetpar.2017.08.026

Cited by 19 publications

(11 citation statements)

References 20 publications

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“…Although this is a particular risk in intensive livestock farming, selection pressures may be reduced in populations where there is no importation of resistant parasites, treatment is temporally or spatially limited and anthelminthic classes are rotated to reduce selection pressure. These measures can be so effective that, with careful management, ivermectin efficacy can be restored even in intensively farmed herds [47].…”

Section: Discussionmentioning

confidence: 99%

Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea

Pasay

Yakob²,

Meredith³

et al. 2019

Parasites Vectors

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BackgroundOutdoor, early-biting, zoophagic behaviours by Anopheles farauti (s.s.) can compromise the effectiveness of bed nets for malaria control. In the Western Pacific region, pigs and dogs represent significant alternative blood sources for mosquitoes. Treating these animals with endectocides may impact mosquito survival and complement control measures. This hypothesis was explored using membrane feeding assays (MFAs), direct feeds on treated pigs, pharmacokinetic analyses and a transmission model.ResultsIvermectin was 375-fold more mosquitocidal than moxidectin (24 h LC50 = 17.8 ng/ml vs 6.7 µg/ml) in MFAs, and reduced mosquito fecundity by > 50% at ≥ 5 ng/ml. Treatment of pigs with subcutaneous doses of 0.6 mg/kg ivermectin caused 100% mosquito mortality 8 days after administration. Lethal effects persisted for up to 15 days after administration (75% death within 10 days).ConclusionThe application of these empirical data to a unique malaria transmission model that used a three-host system (humans, pigs and dogs) predicts that the application of ivermectin will cause a significant reduction in the entomological inoculation rate (EIR = 100 to 0.35). However, this is contingent on local malaria vectors sourcing a significant proportion of their blood meals from pigs. This provides significant insights on the benefits of deploying endectocides alongside long-lasting insecticide-treated nets (LLINs) to address residual malaria transmission.Electronic supplementary materialThe online version of this article (10.1186/s13071-019-3392-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea

Pasay

Yakob²,

Meredith³

et al. 2019

Parasites Vectors

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“…the proportion of the worm population not exposed to anthelmintics which is outside the host as free-living stages or in untreated animals (Van Wyk 2001), that can help to dilute the resistant population and hence delay the onset of AR. A recent study reported the successful introduction of susceptible parasites into a farm with a high proportion of resistant nematodes, resulting in an increased drug efficacy after two years of introducing the susceptible worms (Fiel et al 2017). Another strategy to ensure a refugia population is the targeted selective treatment (TST) of the animals in need of anthelmintic drenching, instead of treating the whole herd .…”

Section: Perspectives and Further Researchmentioning

confidence: 99%

Drug resistance in parasitic helminths of veterinary importance in Chile: Status review and research needs

Pena-Espinoza

2018

Austral j. vet. sci.

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The increasing development of anthelmintic resistance (AR) in parasites of livestock is threatening animal health and production worldwide. In Chile, studies evaluating the field efficacy of anthelmintics and the detection of AR have been performed since the 2000s, but until now, no previous attempt has tried to systematise the available information. This article reviews general concepts about AR in helminths of veterinary importance, methods for diagnosis of AR and summarises the published reports of AR in Chile. Anthelmintic resistance in Chile has been reported in gastrointestinal nematodes of horses (benzimidazole resistance) and ruminants (sheep and cattle, macrocyclic lactone and benzimidazole resistance). However, these cases involved a limited number of selected farms and no further conclusions can be made of the status of parasite drug resistance at a regional or national level. No published cases of AR in Fasciola hepatica have been reported in Chilean livestock, but human infections with triclabendazole-resistant F. hepatica have been described in patients with previous consumption of watercress or untreated water from marshes grazed by livestock. Given the zoonotic potential and endemic nature of F. hepatica in Chile, it is urgent to determine the extent of liver fluke resistance. Current research gaps of the situation of AR in Chile and suggestions for the performance of laboratory and field studies are further discussed.

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“…Chemoresistance is a concern in the management of gastrointestinal helminths [ 8 , 9 , 10 ]. This phenomenon has been recognized for more than 50 years [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Research on the Control of Gastrointestinal Strongyles in Sheep by Using Lotus corniculatus or Cichorium intybus in Feed

Cireșan,

Cocan,

Alexa

et al. 2023

Pathogens

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The general practice of sheep farmers in gastrointestinal helminth control is based on the use of commercial drugs, making chemoresistance very common. Considering this, our study focused on the biological control of gastrointestinal parasitism using high-tannin plant hay. Three groups of 30 animals each were formed. The control group was additionally fed meadow hay, while the other two groups received chicory (group 2) and bird’s foot trefoil hay (group 3). The number of gastrointestinal strongyle eggs, shed through faeces (EPG), was surveyed for 28 days for all animals. The amounts of total tannins for meadow, chicory, and Lotus corniculatus hay supplements were 13.92 mg/g, 78.59 mg/g, and 94.43 mg/g, while their condensed tannin contents were 2.58 mg/g, 29.84 mg/g, and 15.94 mg/g, respectively. Compared to experimental day 0, there was an increase in EPG of 80.83% in the control group, a decrease of 24.72% in group 2, and a 20% decrease in group 3, by day 28. The p-value was <0.05 between group 1 and the other groups, showing significant differences between the control and experimental groups. The decrease in EPG rates in the experimental groups compared to the control group demonstrates an antiparasitic effect of Lotus corniculatus and chicory.

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An attempt to replace an ivermectin-resistant Cooperia spp. population by a susceptible one on grazing pastures based on epidemiological principles and refugia management

Cited by 19 publications

References 20 publications

Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea

Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea

Drug resistance in parasitic helminths of veterinary importance in Chile: Status review and research needs

Research on the Control of Gastrointestinal Strongyles in Sheep by Using Lotus corniculatus or Cichorium intybus in Feed

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