An Atypical Outbreak of Food-Borne Botulism Due to Clostridium botulinum Types B and E from Ham

Mazuet, Christelle; Sautereau, Jean; Legeay, Christine; Bouchier, Christiane; Bouvet, P.; Popoff, Michel R.

doi:10.1128/jcm.02942-14

Cited by 26 publications

(29 citation statements)

References 27 publications

(23 reference statements)

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“…Genetic analysis of the strains producing BoNT/E9 and /E12 indicates that their genomes are more closely related to the Group II BoNT/B4 Eklund 17B strains than to other serotype E strains (Mazuet et al, 2015;Raphael et al, 2012).…”

Section: Bont/ementioning

confidence: 99%

“…butyricumGroup VI type E strains and consists of 12 subtypes. The BoNT/E1-E12 proteins vary by up to 11% (Mazuet et al, 2015;Smith, 2014;Weedmark et al, 2014).Serotype E strains are almost always isolated in northern geographic regions, such as Alaska/Canada, northern Japan, and the Baltic Sea region. A notable exception was the BoNT/E9-producing strain CDC 66177 (Raphael et al, 2012), which was isolated from the environment in southern Argentina.…”

Section: Bont/ementioning

confidence: 99%

“…More recently, BoNT/E10 and BoNT/E11 strains were isolated from the eastern region of Hudson Bay and Ungava Bay (E10) or in the vicinity of the Koksoak River (E11) in Canada (Weedmark et al, 2014). The BoNT/E12 strain was recently identified from a foodborne botulism case in France (Mazuet et al, 2015).…”

Section: Bont/ementioning

confidence: 99%

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Genetic diversity within the botulinum neurotoxin-producing bacteria and their neurotoxins

Hill

Xie

Foley

et al. 2015

Toxicon

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The recent availability of multiple Clostridium botulinum genomic sequences has initiated a new genomics era that strengthens our understanding of the bacterial species that produce botulinum neurotoxins (BoNTs). Analysis of the genomes has reinforced the historical Group I-VI designations and provided evidence that the bont genes can be located within the chromosome, phage or plasmids. The sequences provide the opportunity to examine closely the variation among the toxin genes, the composition and organization of the toxin complex, the regions flanking the toxin complex and the location of the toxin within different bacterial strains. These comparisons provide evidence of horizontal gene transfer and site-specific insertion and recombination events that have contributed to the variation observed among the neurotoxins. Here, examples that have contributed to the variation observed in serotypes A-H strains are presented to illustrate the mechanisms that have contributed to their variation.

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Section: Bont/ementioning

confidence: 99%

Section: Bont/ementioning

confidence: 99%

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Genetic diversity within the botulinum neurotoxin-producing bacteria and their neurotoxins

Hill

Xie

Foley

et al. 2015

Toxicon

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“…The other cluster includes subtype B4 strains and type E strains (Figure 2, panel b). This includes type E strains, isolated in France and Argentina [43•, 57, 58], that form neurotoxin subtype E9 or E12 (two closely related neurotoxins that are separate from other type E neurotoxins — Figure 1). Three further type E strains isolated from a food sample (whale meat) collected during a foodborne botulism outbreak are also closely related to type B strains [43•, 54•].…”

Section: Genomic Diversity Of Clostridium Botulinum Group IImentioning

confidence: 99%

Impact of Clostridium botulinum genomic diversity on food safety

Peck

Vliet

2016

Current Opinion in Food Science

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“…The fish was from Canada and was processed in Finland [134]. In 2010, an unusual case resulted from a ham contaminated with C. botulinum B and a novel C. botulinum E subtype (E12) [135,138]. It was hypothesized that marine salt used for the ham preparation could be the origin of the contamination.…”

Section: Foodborne Botulismmentioning

confidence: 99%

Botulinum Toxins, Diversity, Mode of Action, Epidemiology of Botulism in France

Popoff¹

2018

Botulinum Toxin

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Botulinum toxins (BoNTs) are the most potent toxins and are responsible for botulism, which is a neurological disease in man and animals. Botulism is characterized by flaccid paralysis and inhibition of secretions. BoNTs are produced by distinct clostridial species including Clostridium botulinum that consist in four physiological and genetic groups, atypical strains of C. baratii and C. butyricum. Recently, nonclostridial bacteria have been found to synthesize BoNTs. The particularity of BoNTs is to associate with nontoxic proteins to form large-size complexes that are resistant to acidic pH and protease degradation of the digestive tract. BoNTs are divided into 10 types based on neutralization by specific antisera and into more than 40 subtypes according to their sequence variations. All BoNTs retain a common core structure and mode of action, which consists in the inhibition of neurotransmitter release, notably acetylcholine. Human botulism occurs in three main forms: foodborne botulism, botulism by intestinal colonization including infant botulism, and wound botulism. In France, type B foodborne botulism is the most prevalent form, resulting from the traditional consumption of pork products such as home-made cured ham. Albeit less frequent, human botulism is still present in France including diverse types and origins.

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An Atypical Outbreak of Food-Borne Botulism Due to Clostridium botulinum Types B and E from Ham

Cited by 26 publications

References 27 publications

Genetic diversity within the botulinum neurotoxin-producing bacteria and their neurotoxins

Genetic diversity within the botulinum neurotoxin-producing bacteria and their neurotoxins

Impact of Clostridium botulinum genomic diversity on food safety

Botulinum Toxins, Diversity, Mode of Action, Epidemiology of Botulism in France

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