An atypical presentation of malaria in a 19-year-old woman

Malhotra, Radhika; Manoharan, Anjella; Nyaku, Amesika; Castro, D. Mosquera

doi:10.1016/j.idcr.2022.e01378

Cited by 2 publications

(2 citation statements)

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“…To explore these relationships, children with malaria and those without malaria were comparable in terms of age and gender distributions. This study confirmed the direct relationships between malaria parasitemia and fever 21 , 35 , 36 and derangements of hematological parameters 30 , 37 , 38 , 39 as has been widely published. The mean temperature reading of the malaria patients was 38.78 ± 1.39°C with a significant reduction in erythrocytes, hemoglobin, hematocrit, platelet levels, mean platelet volume, and plateletcrit.…”

Section: Discussionsupporting

confidence: 89%

“…34 To explore these relationships, children with malaria and those without malaria were comparable in terms of age and gender distributions. This study confirmed the direct relationships between malaria parasitemia and fever 21,35,36 and derangements of hematological F I G U R E 2 Stratification of thyroid hormones by sex. (A) TSH levels in male malaria cases, (B) TSH levels in female malaria cases, (C) fT3 levels in male malaria cases, (D) fT3 levels in female malaria cases, (E) fT4 levels in male malaria cases, (F) fT4 levels in female malaria cases.…”

Section: Discussionsupporting

confidence: 80%

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Elevation of free triiodothyronine (fT3) levels by Plasmodium falciparum independent of thyroid stimulating hormone (TSH) in children with uncomplicated malaria

Kwansa‐Bentum,

Aninagyei,

Adedia

et al. 2024

Clinical Laboratory Analysis

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BackgroundMalaria parasites have a devastating effect on the infected host. However, there is a paucity of data on the effect of Plasmodium falciparum on thyroid hormones.MethodsThis case–control study (1:1) involved children <16 years of age with uncomplicated malaria. Hematological parameters were determined using the URIT‐5380 hematology analyzer (China). Later, levels of thyroid hormones, namely free triiodothyronine (fT3), free tetraiodothyronine (fT4), and thyroid‐stimulating hormone (TSH), were determined using human ELISA kits (DiaSino ELISA kit, Zhengzhou, China).ResultsNinety children with malaria and ninety matched control group were studied. Overall, compared to the control group, lower TSH (3.43 ± 1.25 vs. 3.84 ± 1.34, p = 0.035) and elevated levels of fT3 levels (5.85 ± 1.79 vs. 3.89 ± 1.19, p < 0.001) were observed in patients with malaria. However, fT4 levels were comparable between cases and control group (16.37 ± 2.81 vs 17.06 ± 3.5, p = 0.150). Free T3 levels were significantly higher in children <10 years (p < 0.001) and higher among male children with malaria (p < 0.001). Overall, there was a significant positive relationship between parasite counts and fT3 (R = 0.95, p < 0.001). Furthermore, body temperature was positively correlated with fT3 (R = 0.97, p < 0.001).ConclusionsIsolated fT3 thyrotoxicosis was observed in falciparum malaria, especially in children <10 years and male malaria patients, independent of TSH. This observation could explain the severity of malaria in children.

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