An atypical variant of phacomatosis pigmentokeratotica: verrucous epidermal nevus, speckled lentiginous nevus, and Spitz nevus associated with scoliosis

Fan, Yi‐Ming; Liu, Zhen; Zhu, Cheng-Yao; Li, Wen; Li, Shun-Fan

doi:10.1111/j.1365-4632.2012.05599.x

Cited by 4 publications

(1 citation statement)

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“…[106][107][108][109] Follow-up for musculoskeletal anomalies, including scoliosis, limb hypertrophy, may be also suitable. 110 However, the full spectrum of cutaneous and extracutaneous features of PPK has not been delineated yet. For this reason, it is necessary, after the diagnosis of PPK, to inform the patient or the parents of the importance of a careful follow-up to notice any of the previously reported features or any other possible associations that are so far unknown.…”

Section: Follow-up and Managementmentioning

confidence: 99%

Phacomatosis Pigmentokeratotica

et al. 2018

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In the group of the epidermal nevus syndromes, Happle defined in 1996 a separate entity characterized by the presence of an organoid epidermal nevus, sometimes showing sebaceous differentiation, and a speckled lentiginous nevus of the papular type, occasionally associated with extracutaneous anomalies including neurological, ophthalmological, and skeletal abnormalities. In particular, the syndrome is associated with mental retardation, epilepsy, deafness, hemiatrophy, dysesthesia, and hyperhidrosis, strabismus, lipodermoid of conjunctiva, coloboma and ptosis, and kyphosis, scoliosis, limb asymmetry, and hypertrophy. Rarely, hypertension, vascular abnormalities, atrioventricular block, hypophosphatemic rickets, and pheochromocytoma may occur. The organoid nevus follows the lines of Blaschko whereas the speckled lentiginous nevus is arranged in a checkerboard pattern. For this syndrome, the term “Phacomatosis Pigmentokeratotica” has been coined and, at the present, it is considered a very rare clinical entity, with less than 20 cases reported in the literature. Recent genetic findings have included this syndrome in the group of the mosaic RASopathies, after the discovery of mutations in the HRAS gene occurring in both sebaceous and vascular nevi, but not in nonaffected tissues.

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