An Autologously Generated Platelet-Rich Plasma Suturable Membrane May Enhance Peripheral Nerve Regeneration after Neurorraphy in an Acute Injury Model of Sciatic Nerve Neurotmesis

Giannessi, Elisabetta; Coli, Alessandra; Stornelli, Maria Rita; Miragliotta, Vincenzo; Pirone, Andrea; Lenzi, Carla; Burchielli, Silvia; Vozzi, Giovanni; Maria, Carmelo De; Giorgetti, Margherita

doi:10.1055/s-0034-1372483

Cited by 55 publications

(36 citation statements)

References 25 publications

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“…Giannessi et al . 13 commented that PRP could be a nerve guide to diminish scar reaction during axonal regeneration in a rat sciatic nerve model. Another study revealed that PRP could limit nerve damage 12 weeks post-injection in a rabbit model of 10% dextrose-induced MN injury (carpal tunnel model) 14 .…”

Section: Discussionmentioning

confidence: 99%

Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trial

Wu¹,

Ho²,

Chou³

et al. 2017

Sci Rep

163

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Recently, a few small reports with short follow-up period have shown clinical benefits of platelet-rich plasma (PRP) for peripheral neuropathy including one pilot study and one small, non-randomized trial in patients with carpal tunnel syndrome (CTS). Therefore, we conducted a randomized, single-blind, controlled trial to assess the 6-month effect of PRP in patients with CTS. Sixty patients with unilateral mild-to-moderate CTS were randomized into two groups of 30, namely the PRP and control groups. In the PRP group, patients were injected with one dose of 3 mL of PRP using ultrasound guidance and the control group received a night splint through the study period. The primary outcome measure was the visual analog scale (VAS) and secondary outcome measures included the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) score, the cross-sectional area (CSA) of the median nerve (MN), electrophysiological findings of the MN, and finger pinch strength. The evaluation was performed before treatment and at 1, 3, and 6 months post-injection. The PRP group exhibited a significant reduction in the VAS score, BCTQ score, and CSA of MN compared to the those of control group 6 months post-treatment (p < 0.05). Our study demonstrates that PRP is a safe modality that effectively relieves pain and improves disability in the patients with CTS.

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Section: Discussionmentioning

confidence: 99%

Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trial

Wu¹,

Ho²,

Chou³

et al. 2017

Sci Rep

163

View full text Add to dashboard Cite

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“…Among all, the issue here is about the effect of PRP on neural tissue and the concern of its effectiveness in the management of peripheral neuropathies and the relief of NP. Studies arguing in favor of the use of PRP in neuropathies and/or NP, consider that PRP or stem cells can exert an anti-inflammatory effect through cytokine release, and consider the role of PRP or stem cells in nerve healing and regeneration, combating thus the pathological inflammation involved in neuropathic pain (53)(54)(55)(56)(57). This …”

Section: Current Schemes Treatments For Np and Our Cell-based Proposalmentioning

confidence: 99%

Platelet-rich plasma in treating peripheral neuropathic pain. Preliminary report

Lopez¹,

Cortes²,

García-Ceballos³

et al. 2017

Rev. Soc. Esp. Dolor.

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“…PRP products hold an important therapeutic potential as a neuroprotective, neurogenic and neuroinflammatory therapeutic modulator system [46][47][48][49][50] and as enhancer of sensory and motor functional nerve-muscle unit recovery [51][52][53]. They are applied either as a filler of nerve conduits or vein-muscle grafts across nerve gaps post-trauma by ultrasound-guided perineural and intraneural infiltrations or as scaffolds to bridge or wrap the injured nerve stumps [54][55][56].…”

Section: Prp In the Management Of Neuropathiesmentioning

confidence: 99%

PRP Injections in Orthopaedic Surgery: Why, When and How to Use PRP Dynamic Liquid Scaffold Injections in Orthopaedic Surgery

Sánchez¹,

Delgado²,

Garate³

et al. 2018

Plasma Medicine - Concepts and Clinical Applications

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Platelet-rich plasma (PRP) products can be described as any autologous blood platelet concentrate within a plasma suspension. PRP products include plasma and twofold or greater increases in platelet concentrations above baseline levels. The injection of activated PRP in its liquid formulation delivers growth factors locally and simultaneously mimics and amplifies the spontaneous healing response in injured areas and in special cell niches, which would otherwise be inaccessible. This in situ generated transient threedimensional scaffold will gradually release growth factors and maintain their concentration at the site of the scaffold formation. The combination of liquid PRP with surgical techniques in orthopaedic surgery allows a wide range of therapeutic strategies in the management of injuries in the field of orthopaedics and sports medicine. The use of different therapeutic elements, including PRP as biological stimuli and rehabilitation and physiotherapy treatments as mechanical stimuli, provides extremely favourable synergies that will help fulfil the physician's objective, to stop the progression of disease and to improve function in the shortest period of time

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An Autologously Generated Platelet-Rich Plasma Suturable Membrane May Enhance Peripheral Nerve Regeneration after Neurorraphy in an Acute Injury Model of Sciatic Nerve Neurotmesis

Cited by 55 publications

References 25 publications

Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trial

Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trial

Platelet-rich plasma in treating peripheral neuropathic pain. Preliminary report

PRP Injections in Orthopaedic Surgery: Why, When and How to Use PRP Dynamic Liquid Scaffold Injections in Orthopaedic Surgery

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