An automated fluorometric method for the determination of histamine in biological samples

Martin, Lee; Harrison, C.

doi:10.1016/0006-2944(73)90034-3

Cited by 13 publications

(2 citation statements)

References 4 publications

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“…It was not easy to measure exogenous synthetic glucocorticoids, so suppressed endogenous adrenocorticosteroid hormones were examined. Blood histamine levels in the control group were almost the same as previously reported levels (10). Severe eosinophilia was observed in topical corticosteroid.treated patients before treatment; they had severe skin disease accompanied with symptoms (11).…”

Section: Discussionsupporting

confidence: 84%

Studies of Blood Histamine Levels during Topical Corticosteroid Therapy Compared with Those during Systemically Administered Corticosteroids

Tanaka

1987

The Journal of Dermatology

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Blood histamine levels during topical corticosteroid therapy have not been reported, although decreased blood histamine levels are known to occur after the systemic administration of corticosteroid. Blood histamine levels and serum ll-hydroxycorticosteroids (ll-OHCS) after systemic corticosteroid were compared with those after topical corticosteroid. Both blood histamine and serum ll-OHCS levels decreased in a parallel and dose-dependent manner during systemic administration of 0.5-1.0 mg/day of betamethasone. Blood histamine levels increased and serum ll-OHCS levels decreased during systemic administration of 0.25 mg/day to the betamethasone and topical corticosteroid group. Changes in blood histamine levels in the topical corticosteroid group appeared between 0.25 and 0.5 mg/day of systemically administered betamethasone.Fifteen cases of dermatological inpatients suffering from wide-spread eczema or exfoliative dermatitis were treated with the topical corticosteroids betamethasone 17-valerate, budesonide and diflorasone diacetate. In each case, blood histamine levels were examined and an equipotent dose of oral administeration of betamethasone was calculated. Thirteen cases in whom blood histamine levels were measured fell into the dosage range from 0.1 to 0.5 mg/day.In each case, serum ll-OHCS levels were also examined and an equipotent dose of oral administration of betamethasone was calculated by the same method. Fourteen cases in whom serum ll-OHCS levels were measured compared to a dose of less than 1.0 mg/day of betamethasone. Blood histamine levels in rats treated with 20 or 50 mg/kg/day of prednisolone were decreased significantly, and peripheral total leukocytes, lymphocytes, neutrophils and basophils were also decreased significantly.

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Section: Discussionsupporting

confidence: 84%

Studies of Blood Histamine Levels during Topical Corticosteroid Therapy Compared with Those during Systemically Administered Corticosteroids

Tanaka

1987

The Journal of Dermatology

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“…This reaction is very convenient for quantifying trace amounts of histamine in tissues [1][2][3][4] or food [5]. In order to avoid interference from other biogenic amines or peptides [5,6] a separation step is generally included in the procedure either by extraction [1,3,7,8] or by chromatography [2,9]. In studies on purified mast cells or basophils this separation step is very often omitted (see e.g.…”

Section: Introductionmentioning

confidence: 99%

Dimethyl sulfoxide decreases the fluorescence yield of the reaction between histamine and ortho-phthalaldehyde and may influence histamine release

1988

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A sensitive method for quantifying histamine is the assay based on the fluorescence of the product obtained after reacting the amine with ortho-phthalaldehyde. The presence of dimethyl sulfoxide (DMSO) even in concentrations as low as 1% decreases the yield of fluorescence. Neglecting this quenching leads to the erroneous conclusion that DMSO in a concentration dependent manner inhibits the thapsigargin induced histamine release from peritoneal rat mast cells. Apart from the release induced by the selective calcium ion mobilizers thapsigargin and ionophore A23147, DMSO potently inhibits the response to other secretagogues.

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Zur Umsetzung von Phthalaldehyd mit Aminen, 3. Mitt. Synthese von 5,7‐Dihydropyrido[2′,3′:4,5]pyrimido[2,1‐a]isoindolen

Troschütz

Söllhuber‐Kretzer

1985

Archiv der Pharmazie

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Phthalaldehyd (7) und 3,4-Dimethoxyphthalaldehyd (8) reagieren im sauren Milieu mit den Pyridindiaminen 6a und 6b zu den Titelverbindungen. Pyrido[3',2' : 5,6]pyrimido[2,1-a]isoindolone entstehen aus 7 bzw. 8 und dem 2-Aminonicotinsaureamid Is.Reactions of Phthalaldehyde with Amines, III: Synthesis of 5,7-Dihydmpyrido[2',3' : 4,5]pyrimido[2,1-a]WidolesPhthalaldehyde (7) and 3,4-dimethoxyphthalaldehyde (8) react with pyridinediamines 6. and 6b in acidic medium to yield the title compounds. Pyrido[3' ,2' : 5,6]pyrimido[2,l-a]isoindolones are synthesized from 7 or 8 and the 2-aminopyridine-3-carboxamide Is. Phthalaldehyd (7) wird haufig zum fluorimetrischen Nachweis von biogenen Aminen'), Aminosauren') und Ind~lderivaten~) herangezogen. Aromatische Amine reagieren mit 7 unter geeigneten Bedingungen zu Phthali~nidinen~). Wie kiirzlich berichtet wurde, setzt sich 7 mit Diaminen vom Typ des 2-Aminobenzylamins im sauren Milieu unter Doppelringschlul3 zu 5,ll-Dihydro-isoindolo[2,1-a]chinazolinen urns). Durch Variation der Aldehydkomponente einerseits und der Aminkomponente andererseits sollten durch diese zweifache Cyclokondensation neuartige mehrkernige Heterocyclen zuganglich sein. Zunachst interessierte die Umsetzung von 7 mit Diaminen vom Pyridintyp.

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An automated fluorometric method for the determination of histamine in biological samples

Cited by 13 publications

References 4 publications

Studies of Blood Histamine Levels during Topical Corticosteroid Therapy Compared with Those during Systemically Administered Corticosteroids

Studies of Blood Histamine Levels during Topical Corticosteroid Therapy Compared with Those during Systemically Administered Corticosteroids

Dimethyl sulfoxide decreases the fluorescence yield of the reaction between histamine and ortho-phthalaldehyde and may influence histamine release

Zur Umsetzung von Phthalaldehyd mit Aminen, 3. Mitt. Synthese von 5,7‐Dihydropyrido[2′,3′:4,5]pyrimido[2,1‐a]isoindolen

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