An automated framework to quantify areas of regional ischemia in retinal vascular diseases with OCT angiography

Anegondi, Neha; Chidambara, Lavanya; Bhanushali, Devanshi; Gadde, Santosh Gopi Krishna; Yadav, Naresh Kumar; Roy, Abhijit Sinha

doi:10.1002/jbio.201600312

Cited by 10 publications

(4 citation statements)

References 23 publications

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“…Presently, there is growing interest in the quantitative analysis of the microvascular architecture following the introduction of OCT-A and its ability to perform high resolution imaging of the retinal microvasculature. Studies applying FD analysis in retinal microvascular diseases (diabetic retinopathy and RVO) have demonstrated significant changes even early in the disease process 15–17. In RVO, reproducible and reliable quantitative analysis of the microvasculature would be very helpful for evaluating disease severity, progression, and response to treatment.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of Peripheral Nonperfusion in Retinal Venous Occlusions Using Optical Coherence Tomography Angiography

Cabral

Coscas

Glacet–Bernard

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose To study the association between the assessment of central macular vascular layers by optical coherence tomography angiography (OCT-A) and peripheral nonperfusion evaluated by fluorescein angiography (FA) in patients with retinal venous occlusion (RVO). Methods Retrospective review of RVO patients without macular edema. Patients underwent a comprehensive ophthalmic examination including FA, spectral-domain OCT, and OCT-A. Significant ischemia was defined as nonperfusion areas superior or equal to the equivalent of one retinal quadrant on FA. Vascular density (VD) and foveal avascular zone were measured using AngioAnalytics software. Fractal dimension (FD) and lacunarity (LAC) were computed using an algorithm designed by MATLAB (MathWorks, Natick, MA). These variables were used to build a model that translates their association with OCT-A parameters. Results There were 48 eyes (48 patients) of which 19 had significant peripheral nonperfusion. Deep capillary plexus FD, VD, and LAC were associated with significant ischemia. In fact, regarding the association with this outcome, LAC alone had the highest area under the curve (AUC = 0.88) followed by FD (AUC = 0.85) and VD (AUC = 0.73). The multivariable model that included LAC and VD, adjusted by best-corrected visual acuity (BCVA) achieved the best performance for the identification of severe nonperfusion on wide-field FA (AUC = 0.93). Conclusions The characteristics of the central macular deep capillary plexus on OCT-A may be associated with peripheral nonperfusion on FA, particularly the combination of LAC and vessel density after adjusting by BCVA. Translational Relevance Fractal-based metrics applied to OCT-A may become a valuable marker of ischemia in RVO and help guide the clinical decision to perform invasive angiography.

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Section: Introductionmentioning

confidence: 99%

Biomarkers of Peripheral Nonperfusion in Retinal Venous Occlusions Using Optical Coherence Tomography Angiography

Cabral

Coscas

Glacet–Bernard

et al. 2019

Trans. Vis. Sci. Tech.

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“…9 Optical coherence tomography angiography (OCTA) is an advanced retinal imaging modality that does not require pupillary dilation or intravenous dye injection and is, therefore, an ideal tool to study vascular eye findings in pregnancy. [10][11][12] In addition, OCTA provides high-contrast depth-resolved visualization of the retinal microvasculature and automated or semiautomated quantitative analysis. OCTA uses decorrelation signals that arise Copyright 2019 The Authors iovs.arvojournals.org j ISSN: 1552-5783 from the movement of erythrocytes within blood vessels taken from sequential B-scans at the same location and can produce en face images of the retinal microcirculation.…”

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confidence: 99%

Retinal Vascular Changes During Pregnancy Detected With Optical Coherence Tomography Angiography

Chanwimol

Balasubramanian

Nassisi

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To evaluate retinal vascular status during pregnancy by using optical coherence tomography angiography (OCTA). METHODS. Women in their third trimester of pregnancy and nonpregnant age-matched women were recruited for this prospective, case-control study. Subjects were imaged with OCTA. Main outcome measures were foveal avascular zone parameters, perfusion density (PD) percentage in the superficial retinal capillary plexus (SCP), PD percentage in the deep retinal capillary plexus (DCP), SCP vessel length density (VLD), DCP-VLD, and choriocapillaris (CC) flow voids (i.e., flow deficits in the CC). RESULTS. Nineteen eyes of 10 pregnant subjects and 44 eyes of 27 nonpregnant control women were included. Mean ages were 36 6 7 and 35 6 8 years (SD), respectively (P value ¼ 0.78). Mean gestational age of pregnant women was 33 weeks (range ¼ 29-39, SD ¼ 3). There was a significant reduction in the SCP-PD in the entire scan and in the nasal Early Treatment Diabetic Retinopathy Study subfield (47.9 vs. 49.7, P ¼ 0.04 and 49.3 vs. 51.6, P ¼ 0.03, respectively) in the pregnant cohort versus controls. There was a significant increase in the DCP-PD in the parafoveal region and in the temporal and inferior Early Treatment Diabetic Retinopathy Study subfields (58.0 vs. 55.9, P ¼ 0.03; 57.9 vs. 55.5, P ¼ 0.02; 58.0 vs. 55.9, P ¼ 0.05, respectively) in the pregnant cohort. There was no significant difference in foveal avascular zone parameters, SCP-VLD, DCP-VLD, or CC flow voids between the two populations. CONCLUSIONS. This study detected retinal vasculature changes in the third trimester of pregnancy. Mean SCP-PD was significantly decreased and mean DCP-PD was significantly increased without a difference in VLD.

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“…Optical coherence tomography angiography (OCTA) is a recently developed noninvasive imaging technique that provides depth-resolved, high-resolution visualization of the retinal microvasculature and automated or semiautomated quantitative analysis without dye injection. It allows us to easily screen the superficial retinal capillary plexus (SCP) and the deep retinal capillary plexus (DCP) [18][19][20][21]. e present study was performed to investigate the retinal vascular changes during the menstrual cycle in healthy reproductive women by OCTA.…”

Section: Introductionmentioning

confidence: 99%

Retinal Vascular Changes during the Menstrual Cycle Detected with Optical Coherence Tomography Angiography

Guo

Zhu

Wang

et al. 2021

Journal of Ophthalmology

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Purpose. To evaluate the effects of the menstrual cycle on the retinal vascular status of healthy women by optical coherence tomography angiography (OCTA). Materials and Methods. Healthy women with regular natural menstrual cycles of 28 to 30 days were recruited for this prospective study. The women’s retinal vascular status was measured by OCTA at 3 time points: the early follicular, ovulatory, and midluteal phases of the menstrual cycle. The main outcome measures were foveal avascular zone (FAZ) parameters, perfusion density (PD) percentage in the superficial retinal capillary plexus (SCP), and PD percentage in the deep retinal capillary plexus (DCP). The mean arterial pressure (MAP), spherical equivalent (SE), best-corrected visual acuity (BCVA), intraocular pressure (IOP), and axial (AL) were also measured in a same menstrual cycle. Results. In total, 62 right eyes of 62 women were included in the study. The mean age was 27.0 ± 1.73 (range, 24 to 31) years, and the mean menstrual cycle was 28.90 ± 0.84 (range, 28 to 30) days. The mean values of the DCP-PD parameters were significantly decreased in the nasal and inferior ETDRS subfields during the ovulatory phase. The mean DCP-PD in the nasal ETDRS subfield in the early follicular, ovulatory, and luteal phases was 54.11 ± 2.85, 56.39 ± 3.03, and 55.70 ± 3.27, respectively. The mean DCP-PD in the inferior ETDRS subfield in the early follicular, ovulatory, and midluteal phases was 52.90 ± 3.30, 54.86 ± 2.51, and 55.21 ± 2.64, respectively. No significant differences were found in MAP, SE, AL, IOP, FAZ area, or other quadrants of PD parameters, and no significant correlation was found between parameters by OCTA and age, MAP,SE, axial length, or IOP. Conclusions. The DCP-PD decreased in the nasal and inferior ETDRS subfields during the ovulatory phase in our study. This may indicate the need to consider the menstrual phase when interpreting DCP-PD parameters by OCTA in healthy women.

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An automated framework to quantify areas of regional ischemia in retinal vascular diseases with OCT angiography

Cited by 10 publications

References 23 publications

Biomarkers of Peripheral Nonperfusion in Retinal Venous Occlusions Using Optical Coherence Tomography Angiography

Biomarkers of Peripheral Nonperfusion in Retinal Venous Occlusions Using Optical Coherence Tomography Angiography

Retinal Vascular Changes During Pregnancy Detected With Optical Coherence Tomography Angiography

Retinal Vascular Changes during the Menstrual Cycle Detected with Optical Coherence Tomography Angiography

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