Introduction: Accurately filling out death certificates is essential for death surveillance. However, manually determining the underlying cause of death is often imprecise. In this study, we investigate the Wide and Deep framework as a method to improve the accuracy and reliability of inferring the underlying cause of death.Methods: Death report data from national-level cause of death surveillance sites in Fujian Province from 2016 to 2022, involving 403,547 deaths, were analyzed. The Wide and Deep embedded with Convolutional Neural Networks (CNN) was developed. Model performance was assessed using weighted accuracy, weighted precision, weighted recall, and weighted area under the curve (AUC). A comparison was made with XGBoost, CNN, Gated Recurrent Unit (GRU), Transformer, and GRU with Attention.Results: The Wide and Deep achieved strong performance metrics on the test set: precision of 95.75%, recall of 92.08%, F1 Score of 93.78%, and an AUC of 95.99%. The model also displayed specific F1 Scores for different cause-of-death chain lengths: 97.13% for single causes, 95.08% for double causes, 91.24% for triple causes, and 79.50% for quadruple causes.Conclusions: The Wide and Deep significantly enhances the ability to determine the root causes of death, providing a valuable tool for improving causeof-death surveillance quality. Integrating artificial intelligence (AI) in this field is anticipated to streamline death registration and reporting procedures, thereby boosting the precision of public health data.