“…The great need for automated methods has led to the development of a wide variety of segmentation methods [4], among which thresholding [5], pixel classification [6][7][8], deformable models. This latter family of methods have been greatly used thanks to their flexibility, especially for this application [9][10][11][12], either on the form of 2D active contours or 3D deformable surfaces, which are more computationally expensive [13,14]. Shape prior information can also be used to guide the segmentation process, under the form of a statistical model, in a variational framework [15], by using active shape and appearance [16][17][18][19][20] or via an atlas, using registration-based segmentation [21,22].…”