An automated synthesis of N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) for imaging serotonin transporters

Peng, Chi-Jiun; Huang, Ya-Yao; Huang, Wen-Sheng; Shiue, Chyng‐Yann

doi:10.1016/j.apradiso.2007.11.009

Cited by 29 publications

(16 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 4-[ 18 F]-ADAM used in the present study was synthesized in an automated synthesizer as previously described ( Peng et al, 2008 ). The preparations for 4-[ 18 F]-ADAM synthesis were carried out in our PET cGMP laboratory and were inspected by the Council of Atomic Energy and the Department of Health of Taiwan.…”

Section: Methodsmentioning

confidence: 99%

Incongruent Reduction of Serotonin Transporter Associated with Suicide Attempts in Patients with Major Depressive Disorder: A Positron Emission Tomography Study with 4-[18F]-ADAM

Yeh

Chen

et al. 2015

International Journal of Neuropsychopharmacology

Self Cite

View full text Add to dashboard Cite

Background:Much evidence supports the role of the serotonin transporter (SERT) in the pathophysiology and pharmacotherapy of major depressive disorder (MDD) and suicidal behaviors.Methods:In this study, we recruited 17 antidepressant-naïve patients with MDD and 17 age- and gender-matched healthy controls. SERT availability was measured in vivo with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) positron emission tomography (PET) imaging. The 21-item Hamilton Depression Rating Scale (HDRS) and Beck Scale for Suicide Ideation were used to assess the severity of depression and the intent of suicide ideation prior to PET imaging. All subjects with MDD were in a current state of depression with HDRS scores ≧18. Subjects who attempted suicide within two weeks of the study onset were recruited in the depressed suicidal group (n = 8). Subjects with MDD who denied any prior suicide attempt were recruited into the depressed non-suicidal group (n = 9).Results:A significant reduction of SERT availability in the midbrain, thalamus, and striatum was noted in the MDD group relative to the control group (Bonferroni-adjusted p-value < 0.05). Moreover, this effect was more pronounced in the depressed suicidal group compared to the control group (Bonferroni-adjusted p-value < 0.01). Relative to both the depressed non-suicidal and control groups, the depressed suicidal group showed an increased prefrontal cortex (PFC)/midbrain SERT binding ratio (Bonferroni-adjusted p-value < 0.01).Conclusions:This study suggests an incongruent reduction of PFC SERT binding relative to the midbrain might discriminate between depressed suicide attempters and non-attempters in patients with MDD and may be involved in the pathophysiology of suicide behaviors.

show abstract

Section: Methodsmentioning

confidence: 99%

Incongruent Reduction of Serotonin Transporter Associated with Suicide Attempts in Patients with Major Depressive Disorder: A Positron Emission Tomography Study with 4-[18F]-ADAM

Yeh

Chen

et al. 2015

International Journal of Neuropsychopharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…PET procedure 4-[ 18 F]-aDaM was synthesized in an automated synthesizer, as described previously (Peng et al 2008). all 20 subjects underwent a low-dose CT scan (130 kVp, 50 mas) and then a static imaging in three-dimensional mode at 120 min after an intra-World J Biol Psychiatry Downloaded from informahealthcare.com by Emory University on 07/29/15…”

Section: Psychological Measures Of Depression and Suicide Ideationmentioning

confidence: 99%

Suicidal ideation modulates the reduction in serotonin transporter availability in male military conscripts with major depression: A 4-[¹⁸F]-ADAM PET study

Yeh

Chen

et al. 2015

The World Journal of Biological Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…The 18 F-labelled form of ADAM, 4-[ 18 F]ADAM (N,N-dimethyl-2-(2-amino-4-[ 18 F]fluorophenylthio)benzylamine) has been synthesized and a synthesis methodology suitable for PET imaging has been reported. 398,399 With microPET and autoradiography, [ 18 F]ADAM has a rapid brain uptake and high target-to-background ratios and the specific signal was displaceable by paroxetine. 400 Further studies in rat and monkey PET confirmed that biodistribution, dosimetry, and toxicity data support its investigation in human subjects.…”

Section: [ 18 F]adammentioning

confidence: 99%

5‐HT radioligands for human brain imaging with PET and SPECT

Paterson

Kornum

Nutt

et al. 2011

Medicinal Research Reviews

145

129

View full text Add to dashboard Cite

The serotonergic system plays a key modulatory role in the brain and is the target for many drug treatments for brain disorders either through reuptake blockade or via interactions at the 14 subtypes of 5-HT receptors. This review provides the history and current status of radioligands used for positron emission tomography (PET) and single photon emission computerized tomography (SPECT) imaging of human brain serotonin (5-HT) receptors, the 5-HT transporter (SERT), and 5-HT synthesis rate. Currently available radioligands for in vivo brain imaging of the 5-HT system in humans include antagonists for the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4 receptors, and for SERT. Here we describe the evolution of these radioligands, along with the attempts made to develop radioligands for additional serotonergic targets. We describe the properties needed for a radioligand to become successful and the main caveats. The success of a PET or SPECT radioligand can ultimately be assessed by its frequency of use, its utility in humans, and the number of research sites using it relative to its invention date, and so these aspects are also covered. In conclusion, the development of PET and SPECT radioligands to image serotonergic targets is of high interest, and successful evaluation in humans is leading to invaluable insight into normal and abnormal brain function, emphasizing the need for continued development of both SPECT and PET radioligands for human brain imaging.

show abstract

An automated synthesis of N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) for imaging serotonin transporters

Cited by 29 publications

References 14 publications

Incongruent Reduction of Serotonin Transporter Associated with Suicide Attempts in Patients with Major Depressive Disorder: A Positron Emission Tomography Study with 4-[18F]-ADAM

Incongruent Reduction of Serotonin Transporter Associated with Suicide Attempts in Patients with Major Depressive Disorder: A Positron Emission Tomography Study with 4-[18F]-ADAM

Suicidal ideation modulates the reduction in serotonin transporter availability in male military conscripts with major depression: A 4-[¹⁸F]-ADAM PET study

5‐HT radioligands for human brain imaging with PET and SPECT

Contact Info

Product

Resources

About

An automated synthesis of N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) for imaging serotonin transporters

Cited by 29 publications

References 14 publications

Incongruent Reduction of Serotonin Transporter Associated with Suicide Attempts in Patients with Major Depressive Disorder: A Positron Emission Tomography Study with 4-[18F]-ADAM

Incongruent Reduction of Serotonin Transporter Associated with Suicide Attempts in Patients with Major Depressive Disorder: A Positron Emission Tomography Study with 4-[18F]-ADAM

Suicidal ideation modulates the reduction in serotonin transporter availability in male military conscripts with major depression: A 4-[18F]-ADAM PET study

5‐HT radioligands for human brain imaging with PET and SPECT

Contact Info

Product

Resources

About

Suicidal ideation modulates the reduction in serotonin transporter availability in male military conscripts with major depression: A 4-[¹⁸F]-ADAM PET study