An automatic framework for quantitative validation of voxel based morphometry measures of anatomical brain asymmetry

Pepe, Antonietta; Dinov, Ivo D.; Tohka, Jussi

doi:10.1016/j.neuroimage.2014.06.029

Cited by 13 publications

(17 citation statements)

References 54 publications

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“…They can be used, for example, as priors during tissue segmentation or to mask functional MRI analysis to only gray matter. Haiko89 is also accompanied with the first symmetric baboon brain template (Haiko89_Sym), which provides researchers with the means to conduct voxel-based brain lateralization research in the baboon that is free from the confound created by normalizing to an asymmetric template (Fonov et al, 2011;Pepe et al, 2014). Furthermore, Haiko89 is the only available skull stripped baboon brain template that includes the olfactory bulb.…”

Section: Discussionmentioning

confidence: 99%

“…For both human and non-human primate brains, it is well known that there are differences in morphology across the two cerebral hemispheres (e.g., Barrick et al, 2005;Pilcher et al, 2001). Symmetric templates are critical when investigating these hemispheric differences using, for example, voxel-based morphometry (VBM, Ashburner and Friston, 2000); normalization to an asymmetric template introduces a confound as it is impossible to conclude whether hemispheric differences are real or simply caused by normalization to an asymmetric template (Fonov et al, 2011;Pepe et al, 2014). Fourth, to our knowledge there are no tissue probability maps available to aid in the normalization or the segmentation of baboon brains.…”

Section: Introductionmentioning

confidence: 99%

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The average baboon brain: MRI templates and tissue probability maps from 89 individuals

et al. 2016

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The baboon (Papio) brain is a remarkable model for investigating the brain. The current work aimed at creating a population-average baboon (Papio anubis) brain template and its left/right hemisphere symmetric version from a large sample of T1-weighted magnetic resonance images collected from 89 individuals. Averaging the prior probability maps output during the segmentation of each individual also produced the first baboon brain tissue probability maps for gray matter, white matter and cerebrospinal fluid. The templates and the tissue probability maps were created using state-of-the-art, freely available software tools and are being made freely and publicly available: http://www.nitrc.org/projects/haiko89/ or http://lpc.univ-amu.fr/spip.php?article589. It is hoped that these images will aid neuroimaging research of the baboon by, for example, providing a modern, high quality normalization target and accompanying standardized coordinate system as well as probabilistic priors that can be used during tissue segmentation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The average baboon brain: MRI templates and tissue probability maps from 89 individuals

et al. 2016

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“…Figure 1 and Figure 5A illustrate a potential laterality effect on GM rate of atrophy that was not investigated in the present study since the methodological design used here did not allow us to statistically test for differences between the left and right hemispheres. Indeed, the 3C-MRI template used for spatial normalization was not a symmetrical one, and use of asymmetrical templates for both spatial normalization and segmentation is known to introduce biases in the study of hemispheric anatomical features [63] . Moreover the AAL parcellation used to estimate the regional GM rate of atrophy is also asymmetric.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Assessment of Global and Regional Rate of Grey Matter Atrophy in 1,172 Healthy Older Adults: Modulation by Sex and Age

et al. 2014

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To characterize the neuroanatomical changes in healthy older adults is important to differentiate pathological from normal brain structural aging. The present study investigated the annualized rate of GM atrophy in a large sample of older participants, focusing on the hippocampus, and searching for modulation by age and sex. In this 4-year longitudinal community cohort study, we used a VBM analysis to estimate the annualized rate of GM loss, at both the global and regional levels, in 1,172 healthy older adults (65–82 years) scanned at 1.5T. The global annualized rate of GM was −4.0 cm3/year (−0.83%/year). The highest rates of regional GM loss were found in the frontal and parietal cortices, middle occipital gyri, temporal cortex and hippocampus. The rate of GM atrophy was higher in women (−4.7 cm3/year, −0.91%/year) than men (−3.3 cm3/year, −0.65%/year). The global annualized rate of GM atrophy remained constant throughout the age range of the cohort, in both sexes. This pattern was replicated at the regional level, with the exception of the hippocampi, which showed a rate of GM atrophy that accelerated with age (2.8%/year per year of age) similarly for men and women. The present study reports a global and regional description of the annualized rate of grey matter loss and its evolution after the age of 65. Our results suggest greater anatomical vulnerability of women in late life and highlight a specific vulnerability of the hippocampus to the aging processes after 65 years of age.

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“…Using deformation parameters calculated by the DARTEL toolbox, the gray matter images were normalized to MNI space and smoothed with a Gaussian kernel (FWHM = 8 mm). We set FWHM at 8 mm because the value was widely used (for review, see Nickl-Jockschat et al, 2012) and previous studies demonstrated that this size of spatial smoothing would improve the accuracy of VBM (Pepe et al, 2014) without increasing false-positive rates (Scarpazza et al, 2015). This preprocessing using DARTEL Toolbox included a modulation process to preserve the volume of a particular tissue within a voxel (Good et al, 2001).…”

Section: Methodsmentioning

confidence: 99%

A Neuroanatomical Substrate Linking Perceptual Stability to Cognitive Rigidity in Autism

et al. 2019

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Overly stable visual perception seen in individuals with autism spectrum disorder (ASD) is related to higher-order core symptoms of the condition. However, the neural basis by which these seemingly different symptoms are simultaneously observed in individuals with ASD remains unclear. Here, we aimed to identify such a neuroanatomical substrate linking perceptual stability to autistic cognitive rigidity, a part of core restricted, repetitive behaviors (RRBs). First, using a bistable visual perception test, we measured the perceptual stability of 22 high-functioning adults with ASD and 22 age-, IQ-, and sex-matched typically developing human individuals and confirmed overstable visual perception in autism. Next, using a spontaneous task-switching (TS) test, we showed that the individuals with ASD were more likely to repeat the same task voluntarily and spontaneously, and such rigid TS behavior was associated with the severity of their RRB symptoms. We then compared these perceptual and cognitive behaviors and found a significant correlation between them for individuals with ASD. Finally, we found that this behavioral link was supported by a smaller gray matter volume (GMV) of the posterior superior parietal lobule (pSPL) in individuals with ASD. Moreover, this smaller GMV in the pSPL was also associated with the RRB symptoms and replicated in two independent datasets. Our findings suggest that the pSPL could be one of the neuroanatomical mediators of cognitive and perceptual inflexibility in autism, which could help a unified biological understanding of the mechanisms underpinning diverse symptoms of this developmental disorder. SIGNIFICANCE STATEMENT Behavioral studies show perceptual overstability in autism spectrum disorder (ASD). However, the neural mechanisms by which such sensory symptoms can coexist and often correlate with seemingly separate core symptoms remain unknown. Here, we have identified such a key neuroanatomical substrate. We have revealed that overstable sensory perception of individuals with ASD is linked with their cognitive rigidity, a part of core restricted, repetitive behavior symptoms, and such a behavioral link is underpinned by a smaller gray matter volume in the posterior superior parietal lobule in autism. These findings uncover a key neuroanatomical mediator of autistic perceptual and cognitive inflexibility and would ignite future studies on how the core symptoms of ASD interact with its unique sensory perception.

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An automatic framework for quantitative validation of voxel based morphometry measures of anatomical brain asymmetry

Cited by 13 publications

References 54 publications

The average baboon brain: MRI templates and tissue probability maps from 89 individuals

The average baboon brain: MRI templates and tissue probability maps from 89 individuals

Longitudinal Assessment of Global and Regional Rate of Grey Matter Atrophy in 1,172 Healthy Older Adults: Modulation by Sex and Age

A Neuroanatomical Substrate Linking Perceptual Stability to Cognitive Rigidity in Autism

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