An automatic method for quantification of myocardium at risk from myocardial perfusion SPECT in patients with acute coronary occlusion

Soneson, Helen; Engblom, Henrik; Hedström, Erik; Bouvier, Frédéric; Sörensson, Peder; Pernow, John; Arheden, Håkan; Heiberg, Einar

doi:10.1007/s12350-010-9237-z

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…Analysis of myocardial perfusion SPECT defect for MaR was performed off-line using freely available segmentation software (Segment v1.702; http://segment.heiberg.se)[26,27]. The automatic segmentation finds the centerline through the left ventricular wall and identifies the endo- and epicardium based on an individually estimated wall thickness and signal intensity values within the image [28].…”

Section: Methodsmentioning

confidence: 99%

Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography

Sörensson

Heiberg

Saleh

et al. 2010

Journal of Cardiovascular Magnetic Resonance

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BackgroundFinal infarct size following coronary occlusion is determined by the duration of ischemia, the size of myocardium at risk (MaR) and reperfusion injury. The reference method for determining MaR, single-photon emission computed tomography (SPECT) before reperfusion, is impractical in an acute setting. The aim of the present study was to evaluate whether MaR can be determined from the contrast enhanced myocardium using steady-state free precession (SSFP) cine cardiovascular magnetic resonance (CMR) performed one week after the acute event in ST-elevation myocardial infarction (STEMI) patients with total coronary occlusion.ResultsSixteen patients with STEMI (age 64 ± 8 years) received intravenous 99 m-Tc immediately before primary percutaneous coronary intervention. SPECT was performed within four hours. MaR was defined as the non-perfused myocardial volume derived with SPECT. CMR was performed 7.8 ± 1.2 days after the myocardial infarction using a protocol in which the contrast agent was administered before acquisition of short-axis SSFP cines. MaR was evaluated as the contrast enhanced myocardial volume in the cines by two blinded observers. MaR determined from the enhanced region on cine CMR correlated significantly with that derived with SPECT (r2 = 0.78, p < 0.001). The difference in MaR determined by CMR and SPECT was 0.5 ± 5.1% (mean ± SD). The interobserver variability of contrast enhanced cine SSFP measurements was 1.6 ± 3.7% (mean ± SD) of the left ventricle wall volume.ConclusionsContrast enhanced SSFP cine CMR performed one week after acute infarction accurately depicts MaR prior to reperfusion in STEMI patients with total occlusion undergoing primary PCI. This suggests that a single CMR examination might be performed for determination of MaR and infarct size.

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Section: Methodsmentioning

confidence: 99%

Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography

Sörensson

Heiberg

Saleh

et al. 2010

Journal of Cardiovascular Magnetic Resonance

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“…There have been a lot of diagnostic devices to detect ACO in medicine. Non-invasive imaging modalities such as perfusion computed tomography (perfusion CT) and single-photon emission computed tomography (SPECT) are the examples [23]. In addition, the body surface potential map (BSPM) is used to examine ischemic heart.…”

Section: Introductionmentioning

confidence: 99%

“…In many cases, these methods can measure the infarcted myocardial region of the heart and provide reference data for the treatment of patient [3]. Most cases of ACO are induced by plaque rupture or erosion, showing active collateral vessels due to plaque progression [67].…”

Section: Introductionmentioning

confidence: 99%

In silico evaluation of the acute occlusion effect of coronary artery on cardiac electrophysiology and the body surface potential map

Ryu

Lee

Kwon

et al. 2019

Korean J Physiol Pharmacol

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Body surface potential map, an electric potential distribution on the body torso surface, enables us to infer the electrical activities of the heart. Therefore, observing electric potential projected to the torso surface can be highly useful for diagnosing heart diseases such as coronary occlusion. The BSPM for the heart of a patient show a higher level of sensitivity than 12-lead ECG. Relevant research has been mostly based on clinical statistics obtained from patients, and, therefore, a simulation for a variety of pathological phenomena of the heart is required. In this study, by using computer simulation, a body surface potential map was implemented according to various occlusion locations (distal, mid, proximal occlusion) in the left anterior descending coronary artery. Electrophysiological characteristics of the body surface during the ST segment period were observed and analyzed based on an ST isointegral map. We developed an integrated system that takes into account the cellular to organ levels, and performed simulation regarding the electrophysiological phenomena of the heart that occur during the first 5 minutes (stage 1) and 10 minutes (stage 2) after commencement of coronary occlusion. Subsequently, we calculated the bipolar angle and amplitude of the ST isointegral map, and observed the correlation between the relevant characteristics and the location of coronary occlusion. In the result, in the ventricle model during the stage 1, a wider area of ischemia led to counterclockwise rotation of the bipolar angle; and, during the stage 2, the amplitude increased when the ischemia area exceeded a certain size.

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Impact of scar on SPECT assay of left ventricular contraction dyssynchrony

Ludwig

Friehling

Schelbert

et al. 2013

Eur J Nucl Med Mol Imaging

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An automatic method for quantification of myocardium at risk from myocardial perfusion SPECT in patients with acute coronary occlusion

Abstract: Background: In order to determine myocardial salvage, accurate quantification of

Cited by 9 publications

References 23 publications

Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography

Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography

In silico evaluation of the acute occlusion effect of coronary artery on cardiac electrophysiology and the body surface potential map

Impact of scar on SPECT assay of left ventricular contraction dyssynchrony

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