An autonomous microbial sensor enables long-term detection of TNT explosive in natural soil
Erin A. Essington,
Grace E. Vezeau,
Daniel P. Cetnar
et al.
Abstract:Microbes can be engineered to sense target chemicals for environmental and geospatial detection. However, when engineered microbes operate in real-world environments, it remains unclear how competition with natural microbes affect their performance over long time periods. Here, we engineer sensors and memory-storing genetic circuits inside the soil bacterium
Bacillus subtilis
to sense the TNT explosive and maintain a long-term response, using predictive models to design riboswitch sensor… Show more
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