An autopsy case of acute selenium (selenious acid) poisoning and selenium levels in human tissues

Matoba, Ryoji; Kimurâ, Hiroshi; Uchima, Eikoh; Abe, Takashi; Yamada, Tadashi; Mitsukuni, Yoichi; Shikata, Ichiro

doi:10.1016/0379-0738(86)90192-1

Cited by 26 publications

(12 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other organs, it exceeded physiological levels by 10-20 times with the relatively lowest value in lung tissue. The selenium concentration in blood was about 10 times higher than the normal selenium level in the blood of healthy people (10,(32)(33)(34)(35).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Application of Three Spectrometric Methods to Total Selenium Determination in Postmortem Material in a Case of Acute Selenium Compound Poisoning

Wietecha‐Posłuszny

Lech

Kościelniak

2011

Journal of Forensic Sciences

View full text Add to dashboard Cite

Three spectrometric methods, that is, spectrofluorimetry (SF), atomic absorption spectrometry with electrothermal atomization (ET-AAS), and atomic fluorescence spectrometry with hydride generation (HG-AFS) were used for the determination of total selenium in biological samples taken from postmortem material in a case of acute selenium compound poisoning. The precision of the SF, ET-AAS, and HG-AFS methods (RSD, n=10) was found to be in the ranges of 10.0-15.0, 3.0-6.0 and 1.0-1.5%, respectively, and the detection limit was 10.0, 4.0, and 0.1 μg/L of Se, respectively. In the case of HG-AFS, the analytical procedure takes less time and is less laborious than the other methods considered. The obtained results show the usefulness of the HG-AFS method as a supplementary analytical tool to the SF and ET-AAS methods with respect to the determination of selenium as well as the possibility of using this method as a primary one in forensic toxicology practice.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Acute selenium toxicity has been observed in experimental animals (7). Reports of acute selenium poisoning in humans are rare (5,(8)(9)(10); only about 20 cases were reported until 2008 (11).…”

mentioning

confidence: 99%

Application of Three Spectrometric Methods to Total Selenium Determination in Postmortem Material in a Case of Acute Selenium Compound Poisoning

Wietecha‐Posłuszny

Lech

Kościelniak

2011

Journal of Forensic Sciences

View full text Add to dashboard Cite

show abstract

“…We characterized the inflammatory response of the respiratory airways of the mouse after intratracheal instillation of dimethyl selenide (DMSe). Most of the studies on the toxicology of selenium (Se) have used oral ingestion (Nantel et al, 1985;Pentel et al, 1985;Köppel et al, 1986;Matoba et al, 1986;Gasmi et al, 1997). Only a few investigations have documented that Se inhalation is harmful for the airways and lungs (Bell et al, 1997a(Bell et al, , 1997b(Bell et al, , 1998Nonavinakere et al, 1999;Cherdwongcharoensuk et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Changes in Bronchoalveolar Lavage Cells after Intratracheal Instillation of Dimethyl Selenide in Mice

Cherdwongcharoensuk

Upatham

Oliveira³

et al. 2004

Toxicol Pathol

View full text Add to dashboard Cite

CD-1 mice were exposed to a single intratracheal instillation of either 0.025 or 0.075 mg Se/kg wt of dimethyl selenide (DMSe). They were studied over 4 weeks to define the cellular inflammatory response of the airways to DMSe. Bronchoalveolar (BAL) lavage was used to collect the DMSe-induced inflammatory exudates. The DMSe instillation resulted in phlogistic responses that had the neutrophil as the main leukocyte; they were present in BAL samples, mostly at days 1 and 7. Macrophages were also increased during DMSe-induced inflammation. The lower DMSe dose resulted in an inflammatory reaction lasting for 2 weeks. Mice treated with the higher DMSe dose still showed elevated numbers of neutrophils and macrophages 4 weeks after instillation. DMSe did not change the number of lymphocytes harvested from the airways. An early increase in total protein of BAL, and late enhancement in lactate dehydrogenase was observed in mice treated with the high DMSe dose. We conclude that inhalation of DMSe triggers a moderate and dose-dependent inflammatory reaction in the mouse airways, and that this phlogistic reaction is likely to participate in the damage of respiratory epithelia that occurs upon DMSe inhalation.

show abstract

“…Conversely, acute selenium toxicity has been observed in experimental animals [37], and several reports of acute selenium poisoning in humans have also been described [31,[38][39][40][41][42][43].…”

Section: Seleniummentioning

confidence: 99%

Untitled

2020

Int J Exp Spectroscopic Tech

View full text Add to dashboard Cite

In this short review, a reliability of electrothermal atomic absorption spectrometry (ETAAS) for the quantification of trace selenium in blood serum is described and discussed. The main attention is given to the measurement conditions, especially those of pyrolysis temperature, in order to avoid possible pre-atomization loss of selenium; and spectral interferences that can be expected to be encountered when analyzing blood serum. Optimization of both the measurement conditions and the operating instrumental conditions facilitates the achievement of reliable results.

show abstract

An autopsy case of acute selenium (selenious acid) poisoning and selenium levels in human tissues

Cited by 26 publications

References 9 publications

Application of Three Spectrometric Methods to Total Selenium Determination in Postmortem Material in a Case of Acute Selenium Compound Poisoning

Application of Three Spectrometric Methods to Total Selenium Determination in Postmortem Material in a Case of Acute Selenium Compound Poisoning

Changes in Bronchoalveolar Lavage Cells after Intratracheal Instillation of Dimethyl Selenide in Mice

Untitled

Contact Info

Product

Resources

About