An Autopsy Case of An Acute Exacerbation of Idiopathic Pulmonary Fibrosis Triggered by the Inhalation of a Waterproofing Spray

Kawaguchi, Takako; Terauchi, Takashi; Yamasaki, Kei; Nakamura, Kei; Katafuchi, Eisuke; Tahara, Masahiro; Isoshima, Yu; Ohira, Hidenori; Kawabata, Hiroki; Hara, Kanako; Yatera, Kazuhiro

doi:10.2169/internalmedicine.8330-21

Cited by 3 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with chemical pneumonitis due to the inhalation of products other than waterproofing sprays were excluded, and the articles that did not report the duration of improvement and laboratory data were excluded. The age, sex, pack-years, chief complaints, radiological findings, use of steroid treatment (or not), and duration of WALI improvement were investigated [ 2 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ].…”

Section: Methodsmentioning

confidence: 99%

Waterproofing Spray-Associated Lung Injury Review: Differences between Cases of Early and Delayed Improvement of Waterproofing Spray-Associated Lung Injury

Kodaka

Nakano

Oshio

et al. 2023

JCM

View full text Add to dashboard Cite

Waterproofing spray-associated lung injury (WALI) is an acute respiratory disorder characterized by bilateral diffuse lung injury on chest computed tomography (CT). In most cases, the symptoms and abnormal radiographic findings of WALI patients improve spontaneously over several days; however, some cases have persistent symptoms and abnormal shadows for >1 week. The distinctive features of each WALI are unknown. Herein, we present two new cases of WALI that we encountered in our hospital, and we previously reported two other cases of WALI. We examined the characteristics of WALI in our cases and 39 other cases of WALI definitively diagnosed and reported in PubMed and the Japan medical board with verifiable data during a 15-year period. We compared the clinical characteristics of the 22 cases in which the patients’ symptoms were resolved within 1 week (early improvement) to those of the 21 cases in which the symptoms were resolved after >1 week (delayed improvement). The WALI cases with delayed improvement had significantly more shadowing that extended over the entire lung field and was not biased in intensity toward the upper or lower lung field. In addition, the serum white blood cell (WBC) counts and serum Krebs von den Lungen-6 (KL-6) levels differed significantly between the cases of early and delayed improvement of WALI.

show abstract

Section: Methodsmentioning

confidence: 99%

Waterproofing Spray-Associated Lung Injury Review: Differences between Cases of Early and Delayed Improvement of Waterproofing Spray-Associated Lung Injury

Kodaka

Nakano

Oshio

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…Symptoms often appear during or shortly after spray application. The symptoms resolve after a few days, but sometimes have long lasting effects on the lungs, usually when there is an underlying pathology of the lungs (e.g., [ 3 , 9 , 10 ]).…”

Section: Introductionmentioning

confidence: 99%

The Underlying Mechanism of Poisoning after the Accidental Inhalation of Aerosolised Waterproofing Spray

Jensen,

Ebbehøj,

Huusom

et al. 2024

JoX

View full text Add to dashboard Cite

Waterproofing sprays can cause acute respiratory symptoms after inhalation, including coughing and dyspnoea shortly after use. Here, we describe two cases where persons used the same brand of waterproofing spray product. In both cases the persons followed the instructions on the product and maximized the ventilation by opening windows and doors; however, they still became affected during the application of the product. Products with the same batch number as that used in one case were tested for their effect on respiration patterns of mice in whole-body plethysmographs and lung surfactant function inhibition in vitro. The product was used in spraying experiments to determine the particle size distribution of the aerosol, both using a can from one case and a can with an identical batch number. In addition, the aerosols in the mouse exposure chamber were measured. Aerosol data from a small-scale exposure chamber and data on the physical and temporal dimensions of the spraying during one case were used to estimate the deposited dose during the spraying events. All collected data point to the spraying of the waterproofing product being the reason that two people became ill, and that the inhibition of lung surfactant function was a key component of this illness.

show abstract

Ciclosporin/methylprednisolone/prednisolone

2022

Reactions Weekly

View full text Add to dashboard Cite

An Autopsy Case of An Acute Exacerbation of Idiopathic Pulmonary Fibrosis Triggered by the Inhalation of a Waterproofing Spray

Cited by 3 publications

References 14 publications

Waterproofing Spray-Associated Lung Injury Review: Differences between Cases of Early and Delayed Improvement of Waterproofing Spray-Associated Lung Injury

Waterproofing Spray-Associated Lung Injury Review: Differences between Cases of Early and Delayed Improvement of Waterproofing Spray-Associated Lung Injury

The Underlying Mechanism of Poisoning after the Accidental Inhalation of Aerosolised Waterproofing Spray

Ciclosporin/methylprednisolone/prednisolone

Contact Info

Product

Resources

About