An autopsy case of hepatocellular carcinoma producing granulocyte colony-stimulating factor.

Hori, Shinichiro; Takebayashi, J; Okamoto, Tomoko; Setsu, Koujun; Senoh, Tomonori

doi:10.2957/kanzo.39.401

Cited by 7 publications

(6 citation statements)

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“…[8][9][10][11][12][13][14][15][16][17][18][19][20] However, patients with HCC rarely have marked granulocytosis with the production of G-CSF in HCC. 8,21,22 We present a case of HCC that showed marked granulocytosis and elevated serum G-CSF detected by enzyme-linked immunosorbent assay (ELISA) and immunohistochemical staining of intracytoplasmic G-CSF in HCC cells, confirming that this HCC was a G-CSF-producing tumor.…”

Section: Introductionmentioning

confidence: 65%

“…1,2,[8][9][10][11][12][13][14][15][16] However, in patients with HCC, only a few cases have been reported to be associated with granulocytosis. 8,21,22 One case of HCC associated with granulocytosis and positive immunostaining of G-CSF at autopsy was reported by Hori et al 21 In this case, HCC was the moderately differentiated type. Some hepatoma-derived cell lines may express and produce bioactive G-CSF in vitro.…”

Section: Discussionmentioning

confidence: 80%

“…8,9,14,25 Lung cancer is known to produce such cytokines, but HCC rarely produces several cytokines. [11][12][13][14][15][16][21][22][23][24][25][26][27] Various degrees of granulocytosis in patients with malignant tumors, especially lung cancer, have been previously reported. 1,2,[8][9][10][11][12][13][14][15][16] However, in patients with HCC, only a few cases have been reported to be associated with granulocytosis.…”

Section: Discussionmentioning

confidence: 99%

“…However, in another case of HCC with granulocytosis and positive immunostaining of G-CSF reported by Hori et al, HCC was the moderately differentiated type. 21 Therefore, the relationship between the differentiation grade of HCC and the development of G-CSF-producing ability remains to be elucidated. Previous studies showed that liver expression of G-CSF was augmented in mice challenged by inflammatory stimuli.…”

Section: Case Reportmentioning

confidence: 99%

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Granulocyte-colony-stimulating-factor-producing hepatocellular carcinoma

Yamamoto

Takashima

Ogawa

et al. 1999

Journal of Gastroenterology

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Patients with hepatocellular carcinoma (HCC) rarely show marked granulocytosis. We report an interesting case of rapidly growing poorly differentiated HCC associated with marked granulocytosis. The blood leukocyte count decreased following several treatments for HCC, including transcatheter arterial embolization, and increased again along with tumor regrowth. The serum levels of granulocyte colony-stimulating factor (G-CSF) were markedly elevated, and immunohistochemical study showed G-CSF staining in the cytoplasm of certain HCC cells. These findings confirm that HCC in this case was a G-CSF-producing tumor.

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Section: Introductionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

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Granulocyte-colony-stimulating-factor-producing hepatocellular carcinoma

Yamamoto

Takashima

Ogawa

et al. 1999

Journal of Gastroenterology

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“…As is common knowledge, HCC usually occurs in patients with liver cirrhosis and chronic hepatitis caused by hepatitis B or C virus infection. Only a few cases of HCC have ever been reported to show G‐CSF production by tumour cells (11–14). In the G‐CSF‐producing HCC case reported here, a radical resection was performed; as a result, the patient's prognosis was similar to that in typical cases.…”

mentioning

confidence: 99%

Hepatocellular carcinoma producing a granulocyte colony‐stimulating factor: report of a resected case with a literature review

Araki

Kishihara

Takahashi

et al. 2007

Liver International

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A complete resection of a hepatocellular carcinoma (HCC) producing the granulocyte colony-stimulating factor (G-CSF) was performed and is reported here. The patient had a few general symptoms and complications, such as the paraneoplastic syndrome. He had marked granulocytosis, and his serum levels of G-CSF and interleukin-6 were elevated. The pathological findings of the resected specimen revealed poorly differentiated HCC with sarcomatous change and showed, immunohistochemically, staining of G-CSF. Only a few cases of G-CSF-producing HCC have been reported, and they resulted in rapid tumour growth and poor prognosis. The case presented here may be the first complete resection ever performed, but the patient's prognosis was similar to that observed in typical cases.

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