An autopsy case of ruptured liver metastases from small cell lung cancer: A case report and literature review

The Diagnostic Dilemma of Ruptured Liver Metastasis in a Patient with Lung Cancer

“…The commonly observed symptoms in patients with ruptured liver metastasis are non-specific abdominal pain, discomfort followed by haemodynamic instabilities, fever in case of infected collection or as a part of the systemic inflammatory response (SIRS), acute liver failure and multi-organ dysfunction syndrome. 8 In the present case, the patient presented with fever, non-specific abdominal pain, SIRS (heart rate >90 beats/min and respiratory rate >20/min) and a soft and tender mass in the right hypochondrium.…”

“…7 The mechanism of spontaneous rupture of hepatic metastasis is not clear but there are several factors reported in the literature such as tumour necrosis, vascularity, location (subcapsular) and impaired coagulation. 7,8 In the present case, the probable cause of rupture may be the subcapsular location and necrotic hepatic metastasis which may be due to the presence of portal vein thrombosis.…”

A case of ruptured ovarian metastasis of small cell lung cancer

“…Ovarian surface involvement is infrequent in metastatic ovarian cancer [ 1 ]; however, in our case, the lesion extended to the surface of the ovary, which was also considered a risk factor for rupture. For liver tumors, chemotherapy can trigger rupture due to tumor necrosis [ 20 ]; however, since no chemotherapy was administered prior to rupture in our case, rapid enlargement was the likely cause.…”

Rupture of liver metastasis in high‐volume metastatic prostate cancer patient on androgen deprivation therapy combined with upfront docetaxel chemotherapy

“…7,15 The risk factors of hepatic metastasis rupture include necrotic tendency, a subcapsular location, and a rapid tumor growth. 16,17 Moreover, tumor necrosis resulting from chemotherapy has also been cited as a possible risk factor for metastatic rupture. 9 We report that although chemotherapy was effective in reducing PSA levels, no significant change was observed in the size of multiple, bulky metastatic hepatic tumors.…”

“…The risk factors of hepatic metastasis rupture include necrotic tendency, a subcapsular location, and a rapid tumor growth 16,17 . Moreover, tumor necrosis resulting from chemotherapy has also been cited as a possible risk factor for metastatic rupture 9 .…”