An Autopsy Case of Subacute Cor Pulmonale Due to Pulmonary Tumor Cell Emboli in a Patient with Gastric Cancer

Iwakami, Shin‐ichiro; Sato, Teruhiko; Takagi, Haruhi; Fujii, Mitsuhiro; Iwakami, Naoko; Yoshimi, Kaku; Koyama, Ryo; Ichikawa, Masaki; Yoshioka, Masahiro; Takahashi, Kazuhisa

doi:10.2169/internalmedicine.48.1858

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…Shortness of breath results in arterial hypoxia and respiratory alkalosis. Cough and chest pain commonly accompany PTE (47% of cases) and 15-20% of PTE patients demonstrate classic signs of pulmonary hypertension [19] likely to be associated with right heart failure (pulmonary heart disease) [17,20,21]. Except for progressive dyspnoea, the above symptoms did not contribute to the clinical presentation of the reported case.…”

Section: Discussionmentioning

confidence: 93%

The diagnostic challenge in pulmonary tumour embolism in cancer: a case report and literature review

Zielińska

Braun

Piasecka

et al. 2020

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Pulmonary tumour embolism is a rare condition without specific symptoms or pathognomonic features. Pulmonary tumour embolism can occur as the first manifestation of cancer, but because of diagnostic difficulties, it is often wrongly recognised as a more common cardiopulmonary disease. We present a case of a 46-year-old Caucasian male with no prior malignancy diagnosis, admitted because of progressing dyspnoea and cough. Based on radiological and clinical presentations, sarcoidosis, silicosis and lymphangitic carcinomatosis were considered in the differential diagnosis. Histopathological analysis of lung biopsy revealed that multiple emboli of atypical epithelial cells found in the pulmonary vessels were of gastrointestinal origin. Further pathological examination of the gastric biopsy led to the final diagnosis of the signet-ring cells gastric adenocarcinoma. The patient was referred for chemotherapy. After a short-term partial remission, he died within two months after the final diagnosis. The presented case illustrates challenges posed by the diagnostic process of pulmonary tumour embolism.

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Section: Discussionmentioning

confidence: 93%

The diagnostic challenge in pulmonary tumour embolism in cancer: a case report and literature review

Zielińska

Braun

Piasecka

et al. 2020

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“…Pulmonary tumor embolism syndrome (also known as pulmonary tumor thrombotic microangiopathy) has been reported to be found in 3% to 26% of autopsies conducted on patients with solid tumors (1)(2)(3)(4). Numerous case reports have been published (5)(6)(7)(8)(9)(10)(11)(12)(13), and in most cases the diagnosis is not made until after death. Th e incidence is highest in patients with gastric adenocarcinoma, and fewer cases have been reported with adenocarcinoma of the colon (14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%