An autopsy case report of aortic dissection complicated with histiolymphocytic pericarditis and aortic inflammation after mRNA COVID-19 vaccination

Takahashi, Motonori; Kondo, Takeshi; Yamasaki, Gentaro; Sugimoto, Masaharu; Asano, Migiwa; Ueno, Yoshio; Nagasaki, Yasushi

doi:10.1016/j.legalmed.2022.102154

Cited by 8 publications

(8 citation statements)

References 18 publications

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confidence: 99%

“…Dear Editor, we would like to share ideas on the publication “An autopsy case report of aortic dissection complicated with histiolymphocytic pericarditis and aortic inflammation after mRNA COVID-19 vaccination [1] .” An autopsy revealed pericardial hemotamponade and ascending aorta dissection, according to Takahashi et al [1] . Microscopically, the pericardium was fibrously thick and the heart displayed a white villous surface, indicating pericarditis with a predominance of macrophage and lymphocyte infiltration [1] . These histological findings were in agreement with those of post-vaccination myocarditis, according to Takahashi et al To the best of our knowledge, no cases of histopathologically confirmed pericarditis following COVID-19 vaccination have been documented, according to Takahashi et al In the present case, prolonged aortic adventitia inflammation may have contributed to the aortic wall's fragility and subsequent dissection [1] .…”

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confidence: 99%

“…Microscopically, the pericardium was fibrously thick and the heart displayed a white villous surface, indicating pericarditis with a predominance of macrophage and lymphocyte infiltration [1] . These histological findings were in agreement with those of post-vaccination myocarditis, according to Takahashi et al To the best of our knowledge, no cases of histopathologically confirmed pericarditis following COVID-19 vaccination have been documented, according to Takahashi et al In the present case, prolonged aortic adventitia inflammation may have contributed to the aortic wall's fragility and subsequent dissection [1] .…”

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An autopsy case report of aortic dissection after mRNA COVID-19 vaccination: correspondence

Mungmunpuntipantip¹,

Wiwanitkit

2023

Legal Medicine

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An autopsy case report of aortic dissection after mRNA COVID-19 vaccination: correspondence

Mungmunpuntipantip¹,

Wiwanitkit

2023

Legal Medicine

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“…We read with interest the article by Takahashi et al about an autopsy case of a >90 years old male who was found dead in his kitchen about two weeks after the third dose of the BNT162b2 (Biontech Pfizer) anti-SARS-CoV-2 vaccine [1] . Autopsy revealed that the patient had pericarditis and consecutive aortic dissection type-A [1] . Pericarditis was interpreted as causally related to the vaccination and to aortic dissection [1] .…”

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confidence: 99%

“…Autopsy revealed that the patient had pericarditis and consecutive aortic dissection type-A [1] . Pericarditis was interpreted as causally related to the vaccination and to aortic dissection [1] . The study is promising but raises concerns that should be discussed.…”

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Before blaming SARS-CoV-2 vaccination for aortic dissection, alternative causes need to be ruled out

Finsterer¹

2023

Legal Medicine

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Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

Hulscher,

Hodkinson,

Makis

et al. 2024

ESC Heart Failure

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COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis. We performed a systematic review of all published autopsy reports involving COVID‐19 vaccination‐induced myocarditis through 3 July 2023. All autopsy studies that include COVID‐19 vaccine‐induced myocarditis as a possible cause of death were included. Causality in each case was assessed by three independent physicians with cardiac pathology experience and expertise. We initially identified 1691 studies and, after screening for our inclusion criteria, included 14 papers that contained 28 autopsy cases. The cardiovascular system was the only organ system affected in 26 cases. In two cases, myocarditis was characterized as a consequence from multisystem inflammatory syndrome. The mean age of death was 44.4 years old. The mean and median number of days from last COVID‐19 vaccination until death were 6.2 and 3 days, respectively. We established that all 28 deaths were most likely causally linked to COVID‐19 vaccination by independent review of the clinical information presented in each paper. The temporal relationship, internal and external consistency seen among cases in this review with known COVID‐19 vaccine‐induced myocarditis, its pathobiological mechanisms, and related excess death, complemented with autopsy confirmation, independent adjudication, and application of the Bradford Hill criteria to the overall epidemiology of vaccine myocarditis, suggests that there is a high likelihood of a causal link between COVID‐19 vaccines and death from myocarditis.

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An autopsy case report of aortic dissection complicated with histiolymphocytic pericarditis and aortic inflammation after mRNA COVID-19 vaccination

Cited by 8 publications

References 18 publications

An autopsy case report of aortic dissection after mRNA COVID-19 vaccination: correspondence

An autopsy case report of aortic dissection after mRNA COVID-19 vaccination: correspondence

Before blaming SARS-CoV-2 vaccination for aortic dissection, alternative causes need to be ruled out

Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

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