An autoradiographic study of the projections of the mammillothalamic tract in the rat

Cruce, Judith A.F.

doi:10.1016/0006-8993(75)90072-4

Cited by 116 publications

(37 citation statements)

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“…LM is known to send fibers to AD on both sides [Fry et al, 1963;Niimi et al, 1972;Yamadori, 1973;Cruce, 1975;Hop kins and Dekker, 1975;LaVail, 1975;Van der Kooy et al, 1979]. Similar observations were made in this investigation.…”

Section: Discussionsupporting

confidence: 78%

A horseradish peroxidase study on the mammillothalamic tract in the rat

Watanabe

Kawana²

1980

Cells Tissues Organs

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The mammillary projections to the anterior thalamic nuclei were investigated in the rat, using the horseradish peroxidase (HRP) method. Pars centralis of the medial mammillary nucleus projects to the medial portion of the anteromedial nucleus (AM). Pars medialis (Mm) of the medial mammillary nucleus sends fibers to the ipsilateral AM and sparsely to the medial portion of the contralateral side. The ventral and dorsal portions of Mm project to the anterior and posterior portions of AM, respectively. The pars lateralis (Ml) and pars posterior (Mp) of the medial mammillary nucleus send fibers predominantly to the ipsilateral anteroventral nucleus and sparsely to the contralateral side. A slight difference between Ml and Mp projections was observed. The lateral mammillary nucleus projects bilaterally to the anterodorsal nucleus.

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Section: Discussionsupporting

confidence: 78%

A horseradish peroxidase study on the mammillothalamic tract in the rat

Watanabe

Kawana²

1980

Cells Tissues Organs

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“…Most neurons in the medial mammillary bodies have bipolar axons that send processes rostrally to the anterior nucleus of the thalamus via the MT and caudally to the dorsal and ventral tegmental nuclei of the brain stem via the mammillotegmental tract (Cowan et al, 1964;Cruce, 1975Cruce, , 1977Van der Kooy et al, 1978;Veazey et al, 1982a, b). Reciprocal connections from the tegmental nuclei to the MB project anteriorly in the MP.…”

Section: Discussionmentioning

confidence: 99%

Interruption of the connections of the mammillary bodies protects against generalized pentylenetetrazol seizures in guinea pigs

Ma¹,

Ja²

1987

J. Neurosci.

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Electrolytic lesions in the anterior and mid-diencephalon and ventral midbrain in guinea pigs were produced to examine the effects of interruption of the fornix (FX), mammillothalamic tracts (MT), and mammillary peduncles (MP), respectively, on the expression of pentylenetetrazol (PTZ) seizures. As a group, all mid-diencephalic lesioned animals had some degree of protection from the electroencephalographic and behavioral convulsant and lethal effects of the drug. Through a composite volume analysis of protected versus unprotected animals, as well as a retrospective comparison between MT and non-MT lesioned animals, it was demonstrated that small mid-diencephalic lesions incorporating only the MTs and their immediate vicinity were capable of completely preventing the convulsant and lethal effects of PTZ. Lesions of the FX and MP were also protective against PTZ seizures but to a lesser degree than the MT lesions.These results demonstrate that the major afferent and efferent connections of the mammillary bodies are involved in expressing PTZ seizure activity and suggest that the MT may be the major pathway mediating paroxysmal activity from brain stem to the thalamus.The expression of generalized seizures is characterized by bilateral and synchronous activation of cortical and subcortical brain regions. Although the functional anatomy of this convulsive process is yet unclear, substantial evidence suggests that subcortical brain regions, through their widespread cortical connections, play a major role in the propagation and perhaps initiation of these attacks. Early studies demonstrated numerous facilitatory and inhibitory influences on seizure activity in both the brain stem and diencephalon (Morison and Dempsey, 1942;Jasper and Droogleever-Fortuyn, 1946;Hunter and Jasper, 1949; Ingvar, 1955a, b;Ralston and Ajmone-Marsan, 1956;Kriendler et al., 1958;Andy and Mukawa, 1959; Bergman et al., 1963;Guerrero-Figueroa et al., 1963;Weir, 1964) and suggested important roles for diffusely organized regions such as the reticular formations of the pons, mesencephalon, and thalamus. Specific areas of the subcortex have also been associated with seizure mechanisms, including the hypothalamus (Murphy and Gellhorn, 1945;Jasper and Droogleever-Fortuyn, 1946; Green and Received Jan. 13, 1986; revised Aug. 28, 1986; accepted Sept. 4, 1986 (Jinnai, 1966;Jinnai et al., 1969;Jinnai and Mukawa, 1970), substantia nigra (Iadarola and Gale, 1982;Garant and Gale, 1983;Gonzalez and Hettinger, 1984; McNamara et al., 1983McNamara et al., , 1984, and several thalamic nuclei (Mullen et al., 1967;Jinnai et al., 1969;Feeney and Gullotta, 1972;Kusske et al., 1972;Van Straaten, 1975;Quesney et al., 1977).Recently we observed the selective metabolic activation of the mammillary bodies (MB) and their immediate connections during a threshold convulsive stimulus induced by the co-infusion of pentylenetetrazol (PTZ) and ethosuximide (ESM) (Mirski and Ferrendelli, 1983). We also reported preliminary data demonstrating that the interruption of the mamm...

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“…The physiological role of type I IL-1 receptors in the anterodorsal thalamic nucleus, a region best known as a limbic relay between the mammillary complex in the posterior hypothalamus and the cingulate cortex (Cruce, 1975;Beckstead, 1976), is at present unclear. Similarly, the effect of IL-l on sensory neurons of the mesencephalic trigeminal nucleus, and on Purkinje cells of the cerebellar cortex, has yet to be addressed.…”

Section: Discussionmentioning

confidence: 99%

In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse

et al. 1992

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The cytokine interleukin-1 (IL-l) has a number of biologic activities, including pronounced effects on the nervous and neuroendocrine systems. In this study, in situ histochemical techniques were used to investigate the distribution of cells expressing type I IL-1 receptor mRNA in the CNS, pituitary, and adrenal gland of the mouse. Hybridization of %-labeled antisense cRNA probes derived from a murine T-cell IL-1 receptor cDNA revealed a distinct regional distribution of the type I IL-1 receptor, both in brain and in the pituitary gland. In the brain, an intense signal was observed over the granule cell layer of the dentate gyrus, over the entire midline raphe system, over the choroid plexus, and over endothelial cells of postcapillary venules throughout the neuraxis. A weak to moderate signal was observed over the pyramidal ceil layer of the hilus and CA3 region of the hippocampus, over the anterodorsal thalamic nucleus, over Purkinje cells of the cerebellar cortex, and in scattered clusters over the externalmost layer of the median eminence.In the pituitary gland, a dense and homogeneously distributed signal was observed over the entire anterior lobe. No autoradiographic signal above background was observed over the posterior and intermediate lobes of the pituitary, or over the adrenal gland. This study therefore provides evidence for discrete receptor substrates subserving the central effects of IL-l, thus supporting the notion that IL-1 acts as a neurotransmitter/neuromodulator in brain. It also supports studies suggesting that IL-1 -mediated activation of the hypothalamic-pituitary-adrenal axis occurs primarily at the level of the brain and/or pituitary gland.Interleukin-1 (IL-l) is one of a growing number of cytokines that mediate important regulatory interactions between lymphocytes and many other cell types (see Dinarello, 1989). IL-l has also been identified as a key mediator in the acute-phase

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An autoradiographic study of the projections of the mammillothalamic tract in the rat

Cited by 116 publications

References 1 publication

A horseradish peroxidase study on the mammillothalamic tract in the rat

A horseradish peroxidase study on the mammillothalamic tract in the rat

Interruption of the connections of the mammillary bodies protects against generalized pentylenetetrazol seizures in guinea pigs

In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse

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