An autoradiographic study of the efferent connections of the preoptic region in the rat

Lw, Swanson

doi:10.1002/cne.901670207

Cited by 578 publications

(169 citation statements)

References 48 publications

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“…Nevertheless, the few previous pathway-tracing studies (Swanson, 1976;Conrad and Pfaff, 1976) are consistent with the present data, and a recent study indicating participation of the MPO in social defensive responses (Motta et al, 2009) is also consistent with a connectionindicated involvement of the LHAjd in the same. The conspicuous absence of definitive studies of the MPO and internuclear area reflects an issue that has, until recently, also applied to the LHA, namely, the absence of a definitive (at least provisionally) parcellation scheme.…”

Section: Cerebrospinal Trunk: Motor Systemsupporting

confidence: 93%

“…4T-Y). In contrast to extensive investigations of the medial preoptic nucleus (MPN), only a few studies (and none recent) have provided a (partial) overview of the connections of the MPN-surrounding MPO (Swanson, 1976;Conrad and Pfaff, 1976), and none has specifically addressed MPO function.Nevertheless, the few previous pathway-tracing studies (Swanson, 1976;Conrad and Pfaff, 1976) are consistent with the present data, and a recent study indicating participation of the MPO in social defensive responses (Motta et al, 2009) is also consistent with a connectionindicated involvement of the LHAjd in the same. The conspicuous absence of definitive studies of the MPO and internuclear area reflects an issue that has, until recently, also applied to the LHA, namely, the absence of a definitive (at least provisionally) parcellation scheme.…”

mentioning

confidence: 99%

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Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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The connections of the lateral hypothalamic area juxtadorsomedial region (LHAjd) were investigated in a series of pathway-tracing experiments involving iontophoretic co-injection of the tracers Phaseolus vulgaris-leucoagglutinin (PHA-L; for outputs) and cholera toxin B subunit (CTB; for inputs). Results revealed that the LHAjd has connections with some 318 distinct gray matter regions encompassing all four subsystems-motor, sensory, cognitive, and behavioral state -included in a basic structure-function network model of the nervous system. Integration of these subsystems is necessary for the coordination and control of emotion and behavior, and in that regard the connections of the LHAjd indicate that it may have a prominent role. Furthermore, the LHAjd connections, together with the connections of other LHA differentiations studied similarly to date, indicate a distinct topographic organization that suggests each LHA differentiation has specifically differing degrees of involvement in the control of multiple behaviors. For the LHAjd, its involvement to a high degree in the control of defensive behavior, and to a lesser degree in the control of other behaviors, including ingestive and reproductive, is suggested. Moreover, the connections of the LHAjd suggest that its possible role in the control of these behaviors may be very broad in scope because they involve the somatic, neuroendocrine, and autonomic divisions of the nervous system. In addition, we suggest that connections between LHA differentiations may provide, at the level of the hypothalamus, a neuronal substrate for the coordinated control of multiple themes in the behavioral repertoire. INDEXING TERMShypothalamus; periaqueductal gray; hippocampal formation; behavior; motivation An emerging view of the lateral hypothalamic area (LHA) reveals a highly regionally differentiated neuronal architecture with correspondingly differentiated axonal connections characterized by an extensive divergent and convergent topographic organization (Swanson, 2004;Goto et al., 2005;Swanson et al., 2005;Hahn, 2010;Hahn and Swanson, 2010). Such an organization calls for an equivalently extensive comparative analysis of the underlying organization of the severally parceled LHA (16 provisional LHA regions within the hypothalamic lateral zone) (Swanson, 2004). In a previous article (Hahn and Swanson, 2010), we presented the results of a high-resolution analysis of the axonal inputs and outputs of the lateral hypothalamic area (LHA) juxtaparaventricular (LHAjp) and suprafornical (LHAs) regions-two differentiations of the hypothalamic lateral zone middle group within NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript respectively a medial (LHAjp) and perifornical (LHAs) tier of a recently revised parcellation for the LHA (Swanson, 2004;Swanson et al., 2005).The previous work showed that the LHAjp and LHAs have interregional connections with several hundred distinct gray matter regions encompassing all four subsystems (motor, sensory, cognitive, and...

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Section: Cerebrospinal Trunk: Motor Systemsupporting

confidence: 93%

mentioning

confidence: 99%

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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“…However, in consideration of the evidence that labeled areas are anatomically related to the limbic system (NAUTA and HAYMAKER, 1969;SWANSON, 1976), the present results suggest that this pathway may influence visual stimuli upon the limbic system.…”

Section: Discussionmentioning

confidence: 46%

Termination of retinal fibers in lateral preoptic and hypothalamic areas of the crab-eating monkey, Macaca irus.

Nakagawa¹,

Tamai

Yasui

et al. 1982

Arch. Histol. Jap., Arch. Histol. Jpn

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“…In mammals, fibers from some olfactory forebrain areas were reported to travel in the SM, without sending collaterals to the HG (Herkenham and Nauta 1977). It was also reported that fibers from the substantia innominata projected to its own contralateral counterpart via the HC (Price and Powell 1970;Swanson 1976). …”

Section: Discussionmentioning

confidence: 99%

A Golgi Study on the Afferent Fibers to the Habenular Ganglion in the Red Stingray, Dasyatis akajei

Iwahori

Nakamura

Kameda

1991

Okajimas Folia Anatomica Japonica

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Summary: Afferent fibers to the habenular ganglion (HG) were derived mainly from the stria medullaris thalami (SM), which was roughly divided into a dorsal and ventral bundle. In the left ganglion seen at the level of the rostrocaudal middle, the dorsal bundle gave off collaterals to the lateral habenular nucleus (LH) and dorsal subnucleus of the medial habenular nucleus (MH), while the ventral bundle innervated the intermediate and ventral subnuclei of the MH. On the other hand, in the right ganglion at the level of the rostrocaudal middle, the dorsal subnucleus of the MH was innervated by collaterals from the dorsal bundle of the SM, whereas in the intermediate and ventral subnucleus fibers from the ventral bundle were seen. In the left ganglion at the caudal level, the dorsal and ventral bundle extended medially and joined the same bundle of the opposite side to constitute a dorsal and intermediate component of the habenular commissure, respectively. A third component of the HC, a ventral component, was seen to run between the fasciculus retroflexus of both sides. As in the case of the rostral level, the dorsal bundle of the SM emitted collaterals to the LH and dorsal subnucleus of the MH, while the intermediate and ventral subnuclei of the MH were projected upon by collaterals from the ventral bundle of the SM. At the caudal level of the right ganglion, the dorsal bundle gave off collaterals to the dorsal subnucleus of the MH. In contrast, the LH and the intermediate and ventral subnuclei of the MH were innervated by fibers from the ventral bundle. With regard to terminal patterns of the SM, fibers to the MH gave off many short fine branchlets forming the glomerular structures, whereas those to the LH branched out into numerous terminals to form a dense fiber plexus. Thus, the afferent fibers to the HG in the red stingray exhibited a striking left-right asymmetry.The habenular ganglion (HG) has been known to receive afferents from various brain regions. In mammals, terminal patterns of the afferent fibers in the HG was studied in detail using the rapid Golgi method (RamOn y Cajal 1911;Iwahori 1977) as well as the experimental methods (Herkenham and Nauta 1977). The afferent fibers to the selachian HG have been studied by numerous investigators (Edinger 1892;Haller 1898;Ariens Kappers 1906;Sterzi 1909;Ariens Kappers and Carpenter 1911;Johnston 1911;Bergquist 1932;Addens 1945;Farner 1978;Smeets, Nieuwenhuys and Roberts 1983). In these studies, however, the afferent fibers were analyzed mainly in myelin stained sections and minute terminal patterns of the afferents have not been fully elucidated. As was shown in our previous study (Iwahori, Nakamura and Kameda 1991), the neuronal organization of the HG in the red stingray exhibited the striking left-right asymmetry. In order to understand the characteristic features of the structural asymmetry, information on the minute organization of the afferent fibers is needed.Such being the case, a Golgi analysis of the afferent fibers to the HG was attempted.In the prese...

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An autoradiographic study of the efferent connections of the preoptic region in the rat

Cited by 578 publications

References 48 publications

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Termination of retinal fibers in lateral preoptic and hypothalamic areas of the crab-eating monkey, Macaca irus.

A Golgi Study on the Afferent Fibers to the Habenular Ganglion in the Red Stingray, Dasyatis akajei

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