An avian influenza A virus killing a mammalian species ? the mink

Klingeborn, B.; Englund, Lena; Rott, R.; Juntti, N.; Rockborn, G.

doi:10.1007/bf01309839

Cited by 100 publications

(67 citation statements)

References 7 publications

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“…These viruses, which were of avian origin (H1ON4), caused systemic infection and disease in the mink and spread to contacts (90). The potential susceptibility of mink to influenza A viruses from a variety of animal species had been demonstrated experimentally before this outbreak (108,126).…”

Section: Influenza Viruses In Pigsmentioning

confidence: 99%

Evolution and Ecology of Influenza A Viruses

Yoon

Webby

Webster

2014

Current Topics in Microbiology and Immunology

295

292

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Section: Influenza Viruses In Pigsmentioning

confidence: 99%

Evolution and Ecology of Influenza A Viruses

Yoon

Webby

Webster

2014

Current Topics in Microbiology and Immunology

295

292

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“…H10N7 viruses were found to cause sporadic human infection cases in Egypt in 2004 (11) and in Australia in 2010 (12). An H10N4 outbreak in mink was observed in 1984 (13), and an H10N5 virus was detected in swine in 2008 (14). All of these were short-term and isolated events.…”

mentioning

confidence: 99%

Emergence and Evolution of H10 Subtype Influenza Viruses in Poultry in China

Lam

Chai

et al. 2015

J Virol

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The cases of human infections with H10N8 viruses identified in late 2013 and early 2014 in Jiangxi, China, have raised concerns over the origin, prevalence, and development of these viruses in this region. Our long-term influenza surveillance of poultry and migratory birds in southern China in the past 12 years showed that H10 influenza viruses have been introduced from migratory to domestic ducks over several winter seasons at sentinel duck farms at Poyang Lake, where domestic ducks share their water body with overwintering migratory birds. H10 viruses were never detected in terrestrial poultry in our survey areas until August 2013, when they were identified at live-poultry markets in Jiangxi. Since then, we have isolated 124 H10N8 or H10N6 viruses from chickens at local markets, revealing an ongoing outbreak. Phylogenetic analysis of H10 and related viruses showed that the chicken H10N8 viruses were generated through multiple reassortments between H10 and N8 viruses from domestic ducks and the enzootic chicken H9N2 viruses. These chicken reassortant viruses were highly similar to the human isolate, indicating that market chickens were the source of human infection. Recently, the H10 viruses further reassorted, apparently with H5N6 viruses, and generated an H10N6 variant. The emergence and prevalence of H10 viruses in chickens and the occurrence of human infections provide direct evidence of the threat from the current influenza ecosystem in China. IMPORTANCEAfter the outbreak of avian-origin H7N9 influenza viruses in China, fatal human infections with a novel H10N8 virus were reported. Utilizing data from 12 years of influenza surveillance in southern China, we showed that H10 viruses were regularly introduced by migratory ducks to domestic ducks on Poyang Lake, a major aggregative site of migratory birds in Asia. The H10 viruses were maintained and amplified in domestic ducks and then transmitted to chickens and reassorted with enzootic H9N2 viruses, leading to an outbreak and human infections at live-poultry markets. The emergence of the H10N8 virus, following a pathway similar to that of the recent H7N9 virus, highlights the role of domestic ducks and the current influenza ecosystem in China that facilitates influenza viruses moving from their reservoir hosts through the live-poultry system to cause severe consequences for public health.

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“…However, an influenza virus outbreak in a mink population associated with the development of clinical signs in infected animals is a rare event, and it has been reported only on a few occasions, such as the 1984 Sweden outbreak caused by an avian H10N4 influenza virus (12). Therefore, it is believed that most of the natural influenza virus infections in mink are asymptomatic, with the consequence that no specific influenza virus subtype has been known to circulate in the mink population.…”

mentioning

confidence: 99%

Characterization of a Canadian Mink H3N2 Influenza A Virus Isolate Genetically Related to Triple Reassortant Swine Influenza Virus

et al. 2009

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In 2007, an H3N2 influenza A virus was isolated from Canadian mink. This virus was found to be phylogenetically related to a triple reassortant influenza virus which emerged in Canadian swine in 2005, but it is antigenically distinct. The transmission of the virus from swine to mink seems to have occurred following the feeding of animals with a ration composed of uncooked meat by-products of swine obtained from slaughterhouse facilities. Serological analyses suggest that the mink influenza virus does not circulate in the swine population. Presently, the prevalence of influenza virus in Canadian farmed and wild mink populations is unknown. The natural occurrence of influenza virus infection in mink with the presence of clinical signs is a rare event that deserves to be reported.

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An avian influenza A virus killing a mammalian species ? the mink

Cited by 100 publications

References 7 publications

Evolution and Ecology of Influenza A Viruses

Evolution and Ecology of Influenza A Viruses

Emergence and Evolution of H10 Subtype Influenza Viruses in Poultry in China

Characterization of a Canadian Mink H3N2 Influenza A Virus Isolate Genetically Related to Triple Reassortant Swine Influenza Virus

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