An early assessment of the efficacy of medicines in the treatment of patients with COVID-19

Колбин, А. С.

doi:10.15789/2220-7619-aea-1458

Cited by 4 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We believe that taking a drug in preventive doses does not exclude the possibility of infection with SARS-CoV-2, but against its background, there is an earlier recovery and smoothness of clinical symptoms, probably due to the antiinflammatory properties of the drug. The results obtained correspond to the data of the literature sources [6,7]. Thus, the risk group for occupational infection was dominated by middleaged women from among secondary and junior medical personnel with an appropriate level of education and, probably, the level of perception of new information associated with education.…”

Section: Resultssupporting

confidence: 84%

Socio-Economic Interaction – Addressing Problems of Safety in the Community

Tverdynin¹,

Grishakina²,

Тихонова³

et al. 2021

Proceedings of International Scientific and Practical Conference “Russia 2020 - A New Reality: Economy and Society” (ISPCR 2020

View full text Add to dashboard Cite

Modern society is fundamentally different from all human communities that existed during the development of world civilization. The world has become a technosociety with a number of characteristics that cannot be correlated with the formations existed before. We can talk about an established society, where scientific and technological progress is not only a guarantee of development, but also a condition for existence, which is very noticeable in such areas as healthcare, energy industry, and the production of various materials. Unlike all previous civilizations, this society has a number of separate social segments that are not only interconnected, but also interdependent. Such a structure, which has no analogues in the past, requires a new approach to education, which should simultaneously be both highly-specialized and interdisciplinary, while performing both formative and educational functions. The safety of the modern world largely depends on the correct balance of educational principles, on the quality of education, as in the case of manmade disasters (Chernobyl and Fukushima) and the SARS-CoV-2 (COVID-19) viral pandemic in 2020. These events became agents for new methods of assessing the various factors mutual influence on such phenomena. At the same time, there is an interest in creating private methods that allow predicting the possible effectiveness of various economic and other measures to reduce the risk of emergencies and improve safety.

show abstract

Section: Resultssupporting

confidence: 84%

Socio-Economic Interaction – Addressing Problems of Safety in the Community

Tverdynin¹,

Grishakina²,

Тихонова³

et al. 2021

Proceedings of International Scientific and Practical Conference “Russia 2020 - A New Reality: Economy and Society” (ISPCR 2020

View full text Add to dashboard Cite

show abstract

“…Важность РКИ для современной медицины сложно переоценить. Даже в неблагоприятных эпидемиологических условиях распространения вируса SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus), для поиска новых эффективных препаратов проводятся РКИ [43][44][45][46][47]. Одним из важных аспектов при проведении РКИ является выбор КТ.…”

Section: заключениеunclassified

Endpoints: types, selection, interpretation of the results obtained on the example of cardiology studies

Navasardyan

Martsevich²

2022

Cardiovasc Ther Prev

View full text Add to dashboard Cite

The importance of high-quality randomized controlled trials cannot be overemphasized. Each such study attempts to answer a specific clinical question. To do this, it is necessary to determine in advance the indicator of achievement of a specific result for a certain period of time. This indicator is the endpoint (EP) of the study, i.e. one or another outcome of the disease or a change in the laboratory and functional characteristics. Its choice directly affects the intended design and sample size of the study. The article provides a classification and hierarchy of EPs (depending on the purpose), describes the features and limitations of the use of important clinical outcomes and surrogate indicators. The reasons why composite EPs are widely used in cardiology studies are described. Special attention should be paid to EP interpretation within secondary analysis, a positive result of which can only be assessed if a treatment effect is demonstrated in terms of the primary indicator of efficacy or safety. The current review is supplemented by clinical examples of cardiology studies.

show abstract

“…"Protease inhibitor: lopinavir/ritonavir is one of the first drugs to be recommended for the treatment of COVID-19" [7, p. 16-17] Protease inhibitors include darunavir, which has at least been studied in only one (2020 data) clinical trial on an in vivo model. [6,8].…”

Section: Protease Inhibitors: Lopinavir / Ritonavir Darunavir and Dan...mentioning

confidence: 99%

Models And Pharmacological Approaches to The Study of Endothelioprotective Properties of Drugs Used to Treat Coronavirus Infection Covid-19 - Requirements for The Construction and Application of The Model

Kanisov¹

2022

PDD

View full text Add to dashboard Cite

In addition to the appearance of a functionally multi-connected model of the object under study, we observe another feature: the SARS-CoV-2 virus penetrates into the cell for a short time, after replication, from the infected cell penetrates into a neighboring cell. And the peculiarity lies in the fact that the replication of the virus penetrates into a neighboring cell along the path of direct contact. Observation and detection of the SARS-CoV-2 virus in various environments and tissues of the body indicates that the virus is able to overcome cellular barriers, as mentioned above, without passing through the receptor channels known to us.

show abstract

An early assessment of the efficacy of medicines in the treatment of patients with COVID-19

Cited by 4 publications

References 27 publications

Socio-Economic Interaction – Addressing Problems of Safety in the Community

Socio-Economic Interaction – Addressing Problems of Safety in the Community

Endpoints: types, selection, interpretation of the results obtained on the example of cardiology studies

Models And Pharmacological Approaches to The Study of Endothelioprotective Properties of Drugs Used to Treat Coronavirus Infection Covid-19 - Requirements for The Construction and Application of The Model

Contact Info

Product

Resources

About