An Early Finding of Keratoconus: Increase in Corneal Densitometry

Koç, Mustafa; Tekin, Kemal; Tekin, Merve Inanc; Uzel, Mehmet Murat; Kösekahya, Pınar; Özülken, Kemal; Yılmazbaş, Pelin

doi:10.1097/ico.0000000000001537

Cited by 54 publications

(44 citation statements)

References 23 publications

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“…In a recent study in our country; It has been stated that with Pentacam Scheimp flug tomography analysis, most, if not all, subclinical keratoconus cases can be detected, and the detection of increased corneal light back distribution may be a more sensitive way to identify keratoconus in its early stages (30). In the same study, it was stated that the increase in densitometry in the central zone could be useful in detecting subclinical keratoconus (30).…”

Section: Discussionmentioning

confidence: 93%

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Evaluation of Anterior Segment Parameters in Patients With Keratoconus With Pentacam Device

Kaşıkçı

Eroğul

2021

Kocatepe Tıp Dergisi

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Keratokonus hastalarında hastalığın şiddetine göre ön segment parametrelerinde gözlenen değişikliklerin Pentacam cihazı kullanılarak değerlendirilmesi ve elde edilen ölçümlerin sağlıklı bireylerden elde edilen ölçümler ile karşılaştırılması amaçlanmıştır. GEREÇ VE YÖNTEM:Elli iki keratokonus hastasının 104 gözü ile 60 sağlıklı bireyin 120 gözüne ait Pentacam cihazı verileri retrospektif olarak değerlendirildi. Hastaların demografik özellikleri, korneal ön yüzey ve arka yüzeye ait kurvatür, asferite ve elevasyon değerleri (K1, K2, korneal astigmatizma ve ortalama asferite) ile en ince korneal kalınlık (TCT), apeks korneal kalınlık (ACT), korneal volüm (CV), ön kamara derinliği (ACD), ön kamara açısı (ACA) ve ön kamara volümü (ACV)değerleri kaydedildi.BULGULAR: Keratokonus grubunda (22 Kız, 30 Erkek) ortalama yaş 30.8±11.6 yıl, kontrol grubunda (26 Kız, 34 Erkek) 32.4±12.4 yıl idi. Gruplar yaş ve cinsiyet açısından uyumlu idi (sırasıyla p=0.32, p=0.89). Keratometri değerlerine göre yapılan sınıflamaya göre keratokonus seviyesi 63 göz hafif, 26 göz orta ve 15 gözde ağır keratokonus olarak gruplandı. Keratokonus hastalarında gruplar arasında korneal ön yüzey ve arka yüzeye ait kurvatür, asferite ve elevasyon değerlerinde anlamlı fark bulundu (p<0.001). TCT hafif grupta en yüksek, ağır grupta en düşük saptandı ve gruplar arasındaki fark anlamlı idi (p<0.05). ACD hafif grupta 3.21±0.34, orta grupta 3.27±0.26 ve ağır grupta ise 3.79±0.53 idi ve aradaki fark anlamlı bulundu (p<0.05). SONUÇ: Keratokonus progresyonu ile korneal ön yüzey ve arka yüzeye ait kurvatür, asferite ve elevasyon değerleri ile kornea ön segment parametrelerinde anlamlı değişiklikler gözlenmektedir.

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Section: Discussionmentioning

confidence: 93%

“…The average age was 30.8±11.6 years in the Keratoconus group (22 Female,30 Male) and 32.4±12.4 years in the control group (26 Female,34 Male). The groups were compatible with each other in terms of age and gender (p=0.32, p=0.89, respectively).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Anterior Segment Parameters in Patients With Keratoconus With Pentacam Device

Kaşıkçı

Eroğul

2021

Kocatepe Tıp Dergisi

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“…Hence, the patients in the study must be evaluated by using these analyses. The studies by us 4 and Bae et al 5 revealed that even these analyses are not adequate to detect the subclinical keratoconus. We examined the medical records of 3474 patients with keratoconus and 116 (3.3%) cases with subclinical keratoconus were detected.…”

Section: Dear Editormentioning

confidence: 96%

Topography and Higher Order Corneal Aberrations of the Fellow Eye in Unilateral Keratoconus

Koç¹,

Tekin²

2018

tjo

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“…To overcome the current screening limitations, Koc and colleagues 12 analyzed the asymptomatic eyes of patients with very asymmetric ectasia ( n = 38) and concluded that densitometric analysis might detect subclinical keratoconus earlier than topographic, topometric, and tomographic analyses. 12 Densitometry is an objective and automatic tool to measure corneal transparency.…”

Section: Introductionmentioning

confidence: 99%

Detection of Subclinical Keratoconus With a Validated Alternative Method to Corneal Densitometry

Consejo

Jiménez‐García

Issarti

et al. 2021

Trans. Vis. Sci. Tech.

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Purpose To enhance the current standards of subclinical keratoconus screening based on the statistical modeling of the pixel intensity distribution of Scheimpflug images. Methods Scheimpflug corneal tomographies corresponding to 25 corneal meridians of 60 participants were retrospectively collected and divided into three groups: controls (20 eyes), subclinical keratoconus (20 eyes), and clinical keratoconus (20 eyes). Only right eyes were selected. After corneal segmentation, pixel intensities of the stromal tissue were statistically modeled using a Weibull probability density function from which parameter α (pixel brightness) was derived. Further, data were transformed to polar coordinates, smoothed, and interpolated to build a map of the corneal α parameter. The discriminative power of the method was analyzed using receiver operating characteristic curves. Results The proposed platform-independent method achieved a higher performance in discriminating subclinical keratoconus from control eyes (90.0% sensitivity, 95.0% specificity, 0.97 area under the curve [AUC]) than the standard method (Belin–Ambrósio enhanced ectasia display), which uses only corneal morphometry (85.0% sensitivity, 85.0% specificity, 0.80 AUC). Conclusions Analysis of light backscatter at the cornea successfully discriminates subclinical keratoconus from control eyes, upgrading the results previously reported in the literature. Translational Relevance The proposed methodology has the potential to support clinicians in the detection of keratoconus before showing clinical signs.

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An Early Finding of Keratoconus: Increase in Corneal Densitometry

Abstract: The increase in densitometry in the central zone could be useful in detecting subclinical keratoconus.

Cited by 54 publications

References 23 publications

Evaluation of Anterior Segment Parameters in Patients With Keratoconus With Pentacam Device

Evaluation of Anterior Segment Parameters in Patients With Keratoconus With Pentacam Device

Topography and Higher Order Corneal Aberrations of the Fellow Eye in Unilateral Keratoconus

Detection of Subclinical Keratoconus With a Validated Alternative Method to Corneal Densitometry

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