An easy method for the intraluminal administration of peppermint oil before colonoscopy and its effectiveness in reducing colonic spasm

Asao, Takayuki; Mochiki, Erito; Suzuki, Hitoshi; Nakamura, Junichi; Hirayama, Isao; Morinaga, Nobuhiro; Shoji, Hisanori; Shitara, Yoshinori; Kuwano, Hiroyuki

doi:10.1067/mge.2000.108477

Cited by 75 publications

(69 citation statements)

References 18 publications

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“…Peppermint oil has a satisfactory spasmolytic effect on the smooth musculature of colon. Asao et al [47] instilled a solution of peppermint oil through the accessory channel of the colonscope in 409 patients undergoing colonoscopy. About twenty seconds later, they documented a relaxation of the musculature that lasted about twenty minutes.…”

Section: New Endoscopic Technologies For Colon Examinationmentioning

confidence: 99%

Colonoscopy, pain and fears: Is it an indissoluble trinomial?

Trevisani

Zelante

Sartori

2014

WJGE

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Colonoscopy is the reference method in the secondary prevention, diagnosis and, in some cases, treatment of colorectal cancer. It can often cause pain associated with embarrassment, anxiety, and physical and emotional discomfort. Pain intensity is influenced by a lot of factors, and there is a strict relationship among pain, pain perception, and mind. Several methods can be used to break the trinomial colonoscopy, pain and fear. Sedoanalgesia is recommended by several guidelines. If no sedation is offered, the patient must accept a higher chance of unacceptable discomfort and the endoscopist a lower chance of completing the procedure because of patient discomfort. Other non-pharmacologic methods such as acupuncture, music, and hydrocolonoscopy can be used as alternatives to pharmacologic sedoanalgesia. Furthermore, new endoscopic technologies such as variable-stiffness colonoscopes and ultrathin colonoscopes, or the use of carbon dioxide instead of air for colon insufflation, can reduce the pain caused by colonoscopy. In the future, technical improvements such as wireless capsules or robotic probes, will probably enable to overcome the present concept of colonoscopy, avoiding the use of traditional endoscopes. However, at present the poor attention paid by endoscopists to the pain and discomfort caused by colonoscopy can not be justified. There are several methods to reduce pain and anxiety and to break the trinomial colonoscopy, pain and fear. We must use them.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Colonoscopy; Pain; Fear; Anxiety; Discomfort; Conscious sedation Core tip: Colonoscopy can often cause pain associated with embarrassment, anxiety, and physical and emotional discomfort. Control of discomfort and pain during colonoscopy is considered to be a high priority by patients. This review of the literature encompasses the main methods for reducing pain and anxiety, to break the trinomial colonoscopy, pain and fear.

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Section: New Endoscopic Technologies For Colon Examinationmentioning

confidence: 99%

Colonoscopy, pain and fears: Is it an indissoluble trinomial?

Trevisani

Zelante

Sartori

2014

WJGE

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“…In the scientific literature, peppermint oil was reported to be an effective treatment for nausea and vomiting [10], and its intraluminal administration was found to be a simple, safe, and convenient alternative for the prevention and amelioration of colonic spasms caused by endoscopy [44,45]. In addition, peppermint oil has been used to treat irritable bowel disease [46].…”

Section: Discussionmentioning

confidence: 99%

Menthol Modulates Pacemaker Potentials through TRPA1 Channels in Cultured Interstitial Cells of Cajal from Murine Small Intestine

Kim

Wie

So³

et al. 2016

Cell Physiol Biochem

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Background/Aims: ICCs are the pacemaker cells responsible for slow waves in gastrointestinal (GI) smooth muscle, and generate periodic pacemaker potentials in current-clamp mode. Methods: The effects of menthol on the pacemaker potentials of cultured interstitial cells of Cajal (ICCs) from mouse small intestine were studied using the whole cell patch clamp technique. Results: Menthol (1 - 10 μM) was found to induce membrane potential depolarization in a concentration-dependent manner. The effects of various TRP channel antagonists were examined to investigate the receptors involved. The addition of the TRPM8 antagonist, AMTB, did not block menthol-induced membrane potential depolarizations, but TRPA1 antagonists (A967079 or HC-030031) blocked the effects of menthol, as did intracellular GDP_βS. Furthermore, external and internal Ca²⁺ levels were found to depolarize menthol-induced membrane potentials, whereas external Na⁺ was not. Y-27632 (a Rho kinase inhibitor), SC-560 (a selective COX 1 inhibitor), NS-398 (a selective COX 2 inhibitor), ozagrel (a thromboxane A2 synthase inhibitor) and SQ-29548 (highly selective thromboxane receptor antagonist) were used to investigate the involvements of Rho-kinase, cyclooxygenase (COX), and the thromboxane pathway in menthol-induced membrane potential depolarizations, and all inhibitors were found to block the effect of menthol. Conclusions: These results suggest that menthol-induced membrane potential depolarizations occur in a G-protein-, Ca²⁺-, Rho-kinase-, COX-, and thromboxane A₂-dependent manner via TRPA1 receptor in cultured ICCs in murine small intestine. The study shows ICCs are targeted by menthol and that this interaction can affect intestinal motility.

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“…Pinaverium is a calcium channel blocker which acts selectively on the gastrointestinal tract; it has been found to reduce the duration of abdominal pain in randomized, placebo-controlled studies of adult patients with irritable bowel syndrome [ 170,171 ] . Peppermint oil is believed to be a calcium channel blocker which has been found to relax the lower esophageal sphincter, and reduce colonic spasms in patients undergoing colonoscopy [ 172,173 ] . It has been found in doubleblind randomized controlled studies to be effective in treating children and adults with irritable bowel syndrome [ 174,175 ] and in metaanalysis studies of published trials, it was found to be effective in the treatment of both adults and children with irritable bowel syndrome [ 176,177 ] .…”

Section: Calcium Channel Blockersmentioning

confidence: 99%