An eco-compatible multicomponent strategy for the synthesis of new 2-amino-6-(1H-indol-3-yl)-4-arylpyridine-3,5-dicarbonitriles in aqueous micellar medium promoted by thiamine-hydrochloride

Multicomponent Reactions Accelerated by Aqueous Micelles

“…The synthesis of 4-aryl-2-aminocyanopyridine derivatives ( 26 ) containing indole moieties catalyzed by VB1 (thiamine hydrochloride) in micellar media was reported by Fatma et al ( 2014 ) (Supplementary Table 1 , entry 10). Among all tested surfactants, the most efficient for the four-component reaction was CTAB.…”

One‐Pot Synthesis of 2‐Amino‐6‐(1,2‐dihydro‐4‐hydroxy‐2‐oxoquinolin‐3‐yl)‐4‐arylpyridine‐3‐carbonitriles Catalysed by NbCl5 and Their In Vitro Antimicrobial Studies

“…Pyridine containing heterocyclic compounds have extensive pharmacological activities and its derivatives have gained wide acceptance in clinical practice. Similarly 2‐amino‐3‐cyanopyridines have been attracted due to their promising biological activities and also these compounds are useful intermediates to prepare various heterocyclic compounds . Keeping all in mind 2‐amino‐6‐(1, 2‐dihydro‐4‐hydroxy‐2‐oxoquinolin‐3‐yl)‐4‐arylpyridine‐3‐carbonitriles have been recently synthesized by us starting from 3‐acetyl‐4‐hydroxyquinolin‐2(1H)‐one in two‐steps .…”

“…Also MCR is a green technique, provides rapid and straightforward access to complex molecules in one‐pot without isolating intermediates . Various methods have been reported on preparation of 2‐amino‐3‐cyano pyridines starting from ketones, malanonitrile, ammonium acetate, and aldehydes. Among them MCR has been significantly attracted than multi step synthesis.…”

Synthesis, characterization, and catalytic application of Fe3O4‐Si‐[CH2]3‐N=CH‐aryl for the efficient synthesis of novel poly‐substituted pyridines

“…These compounds have also attracted considerable attention in recent years because of their wide range of applications such as antimalarial, vasodilatory, anesthetic, anticonvulsant, antifungal, pesticidal, and herbicidal drugs . Various acid or base catalysts, ionic liquids, and nanoparticles had been used for the synthesis of pyridine derivatives . However, most of these methods have limitations such as the use of expensive catalysts or toxic solvents, high reaction time, harsh reaction conditions, and difficult work‐up procedures.…”