An eco-friendly strategy, using on-line monitoring and dilution coupled to a second-order chemometric method, for the construction of dissolution curves of combined pharmaceutical associations

Characterization of pharmaceutically relevant materials at the solid state employing chemometrics methods

“…In related studies, we have shown that MCR-ALS can be employed as a chemometrics tool to monitor the simultaneous dissolution of pairs of drugs from fixed doses binary pharmacological associations [126,127], and to use the resulting dissolution curves to build dissolution profiles, useful for comparison between brands or lots, as well as for quality control purposes (Fig. 6).…”

“…Taken from Ref. [126]. used as a chemometric method to interpret X-ray diffractograms of their binary mixtures, revealing that the amount of mannitol and the particle size of ME were important factors in the rate of dissolution [138].…”

Thermally induced solid-state transformation of cimetidine. A multi-spectroscopic/chemometrics determination of the kinetics of the process and structural elucidation of one of the products as a stable N3-enamino tautomer

“…Due to its versatility, MCR-ALS is gaining wide acceptance as a chemometrics tool, suitable for extracting information from complex dynamic systems. MCR-ALS has been applied to the analysis of various evolving mixtures, in order to gain knowledge about their components and corresponding abundances in the samples [54][55][56]. The theoretical background of its operation has been described in Section 2.9.…”

Greener Chromatographic Approaches for Dissolution Testing of Solid Pharmaceutical Formulations

“…Green analytical chemistry represents an important part of green chemistry efforts in research laboratories and manufacturing quality control facilities, with a focus on reducing hydro-organic solvent waste in analytical experiments. − Though savings can be modest, when multiplied by a greater number of individual analytical chemists and tests performed, it can have a significant cumulative impact. Although there has been good effort in using UV-probes and other in situ detection techniques in dissolution testing, the vast majority of dissolution testing still uses high-performance liquid chromatography (HPLC) for sample analysis because of its specificity, robustness, high reproducibility, excellent accuracy, and ease of use. − In fact, HPLC is the most important and broadly used analytical technique in pharmaceutical laboratories . When the use of an off-line analysis technique is employed (i.e., HPLC), the method should be optimized in order to generate the least amount of hydro-organic solvent waste possible, while maintaining a high level of robustness, accuracy, and ease of use.…”