An economical biorefinery process for propionic acid production from glycerol and potato juice using high cell density fermentation

Simultaneous production of lactobionic and gluconic acid in cheese whey/glucose co-fermentation by Pseudomonas taetrolens

“…Impelled by the depletion in carbon sources and the increase in the fermentation costs, the search for alternative feedstocks has become the driving force behind the development of innovative biorefinery approaches targeting the microbial production of organic acids (Dishisha et al, 2013;Lin et al, 2011). Such approaches have the potential to attain a cost-competitive organic acid biomanufacturing while upgrading high-strength polluting biowastes (Alonso et al, 2014).…”

Engineering Propionibacterium freudenreichii subsp. shermanii for enhanced propionic acid fermentation: Effects of overexpressing propionyl-CoA:Succinate CoA transferase

“…It should be noted that a 5% to 10% increase in product yield would be very significant for the economics of propionic acid as a commodity chemical (Stowers et al, 2014). The raw material cost in propionic acid fermentation could account for more than 50% of the final product cost (Dishisha et al, 2013), and the profit margin for commodity chemicals is usually less than $ 5%. Thus, a 5% to 10% increase in product yield could translate into an additional 5% to 10% profit (doubling to tripling the profit margin), which can make the industrial production of biobased propionic acid more competitive with petroleum-based products.…”

Anaerobes in Industrial- and Environmental Biotechnology

“…The bacteria belonging to the genera Propionibacteria produce propionic acid using the Wood Werkman cycle, and, as indicated above, the use of glycerol is advantageous because of its reduced nature and formation of less by-products even though the growth rate is lower compared to the sugar substrate. High cell density fermentations by recycling the free or immobilized cells for repeated fermentations result in higher propionic acid productivity [67,68]. Production of succinic acid using Anaerobiospirillum succiniproducens and Actinobacillus succinogenes from glycerol in the presence of CO 2 has also been investigated [69,70], with reduced formation of the acetic acid by-product.…”