The exponential growth of omic data presents challenges in data manipulation, analysis, and integration. Addressing these challenges, Bioconductor offers an extensive data analysis platform and community, while R tidy programming offers a standard data organisation and manipulation that has revolutionised data science. Bioconductor and tidy R have mostly remained independent; bridging these two ecosystems would streamline omic analysis, ease learning and encourage cross-disciplinary collaborations. Here, we introduce thetidyomicsecosystem—a suite of interoperable software that brings the vast tidy software ecosystem to omic data analysis.