An EEG study of turning freeze in Parkinson's disease patients: The alteration of brain dynamic on the motor and visual cortex

Handojoseno, A. M. Ardi; Gilat, Moran; Ly, Quynh Tran; Chamtie, Hayat; Shine, James M.; Nguyen, Tuan Nghia; Tran, Yvonne; Lewis, Simon J.G.; Nguyen, Hung T.

doi:10.1109/embc.2015.7319910

Cited by 28 publications

(22 citation statements)

References 16 publications

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“…During upright standing, cortical activity was altered in older people 99,107,108 . In people with PD, increased theta and low-gamma cortical power was associated with freezing of gait during turning compared to normal fluent turning 60,61 . However, whether cortical oscillations during walking are truly affected by age or PD remains to be shown in larger future studies.…”

Section: Discussionmentioning

confidence: 91%

“…EEG gamma power over frontal cortices was enhanced in older people during dual-task walking 59 . Theta and low-gamma power was increased during turning with freezing of gait in people with PD compared to normal fluent turning in a number of cortical regions 60,61 . Interestingly, previous research has also demonstrated that people with PD show abnormalities in beta oscillatory activity in the basal ganglia (subthalamic nucleus, STN) and cerebral cortex at rest as well as during movement [62][63][64][65][66][67] .…”

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confidence: 87%

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Corticomuscular control of walking in older people and people with Parkinson’s disease

Roeder

Boonstra

Kerr

2020

Sci Rep

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Changes in human gait resulting from ageing or neurodegenerative diseases are multifactorial. Here we assess the effects of age and Parkinson's disease (PD) on corticospinal activity recorded during treadmill and overground walking. Electroencephalography (EEG) from 10 electrodes and electromyography (EMG) from bilateral tibialis anterior muscles were acquired from 22 healthy young, 24 healthy older and 20 adults with PD. Event-related power, corticomuscular coherence (CMC) and inter-trial coherence were assessed for EEG from bilateral sensorimotor cortices and EMG during the double-support phase of the gait cycle. CMC and EMG power at low beta frequencies (13-21 Hz) was significantly decreased in older and PD participants compared to young people, but there was no difference between older and PD groups. Older and PD participants spent shorter time in the swing phase than young individuals. These findings indicate age-related changes in the temporal coordination of gait. The decrease in lowbeta CMC suggests reduced cortical input to spinal motor neurons in older people during the doublesupport phase. We also observed multiple changes in electrophysiological measures at low-gamma frequencies during treadmill compared to overground walking, indicating task-dependent differences in corticospinal locomotor control. These findings may be affected by artefacts and should be interpreted with caution. Human gait is known to change with age and to be affected by neurodegenerative diseases such as Parkinson's disease (PD). Changes in gait often affect mobility and activities of daily living, and increase the risk for falls, disability, morbidity, and mortality in these populations 1-3. Mechanical and dynamical changes in gait have been well documented. Older adults are known to walk slower, take shorter strides, spend more time in stance and double support, use their hip extensors more, and their ankle plantar flexors and knee extensors less than young individuals 4-10. Movement kinematics, including joint moments and powers at the ankle, and ground reaction forces, also change with ageing 11. PD gait is characterised by slowness, increased variability and impaired postural control 1,12-16. Many stride parameters are altered in people with PD compared to age-matched controls, including decreased walking velocity, stride length, cadence, arm swing, head-trunk control and single support time 17,18. Spatial and temporal gait parameters are also more variable 15 and more asymmetric 1. In addition, PD patients may experience episodic gait disturbances such as freezing or festination of gait 1,12,19. In recent years, treadmill training has been increasingly used to improve gait in PD and its therapeutic effects are greatly discussed. Beneficial effects of treadmill training have been reported for gait speed, step length, stride variability, balance and freezing 20-25. Notably, treadmill walking has been shown to alter gait kinematics and leg muscle activation compared to overground walking in both healthy adults 26-29 and in peo...

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Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 87%

Corticomuscular control of walking in older people and people with Parkinson’s disease

Roeder

Boonstra

Kerr

2020

Sci Rep

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“…During upright standing, cortical activity was altered in older people (Papegaaij et al 2014, Chu & Wong 2018, Ozdemir et al 2018. In people with PD, increased theta and low-gamma cortical power was associated with freezing of gait during turning compared to normal fluent turning (Shine et al 2014, Handojoseno et al 2015. However, whether cortical oscillations during walking are truly affected by age or PD remains to be shown in larger future studies.…”

Section: Changes In Corticomuscular Control With Aging and Parkinson'mentioning

confidence: 89%

“…EEG gamma power over frontal cortices was enhanced in older people during dual-task walking (Marcar et al 2014). Theta and low-gamma power was increased during turning with freezing of gait in people with PD compared to normal fluent turning in a number of cortical regions (Shine et al 2014, Handojoseno et al 2015. Interestingly, previous research has also demonstrated that people with PD show abnormalities in beta oscillatory activity in the basal ganglia (subthalamic nucleus, STN) and cerebral cortex at rest as well as during movement (Brown 2007, Jenkinson & Brown 2011, van Wijk et al 2012, Oswal et al 2013, Wilson 2015.…”

Section: Introductionmentioning

confidence: 95%

Corticomuscular control of walking in older people and people with Parkinson’s disease

Roeder

Boonstra

Kerr

2019

Preprint

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Changes in human gait that result from ageing or neurodegenerative diseases are multifactorial. Here we assess the effects of age and Parkinson’s disease (PD) on corticospinal control in electrophysiological activity recorded during treadmill and overground walking. Electroencephalography (EEG) from 10 electrodes and electromyography (EMG) from two leg muscles were acquired from 22 healthy young, 24 healthy older and 20 adults with PD. Event-related power, corticomuscular coherence (CMC) and inter-trial coherence were assessed for EEG from bilateral sensorimotor cortices and EMG from tibialis anterior muscles during the double support phase of the gait cycle. CMC and EMG power in the low beta band (13-21 Hz) was significantly decreased in older and PD participants compared to young people, but there was no difference between older and PD groups. Older and PD participants spent shorter time in the swing phase than young individuals. These findings indicate age-related changes in the temporal coordination of gait. The decrease in beta CMC suggests reduced cortical input to spinal motor neurons in older people during the double support phase. We also observed multiple changes in electrophysiological measures at high beta and low gamma frequencies during treadmill compared to overground walking, indicating task-dependent differences in corticospinal locomotor control.

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“…This is in alignment with recent behavioural data showing impaired conflict resolution in FOG+ patients (Matar et al, ; Vandenbossche et al, ). Additionally, a recent electroencephalography (EEG) study in patients with FOG was able to associate transitions from walking to freezing with increases in the theta frequency band (Handojoseno et al, ; Shine et al, ). Increased power within this frequency band has been linked behaviourally with a delayed reaction time in high conflict scenarios and corresponds to activation with the STN (Cavanagh & Frank, ).…”

Section: Discussionmentioning

confidence: 99%

Identifying the neural correlates of doorway freezing in Parkinson's disease

Matar

Shine

Gilat

et al. 2019

Human Brain Mapping

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Freezing of gait (FOG) in Parkinson's disease (PD) is frequently triggered upon passing through narrow spaces such as doorways. However, despite being common the neural mechanisms underlying this phenomenon are poorly understood. In our study, 19 patients who routinely experience FOG performed a previously validated virtual reality (VR) gait paradigm where they used foot‐pedals to navigate a series of doorways. Patients underwent testing randomised between both their “ON” and “OFF” medication states. Task performance in conjunction with blood oxygenation level dependent (BOLD) signal changes between “ON” and “OFF” states were compared within each patient. Specifically, as they passed through a doorway in the VR environment patients demonstrated significantly longer “footstep” latencies in the OFF state compared to the ON state. As seen clinically in FOG this locomotive delay was primarily triggered by narrow doorways rather than wide doorways. Functional magnetic resonance imaging revealed that footstep prolongation on passing through doorways was associated with selective hypoactivation in the presupplementary motor area (pSMA) bilaterally. Task‐based functional connectivity analyses revealed that increased latency in response to doorways was inversely correlated with the degree of functional connectivity between the pSMA and the subthalamic nucleus (STN) across both hemispheres. Furthermore, increased frequency of prolonged footstep latency was associated with increased connectivity between the bilateral STN. These findings suggest that the effect of environmental cues on triggering FOG reflects a degree of impaired processing within the pSMA and disrupted signalling between the pSMA and STN, thus implicating the “hyperdirect” pathway in the generation of this phenomenon.

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An EEG study of turning freeze in Parkinson's disease patients: The alteration of brain dynamic on the motor and visual cortex

Cited by 28 publications

References 16 publications

Corticomuscular control of walking in older people and people with Parkinson’s disease

Corticomuscular control of walking in older people and people with Parkinson’s disease

Corticomuscular control of walking in older people and people with Parkinson’s disease

Identifying the neural correlates of doorway freezing in Parkinson's disease

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