An Effect of Adrenalectomy and Cortisone on Tissue Permeability in vitro

Changes in enzymes of the uterus of the ovariectomized rat after treatment with oestradiol

“…These various experimental results, although performed in different laboratories with all the variability of procedure, animals and even dosage, do seem to fall into a logical sequence. The early changes suggest an effect of the oestrogens and other steroids on permeability, as has been noted before (Kalman & Lowenstein, 1958;Elliott & Yrarrazaval, 1952). There is evidence that the primary effect of oestradiol is on the capillaries, causing permeability to protein but not to red cells (Kalman, 1958;Zierler, 1958).…”

Use of glucocorticoids in the palliative treatment of metastatic brain tumors

“…* All of the patients included had histologically verified malignancies as well as clearcut and progressive neurologic manifestations which could only be explained by the development of intra-cranial metastases. Prednisone, prednisolone, methylprednisolone, dexamethasone or intravenous hydrocortisone were used for a minimum of 6 days. Most patients initially received the equivalent of 60 to 120 mg./day of prednisone; however, u p to 200 mg./day was used.…”