An effective antidote for paraquat poisonings: The treatment with lysine acetylsalicylate

Dinis-Oliveira, Ricardo Jorge; Pontes, Helena; Bastos, Maria de Lourdes; Remião, Fernando; Duarte, José Alberto; Carvalho, Félix

doi:10.1016/j.tox.2008.10.015

Cited by 49 publications

(45 citation statements)

References 24 publications

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“…This results in a 6-10-fold increase in the lung PQ levels compared with plasma levels. Based on its induction of redox cycling, PQ in the lung results in oxidative stress-associated cell death and lung injury (14,15). Sirtuins are a unique class of type III histone deacetylases with seven isoforms, SIRT1-7 (16).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways

Zhao

Chen

et al. 2015

Molecular Medicine Reports

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Abstract. Sirtuin 1 (SIRT1) acts via the deacetylation of a number of crucial transcription factors and has been implicated in various biological processes, including oxidative stress. Previous studies have indicated that nuclear factor, erythroid 2-like 2 (NRF2) is an effective target of antioxidant therapy for paraquat (PQ) poisoning. However, the association between SIRT1 and NRF2 and their effects in PQ-induced oxidative stress remains to be elucidated. The current study demonstrated that PQ exposure upregulated the expression of SIRT1 and NRF2 following 6-and 24-h exposure in the lungs of mice. However, long-term exposure to PQ significantly decreased the expression of SIRT1 and NRF2. Resveratrol is a SIRT1 activator, and strongly enhanced SIRT1 expression and attenuated the lung injury resulting from PQ exposure in the current study. Additionally, treatment with resveratrol upregulated the expression of NRF2 and glutathione, increased the activity of heme oxygenase-1, superoxide dismutase and catalase, but depleted the expression of malondialdehyde. The present results demonstrated that resveratrol reduced PQ-induced oxidative stress and lung injury, potentially through the positive feedback signaling loop between SIRT1 and NRF2.

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Section: Discussionmentioning

confidence: 99%

Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways

Zhao

Chen

et al. 2015

Molecular Medicine Reports

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“…and lysine ASA (100 mg/Kg i.p.) led to full survival of paraquat intoxicated rats [145][146][147] [148]. Although several other mechanisms were also proposed for the protective effect of salicylates, the dose range used inhibited PQ-induced NF-kB activation [146].…”

Section: Inhibition Of Nf-b Ap-1 and Protein Kinasesmentioning

confidence: 99%

Antioxidant Properties and Associated Mechanisms of Salicylates

Baltazar¹,

Dinis-Oliveira

Duarte³

et al. 2011

CMC

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The pharmacological action of salicylates has been historically related to their ability to inhibit cyclooxygenases, thereby blocking the synthesis of prostaglandins and thromboxane A2. On the other hand, several studies have suggested that salicylates have a multitude of cyclooxygenase-independent actions specially related with their antioxidant properties, which might contribute to the overall salutary effects of these compounds. Although salicylates are well-known antioxidants through their ability to scavenge hydroxyl radical, their antioxidant mechanisms of action have not been fully compiled and characterized. In this context, several mechanisms of action have been suggested, namely i) scavenging of hydroxyl radical and chelation of transition metals; ii) upregulation of nitric oxide; iii) increased synthesis of lipoxins; iv) inhibition of neutrophil oxidative burst; v) inhibition of NF-κB and AP-1 protein kinases; and vii) inhibiton of lectin-like oxidized LDL receptor-1. The newly discovered acetyl salicylic acid-triggered lipoxins probably play a key role in the maintenance of the oxidative stress balance. Furthermore, salicylates have shown to protect low-density lipoprotein from oxidation and elicit an inhibitory effect on the expression of lectin-like receptors on endothelial cells. This review aims to provide an overview of the various proposed antioxidant mechanisms of salicylates.

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“…Clinical studies have shown the anti-aging benefits of sodium salicylate in human skin [43]. Salicylate and its derivatives [44,45] have been regarded as one of the most interesting pharmacologic compounds with many undisclosed therapeutic properties. Sodium salicylate (NaSAL) could also represent a powerful antidote to be used against paraquat (PQ) poisonings.…”

Section: Introductionmentioning

confidence: 99%

Investigating the effect of salicylate salt in enhancing the corrosion resistance of AZ91 magnesium alloy for biomedical applications

et al. 2016

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Abstract:The pretreatment process plays a vital role in the development of a robust protective layer on magnesium alloys. This work presents a novel insight into the pretreatment of magnesium alloy AZ91 in alkaline silicate solution by anodic oxidation in the presence of C 7 H 5 NaO 3 (sodium salicylate) to enhance surface resistance and introduce a passive biolayer. The electrochemical corrosion behavior of protective layers prepared at different voltages was evaluated by electrochemical impedance spectroscopy (EIS) in SBF solution. The Nyquist impedance plots for anodized films, which consist of a mixture of magnesium silicate and salicylate, indicate a significant corrosion protection ability of the layers formed under optimized conditions; an increase of the real impedance from the value of ~2 kΩ.cm 2 for the bare alloy surface to about 10-12 kΩ.cm 2 for the anodized film can be observed. The results indicate that surface modification by anodizing in silicate electrolyte in the presence of sodium salicylate is an alternative pretreatment to improve the corrosion resistance of AZ91.

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An effective antidote for paraquat poisonings: The treatment with lysine acetylsalicylate

Cited by 49 publications

References 24 publications

Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways

Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways

Antioxidant Properties and Associated Mechanisms of Salicylates

Investigating the effect of salicylate salt in enhancing the corrosion resistance of AZ91 magnesium alloy for biomedical applications

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