An effective antioxidant drug on prevention of the necrosis of zone of stasis: N-acetylcysteine

Deniz, Murat; Borman, Hüseyin; Seyhan, Tamer; Haberal, Mehmet

doi:10.1016/j.burns.2012.06.015

Cited by 51 publications

(52 citation statements)

References 26 publications

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“…19 Murat et al described NAC as a potent antioxidant since it prevents the necrosis of zone of stasis. 20 Demir et al reported that the healing of the wounds in irradiated rats was improved by intraperitoneal or oral administration of NAC. 21 MinLing Tsai et al reported that the topical administration of 3% NAC was significantly effective on the cell proliferation, migration, scratch wound healing, and collagenous expression of MMP-1 via the PKC/ Stat3 signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Topical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study

Oğuz

Uslukaya

Alabalık

et al. 2015

International Surgery

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In this study, we aimed to compare the effects of dexpanthenol and N-acetylcysteine on wound healing. The wound healing process is a multifaceted sequence of activities associated with tissue restoration process. A number of investigations and clinical studies have been performed to determine new approaches for the improvement of wound healing. A total of 30 rats were divided into 3 equal groups. A linear 2-cm incision was made in the rats' skin. No treatment was administered in the first (control) group. Dexpanthenol cream was administered to the rats in the second group and 3% Nacetylcysteine cream was administered to the rats in the third group. The wound areas of all of the rats were measured on certain days. On the 21st day, all wounds were excised and histologically evaluated. The epithelialization and granulation rates between the groups were revealed to be similar in microscopic evaluations. Although the fibrosis was remarkable in the control group as compared with the other groups, it was similar in Nacetylcysteine and dexpanthenol groups. Angiogenesis rate was remarkable in the Nacetylcysteine group compared with the others. In multiple-comparison analysis, Dexpanthenol and N-acetylcysteine groups had similar results in terms of wound healing rates (P , 0.05), which were both higher than in the control group (P . 0.05). The efficacy of N-acetylcysteine in wound healing is comparable to dexpanthenol, and both substances can be used to improve wound healing.

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Section: Discussionmentioning

confidence: 99%

Topical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study

Oğuz

Uslukaya

Alabalık

et al. 2015

International Surgery

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“…RJ has also been demonstrated to possess many pharmacological activities in experimental animals, including antitumor [19], antioxidant [20, 21], anti-inflammatory [22], antibacterial [23], antiallergic [24], antiaging [25], and antihypertensive properties [26]. Recently, many authors have reported that the antioxidant effect is important for wound healing [27–29]. In this respect, RJ is an ideal agent.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Topical Application of Royal Jelly on Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: A Preliminary Study

Yamauchi

Kogashiwa

Moro

et al. 2014

International Journal of Otolaryngology

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Purpose. One of the common side effects experienced by head and neck cancer patients on chemoradiotherapy is mucositis. Severe mucositis may be controllable by limiting cancer therapy, but it has resulted in decreasing the completion rate of chemoradiotherapy. The efficacy of royal jelly (RJ) as prophylaxis against chemoradiotherapy-induced mucositis was evaluated through clinical scoring of oral and pharyngeal mucositis. Methods. In this randomized, single-blind (physician-blind), clinical trial, 13 patients with head and neck cancer requiring chemoradiation were randomly assigned to two groups. Seven patients assigned to the study group received RJ, and 6 patients were assigned to the control group. RJ group patients took RJ three times per day during treatment. The patients in both groups were evaluated twice a week for the development of mucositis using Common Terminology Criteria for Adverse Events version 3.0. Results. A significant reduction in mucositis was seen among RJ-treated patients compared with controls (P < 0.001). Conclusion. This study demonstrated that prophylactic use of RJ was effective in reducing mucositis induced by chemoradiotherapy in head and neck cancer patients. However, further studies are needed because of the small sample size and the absence of double blinding.

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“…Recently, many investigators have reported that the antioxidant effect is an important ideal agent for healing of the wounds [18][19][20] . Inoue et al [9] reported the ameliorative role of dietary RJ on DNA oxidative damage in mice.…”

Section: Introductionmentioning

confidence: 99%

The effect of ethanol on rat tongue and the possible protective role of royal jelly: Light and scanning electron microscopic study

Altayeb

Salem

2017

Egyptian Journal of Histology

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Background: Ethanol is the most commonly used and abused xenobiotic in the world. Royal jelly (RJ) has been considered as an antioxidant that protects against different agents. Aim of the work: This study aimed to investigate the effect of ethanol on the rat tongue and the possible protective role of royal jelly. Material and methods: Twenty five adult male rats were used in this study and were divided into 4 groups. Group I: 10 rats were divided equally into negative and positive controls. Group II: 5 rats received RJ at a dose of 100 mg/kg body weight by gastric tube daily for 30 days. Group III: 5 rats received ethanol at a dose of 10 ml/kg body weight from 30% v/v ethanol solution in distilled water by a gastric tube daily for 30 days. Group IV: 5 rats received both RJ and ethanol as the same previous doses by gastric tube for 30 days. Tongue sections were histologically prepared and examined. Results:The results revealed that group II was nearly as group I. Group III revealed by LM dorsal surface of the tongue was covered by irregularly arranged, short and long lingual papillae. Some papillae were thin, with blunted tips and others were completely absent. The epithelial lining of the ventral surface also showed an apparent reduction in thickness. The keratin layer of the ventral surfaces of the tongue appeared in some regions discontinuous and detached. Some skeletal muscle fibers revealed separations and vacuolations. Scanning electron microscope (SEM) examination revealed a noticeable atrophy of lingual papillae from being short to being absent in focal areas. They were irregularly arranged in different directions. Group IV revealed amelioration of these changes. Conclusion: Ethanol has damaging effects on the lingual papillae and muscles and royal jelly has a protective role for these effects.

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An effective antioxidant drug on prevention of the necrosis of zone of stasis: N-acetylcysteine

Cited by 51 publications

References 26 publications

Topical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study

Topical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study

The Effect of Topical Application of Royal Jelly on Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: A Preliminary Study

The effect of ethanol on rat tongue and the possible protective role of royal jelly: Light and scanning electron microscopic study

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