An effective drug-disease associations prediction model based on graphic representation learning over multi-biomolecular network

Abstract

Background Drug-disease associations (DDAs) can provide important information for exploring the potential efficacy of drugs. However, up to now, there are still few DDAs verified by experiments. Previous evidence indicates that the combination of information would be conducive to the discovery of new DDAs. How to integrate different biological data sources and identify the most effective drugs for a certain disease based on drug-disease coupled mechanisms is still a challenging problem. Results In this paper, we proposed a novel computation model for DDA predictions based on graph representation learning over multi-biomolecular network (GRLMN). More specifically, we firstly constructed a large-scale molecular association network (MAN) by integrating the associations among drugs, diseases, proteins, miRNAs, and lncRNAs. Then, a graph embedding model was used to learn vector representations for all drugs and diseases in MAN. Finally, the combined features were fed to a random forest (RF) model to predict new DDAs. The proposed model was evaluated on the SCMFDD-S data set using five-fold cross-validation. Experiment results showed that GRLMN model was very accurate with the area under the ROC curve (AUC) of 87.9%, which outperformed all previous works in terms of both accuracy and AUC in benchmark dataset. To further verify the high performance of GRLMN, we carried out two case studies for two common diseases. As a result, in the ranking of drugs that were predicted to be related to certain diseases (such as kidney disease and fever), 15 of the top 20 drugs have been experimentally confirmed. Conclusions The experimental results show that our model has good performance in the prediction of DDA. GRLMN is an effective prioritization tool for screening the reliable DDAs for follow-up studies concerning their participation in drug reposition.

Protein-compound Interaction Prediction Using Microbial Chemical Communication Network

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Integrated Analysis of Tissue-Specific Gene Expression in Diabetes by Tensor Decomposition Can Identify Possible Associated Diseases

“…Therefore, we were not surprised that the integrated analysis using the proposed method was able to identify disease associations. To our knowledge, few studies have attempted to predict the association between diseases using gene expression, although many studies have focused on the associations between genes and disease [ 20 , 21 , 22 ] and between drugs and disease association [ 23 , 24 , 25 ]. Our proposed strategy would be useful for such studies.…”

Integrated Analysis of Tissue-specific Gene Expression in Diabetes by Tensor Decomposition Can Identify Possible Associated Diseases

“…Therefore, we were not surprised that the integrated analysis using the proposed method was able to identify disease associations. To our knowledge, few studies have attempted to predict the association between diseases using gene expression, although many studies have focused on the associations between genes and disease [21][22][23] and between drugs and disease association [24][25][26]. Our proposed strategy would be useful for such studies.…”