Publisher: Elsevier © 2017 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. This document is the author's post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it. Abstract-Cylindrical Algebraic Decomposition (CAD) is a key tool in computational algebraic geometry, particularly for quantifier elimination over real-closed fields. However, it can be expensive, with worst case complexity doubly exponential in the size of the input. Hence it is important to formulate the problem in the best manner for the CAD algorithm. One possibility is to precondition the input polynomials using Groebner Basis (GB) theory. Previous experiments have shown that while this can often be very beneficial to the CAD algorithm, for some problems it can significantly worsen the CAD performance.In the present paper we investigate whether machine learning, specifically a support vector machine (SVM), may be used to identify those CAD problems which benefit from GB preconditioning. We run experiments with over 1000 problems (many times larger than previous studies) and find that the machine learned choice does better than the human-made heuristic.