An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol

Abstract

The synthesis 2-tert-butyl-4-methylphenol is of great significance because of its widely application in industry, and the development of highly efficient catalyst is necessary to the alkylation of p-cresol and tert-butyl alcohol. Here, an efficient and mild method was established, caprolactam was chosen as hydrogen-bonding acceptor, p-toluenesulfonic acid was employed as hydrogen-bonding donor, and deep eutectic solvent (DES) was prepared to catalyze the alkylation reaction. The structure of the DES catalyst was characterized by 1H NMR spectra, thermogravimetric analysis and fourier transform infrared spectra (FT-IR). In addition, response surface design based on Box-Behnken method was employed to optimize the alkylation reaction process parameters, the study of reaction kinetics was also carried out subsequently. The recycle performance of the catalyst was evaluated by recovery experiments, and a good result was obtained. Comparing with the literature reported, we here provide a mild method to the synthesis of 2-tert-butyl-4-methylphenol.

Transcranial direct current stimulation of the prefrontal and visual cortices diversely affects early and late perceptual learning

“…On the other hand, to achieve satisfactory improvement in visual function, it is often necessary to undergo an extensive period of training (Herpich et al, 2019), which limits the application of VPL to some extent. Fortunately, research has demonstrated that NIBS not only directly improves visual perception (Battaglini et al, 2017;Reinhart et al, 2016) but also enhances VPL when combined with behavioral training (He et al, 2021;Wu et al, 2022).…”